91 publication(s) trouvée(s)
Article scientifique
Coenzyme Q10 protects against atorvastatin-induced hepatotoxicity via attenuation of oxidative stress and functional modulation of CYP3A1
BACKGROUND: Atorvastatin (ATO) is a widely prescribed lipid-lowering drug, but its use can be limited by hepatotoxicity, potentially linked to …
Article scientifique
The correlation between Interleukin 1 β (IL-1β) as an inflammatory marker and Malondialdehyde (MDA) as a lipid peroxidation marker and the development of cardiac and pancreatic complications in humans suspected to scorpion poisoning
BACKGROUND: Scorpion envenomation is a common health problem all over the world. Recent experimental studies on animals were held to …
Article scientifique
Therapeutic potential of zinc oxide/berberine nanoparticles in mitigating acute respiratory distress syndrome: in vivo and in silico approaches
BACKGROUND: Inflammation and oxidative stress strongly contribute to the pathophysiology of acute respiratory distress syndrome (ARDS), which is a life-threatening …
Article scientifique
Biochemical, histopathological, and immunohistochemical study on the ameliorative effect of crocin against lipopolysaccharide‑induced hippocampal toxicity in male albino rats
BACKGROUND: Lipopolysaccharide (LPS)-induced neuroinflammation is widely used as an animal model for studying the mechanisms of neuroinflammation. Crocin, an active …
Article scientifique
Renoprotective impact of tiron against diclofenac-induced nephrotoxicity: targeting TLR4/NF-κB/NLRP3/Caspase-1/IL1-β pathway
Nephrotoxicity is a documented side effect of non-steroidal anti-inflammatory drugs (NSAIDs) like diclofenac (Diclo). Thus, this study was executed to …
Article scientifique
Effects of chronic nicotine administration on behavioral parameters and Na⁺/K⁺-ATPase mRNA expression in the brains of male Swiss Albino mice exposed to chronic stress during adolescence
BACKGROUND: Stress during adolescence leads to the development of major stress-related diseases. The use of psychoactive substances and most psychiatric …
Article scientifique
Obeticholic acid prevents cyclophosphamide-induced placental injury via SIRT1 and TLR4/NF-κB pathways
BACKGROUND: The aim of the current study is to identify the possible protective effect of obeticholic acid (OCA) on placental …
Article scientifique
Nano-encapsulated ferulic acid in sesame protein isolate alleviates acrylamide-induced liver toxicity and genotoxicity in rats via oxidative stress and DNA damage modulation
BACKGROUND: Acrylamide (ACR) induces hepatotoxicity and genotoxicity through oxidative stress and inflammatory processes. AIMS: This study explores the potential of …
Article scientifique
Effect of adding fenofibrate versus curcumin to glimepiride in patients with type 2 diabetes: a randomized controlled trial
BACKGROUND: Type 2 diabetes is a recognized risk factor for the development of cardiovascular disease. Fenofibrate and curcumin were found …
Article scientifique
Co-treatment of β-carotene with acetamiprid provides protection against acetamiprid induced hepatic and renal toxicity via modulation of the antioxidant system
BACKGROUND: Acetamiprid (ACMP), one of the most widely used and effective insecticides globally, can pose potential toxicity to mammals. β-carotene …
Article scientifique
Predictive role of cystatin C and increased proteinuria in early assessment of acute renal toxicity in patient poisoned by nephrotoxic drugs and poisons
BACKGROUND: Acute kidney injury (AKI) is prevalent in critical care, often due to nephrotoxic drug exposure, which accounts for significant …
Article scientifique
Hepatoprotective activity of bio-fabricated carbon quantum dots-decorated zinc oxide against carbon tetrachloride-induced liver injury in male rats
BACKGROUND: Cirrhosis is considered as a severe liver disease that causes partial liver damage as well as total liver destruction; …
Article scientifique
Trimetazidine effect on kidney function in patients undergoing coronary procedures
BACKGROUND: CIN (Contrast-induced Nephropathy) was studied after Percutaneous Coronary Intervention (PCI) or Coronary Angiography (CA). Trimetazidine (TMZ) has been investigated …
Article scientifique
Can vildagliptin protect against radiation-induced premature ovarian failure? Insights into the AMPK and AKT signaling pathways
BACKGROUND: Among the detrimental side effects caused by radiotherapy in young females is the ovarian damage, eventually causing premature ovarian …
Article scientifique
Quercetin-mediated restoration of high-fat diet-induced male reproductive dysfunction through modifying spermatogenesis and unraveling 3β-HSD, 17β-HSD, and StAR pathways
PURPOSE: We explored the astounding potential of quercetin (QRT) to counteract the determinantal impacts of a high-fat diet (HFD) on …
Article scientifique
A comparative study of using scorpion antivenom versus scorpion antivenom and prazosin drug for scorpion stings management in Sohag University Hospitals
BACKGROUND: Scorpion envenomation is a worldwide problem, especially in tropical and subtropical areas like Egypt. Scorpion envenomation is responsible for …
Article scientifique
Boswellic acid synergizes with low-dose ionizing radiation to mitigate thioacetamide-induced hepatic encephalopathy in rats
Hepatic encephalopathy (HE) is a syndrome that arises from acute or chronic liver failure. This study was devised to assess …
Article scientifique
The therapeutic role of naringenin nanoparticles on hepatocellular carcinoma
BACKGROUND: Naringenin, a flavonoid compound found in citrus fruits, possesses valuable anticancer properties. However, its potential application in cancer treatment …
Article scientifique
The effect of vildagliptin versus metformin on hepatic steatosis in type 2 diabetic patients: a randomized controlled trial
BACKGROUND: The risk of hepatic steatosis (HS) is elevated in patients with type 2 diabetes mellitus (T2D). Antidiabetic medications may …
Article scientifique
L-carnitine attenuates autophagic flux, apoptosis, and necroptosis in rats with dexamethasone-induced non-alcoholic steatohepatitis
BACKGROUND: UpToDate, no drugs have been approved to treat nonalcoholic steatohepatitis, the advanced stage of the most prevalent liver disease, …
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