35 publication(s) trouvée(s)
Article scientifique
CD90 determined two subpopulations of glioma-associated mesenchymal stem cells with different roles in tumour progression
Abstract Human glioma-associated mesenchymal stem cells (gbMSCs) are the stromal cell components that contribute to the tumourigenesis of malignant gliomas. …
Article scientifique
p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis
The tumor suppressor p53 has critical roles in regulating lipid metabolism, but whether and how p53 regulates cardiolipin (CL) de …
Article scientifique
MALAT1–miR663a negative feedback loop in colon cancer cell functions through direct miRNA–lncRNA binding
The lncRNA MALAT1 has multiple biological functions, including influencing RNA processing, miRNA sponging, and cancer development. It is acknowledged that …
Article scientifique
A novel oral camptothecin analog, gimatecan, exhibits superior antitumor efficacy than irinotecan toward esophageal squamous cell carcinoma in vitro and in vivo
Abstract Esophageal squamous cell carcinoma (ESCC) is a frequently diagnosed and deadly malignancy with few standard therapeutic options. Camptothecins are …
Article scientifique
PFKFB3 blockade inhibits hepatocellular carcinoma growth by impairing DNA repair through AKT
Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a key molecule of glucose metabolism in cytoplasm, has been found in various tumors. Emerging …
Article scientifique
Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2–MRN–ATM axes
Abstract RPS27L (ribosomal protein S27-like) is an evolutionarily conserved ribosomal protein and a direct p53 target. We recently reported that …
Article scientifique
miR-27b-3p inhibits proliferation and potentially reverses multi-chemoresistance by targeting CBLB/GRB2 in breast cancer cells
Drug resistance remains a major problem in the treatment of conventional chemotherapeutic agents in breast cancers. Owing to heterogeneity and …
Article scientifique
Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway
Abstract Paclitaxel (PTX) is widely used in the front-line chemotherapy for gastric cancer (GC), but resistance limits its use. Due …
Article scientifique
iASPP facilitates tumor growth by promoting mTOR-dependent autophagy in human non-small-cell lung cancer
Autophagy serves a critical function in the pathogenesis, response to therapy and clinical outcome in cancers. Although a recent report …
Article scientifique
A novel acridine derivative, LS-1-10 inhibits autophagic degradation and triggers apoptosis in colon cancer cells
Autophagy promotes cancer cell survival and drug resistance by degrading harmful cellular components and maintaining cellular energy levels. Disruption of …
Article scientifique
Retinoic acid-induced upregulation of miR-219 promotes the differentiation of embryonic stem cells into neural cells
MicroRNAs (miRNAs) regulate critical cell processes, such as apoptosis, proliferation, and development. However, the role of miRNAs in embryonic stem …
Article scientifique
Calcium-binding protein S100A14 induces differentiation and suppresses metastasis in gastric cancer
Abstract S100A14 is a calcium-binding protein involved in cell proliferation and differentiation as well as the metastasis of human tumors. …
Article scientifique
MicroRNA-29a induces loss of 5-hydroxymethylcytosine and promotes metastasis of hepatocellular carcinoma through a TET–SOCS1–MMP9 signaling axis
Ten eleven translocation (TET) enzymes convert 5-methylcytosine (5-mC) to 5-hydroxy-methylcytosine (5-hmC) and have crucial roles in biological and pathological processes …
Article scientifique
Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells
Abstract Atopic dermatitis (AD) is a chronic Th2 type inflammatory skin disorder. Here we report that MyD88 signaling is crucial …
Article scientifique
Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway
The ubiquitin-proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to …
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