56 publication(s) trouvée(s)
Article scientifique
Multidimensional analyses reveal modulation of adaptive and innate immune subsets by tuberculosis vaccines
Abstract We characterize the breadth, function and phenotype of innate and adaptive cellular responses in a prevention ofMycobacterium tuberculosisinfection trial. …
Article scientifique
Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism
Abstract Hyper-virulent Streptococcus pneumoniae serotype 1 strains are endemic in Sub-Saharan Africa and frequently cause lethal meningitis outbreaks. It remains …
Article scientifique
Artificial eyespots on cattle reduce predation by large carnivores
Eyespots evolved independently in many taxa as anti-predator signals. There remains debate regarding whether eyespots function as diversion targets, predator …
Article scientifique
Genome-wide association study of Buruli ulcer in rural Benin highlights role of two LncRNAs and the autophagy pathway
Abstract Buruli ulcer, caused by Mycobacterium ulcerans and characterized by devastating necrotizing skin lesions, is the third mycobacterial disease worldwide. …
Article scientifique
Leveraging genomic diversity to promote human and animal health
Genomic diversity is a driving force influencing human and animal health, and susceptibility to disease. During the Keystone Symposium on …
Article scientifique
Transcontinental dispersal of Anopheles gambiae occurred from West African origin via serial founder events
Abstract The mosquito Anopheles gambiae s.s. is distributed across most of sub-Saharan Africa and is of major scientific and public …
Article scientifique
The podocin V260E mutation predicts steroid resistant nephrotic syndrome in black South African children with focal segmental glomerulosclerosis
Abstract In black African children with focal segmental glomerulosclerosis (FSGS) there are high rates of steroid resistance. The aim was …
Article scientifique
Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations
Abstract Red blood cells (RBCs) play a critical role in oxygen transport, and are the focus of important diseases including …
Article scientifique
Cryo-EM and directed evolution reveal how Arabidopsis nitrilase specificity is influenced by its quaternary structure
Abstract Nitrilases are helical enzymes that convert nitriles to acids and/or amides. All plants have a nitrilase 4 homolog specific …
Article scientifique
Changes in rainfall distribution promote woody foliage production in the Sahel
Abstract Dryland ecosystems comprise a balance between woody and herbaceous vegetation. Climate change impacts rainfall timing, which may alter the …
Article scientifique
Tackling the re-emergence of wheat stem rust in Western Europe
Abstract In our recent Communications Biology article, we reported the first occurrence of wheat stem rust in the UK in …
Article scientifique
Substrate specificity of plant nitrilase complexes is affected by their helical twist
Abstract Nitrilases are oligomeric, helix-forming enzymes from plants, fungi and bacteria that are involved in the metabolism of various natural …
Article scientifique
Evaluation of a recombination-resistant coronavirus as a broadly applicable, rapidly implementable vaccine platform
Emerging and re-emerging zoonotic viral diseases are major threats to global health, economic stability, and national security. Vaccines are key …
Article scientifique
The lantibiotic nukacin ISK-1 exists in an equilibrium between active and inactive lipid-II binding states
The lantibiotic nukacin ISK-1 exerts antimicrobial activity through binding to lipid II. Here, we perform NMR analyses of the structure …
Article scientifique
High-resolution small RNA structures from exact nuclear Overhauser enhancement measurements without additional restraints
RNA not only translates the genetic code into proteins, but also carries out important cellular functions. Understanding such functions requires …
Article scientifique
Potential for re-emergence of wheat stem rust in the United Kingdom
Abstract Wheat stem rust, a devastating disease of wheat and barley caused by the fungal pathogen Puccinia graminis f. sp. …
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