16 publication(s) trouvée(s)
Article scientifique
Methylation changes and INS-IGF2 expression predict progression in early-stage Wilms tumor
Abstract Wilms tumor, the most common pediatric kidney cancer, accounts for 5% of childhood cancers and is classified by stage …
Article scientifique
Discovery and technical validation of high-performance methylated DNA markers for the detection of cervical lesions at risk of malignant progression in low- and middle-income countries
BACKGROUND: Cervical cancer remains a leading cause of death, particularly in developing countries. WHO screening guidelines recommend human papilloma virus …
Article scientifique
Epigenetic aging in older people living with HIV in Eswatini: a pilot study of HIV and lifestyle factors and epigenetic aging
Abstract Background People living with HIV (PLHIV) on effective antiretroviral therapy are living near-normal lives. Although they are less susceptible …
Article scientifique
Tazemetostat decreases β-catenin and CD13 protein expression in HEPG-2 and Hepatitis B virus-transfected HEPG-2 with decreased cell viability
Hepatocellular carcinoma (HCC) is one of the global health concerns. Hepatitis B virus (HBV) is one of the major causes …
Article scientifique
DNA methylation as a potential mediator of the association between indoor air pollution and neurodevelopmental delay in a South African birth cohort
Abstract Background Exposure to indoor air pollution during pregnancy has been linked to neurodevelopmental delay in toddlers. Epigenetic modification, particularly …
Article scientifique
DNA methylation patterns associated with konzo in Sub-Saharan Africa
Konzo, a disease characterized by sudden, irreversible spastic paraparesis, affecting up to 10% of the population in some regions of …
Article scientifique
Epigenetic tumor heterogeneity in the era of single-cell profiling with nanopore sequencing
Nanopore sequencing has brought the technology to the next generation in the science of sequencing. This is achieved through research …
Article scientifique
DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study
BACKGROUND: The prevalence of cardiometabolic disease (CMD) is rising globally, with environmentally induced epigenetic changes suggested to play a role. …
Article scientifique
DNA methylation of FKBP5 in South African women: associations with obesity and insulin resistance
BACKGROUND: Disruption of the hypothalamic-pituitary-adrenal (HPA) axis, a neuroendocrine system associated with the stress response, has been hypothesized to contribute …
Article scientifique
Replication and expansion of epigenome-wide association literature in a black South African population
BACKGROUND: DNA methylation is associated with non-communicable diseases (NCDs) and related traits. Methylation data on continental African ancestries are currently …
Article scientifique
The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness
BACKGROUND: Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-methylation …
Article scientifique
Assessment of new HDAC inhibitors for immunotherapy of malignant pleural mesothelioma
Background: Malignant pleural mesothelioma (MPM) is a very rare and highly aggressive cancer of the pleura associated in most cases …
Article scientifique
Identification of a key role of widespread epigenetic drift in Barrett’s esophagus and esophageal adenocarcinoma
BACKGROUND: Recent studies have identified age-related changes in DNA methylation patterns in normal and cancer tissues in a process that …
Article scientifique
Transcriptomics and methylomics in chronic periodontitis with tobacco use: a pilot study
BACKGROUND: Accumulating evidence suggests that tobacco smoking affects the susceptibility to and severity of chronic periodontitis. Epigenetics may explain the …
Article scientifique
Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs
BACKGROUND: Cord blood is a commonly used tissue in environmental, genetic, and epigenetic population studies due to its ready availability …
Article scientifique
The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases
The CpG island methylator phenotype (CIMP) in stage III colon cancer (CRC) has been associated with improved survival after treatment …