7 publication(s) trouvée(s)
Article scientifique
Genetics of cerebral malaria: pathogenesis, biomarkers and emerging therapeutic interventions
BACKGROUND: Cerebral malaria (CM) is a preeminent cause of severe disease and premature deaths in Sub-Saharan Africa, where an estimated …
Article scientifique
Intracellular proteome compartmentalization: a biotin ligase-based proximity labeling approach
Specialized biological processes occur in different regions and organelles of the cell. Additionally, the function of proteins correlate greatly with …
Article scientifique
Autophagy in the control and pathogenesis of parasitic infections
BACKGROUND: Autophagy has a crucial role in the defense against parasites. The interplay existing between host autophagy and parasites has …
Article scientifique
NICD-mediated notch transduction regulates the different fate of chicken primordial germ cells and spermatogonial stem cells
Notch signaling is mainly regulated by Notch1 during development of chicken germ stem cells; however, the molecular mechanisms that contribute …
Article scientifique
Tumor cells versus host immune cells: whose PD-L1 contributes to PD-1/PD-L1 blockade mediated cancer immunotherapy?
Antibody blockade of the PD-1/PD-L1 pathway has elicited durable antitumor responses in the therapy of a broad spectrum of cancers. …
Article scientifique
Anti-CTLA-4 antibodies in cancer immunotherapy: selective depletion of intratumoral regulatory T cells or checkpoint blockade?
Antibodies to human CTLA-4 have been shown to induce long-lasting protection against melanoma. It is assumed that these antibodies cause …
Article scientifique
Syncytium calcium signaling and macrophage function in the heart
Macrophages are traditionally viewed as a key component of the immunity defense system. Recent studies have identified resident macrophages in …