56 publication(s) trouvée(s)
Article scientifique
A genome-wide association study identifies distinct variants associated with pulmonary function among European and African ancestries from the UK Biobank
Pulmonary function is an indicator of well-being, and pulmonary pathologies are the third major cause of death worldwide. We analysed …
Article scientifique
Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10
Mycobacterium tuberculosis (Mtb) is one of the most successful human pathogens. Several cytokines are known to increase virulence of bacterial …
Article scientifique
Ovine HOXB13: expanding the gene repertoire of sheep tail patterning and implications in genetic improvement
Understanding the genetic basis of sheep tails is of great importance to improve sheep production and welfare. In this Comment, …
Article scientifique
South African Lagerstätte reveals middle Permian Gondwanan lakeshore ecosystem in exquisite detail
Continental ecosystems of the middle Permian Period (273-259 million years ago) are poorly understood. In South Africa, the vertebrate fossil …
Article scientifique
Fossorial adaptations in African mole-rats (Bathyergidae) and the unique appendicular phenotype of naked mole-rats
Life underground has constrained the evolution of subterranean mammals to maximize digging performance. However, the mechanisms modulating morphological change and …
Article scientifique
Chimpanzees produce diverse vocal sequences with ordered and recombinatorial properties
The origins of human language remains a major question in evolutionary science. Unique to human language is the capacity to …
Article scientifique
Exome sequencing of families from Ghana reveals known and candidate hearing impairment genes
Abstract We investigated hearing impairment (HI) in 51 families from Ghana with at least two affected members that were negative …
Article scientifique
Global population genomic signature of Spodoptera frugiperda (fall armyworm) supports complex introduction events across the Old World
Native to the Americas, the invasive Spodoptera frugiperda (fall armyworm; FAW) was reported in West Africa in 2016, followed by …
Article scientifique
Seascapes of fear and competition shape regional seabird movement ecology
Fear effects of predators on prey distributions are seldom considered in marine environments, especially over large spatial scales and in …
Article scientifique
Non-proteolytic ubiquitylation in cellular signaling and human disease
Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins that frequently targets substrates for proteasomal degradation. However …
Article scientifique
Trans cohort metabolic reprogramming towards glutaminolysis in long-term successfully treated HIV-infection
Despite successful combination antiretroviral therapy (cART), persistent low-grade immune activation together with inflammation and toxic antiretroviral drugs can lead to …
Article scientifique
Identifying spatio-temporal seizure propagation patterns in epilepsy using Bayesian inference
Focal drug resistant epilepsy is a neurological disorder characterized by seizures caused by abnormal activity originating in one or more …
Article scientifique
Past environmental changes affected lemur population dynamics prior to human impact in Madagascar
Quaternary climatic changes have been invoked as important drivers of species diversification worldwide. However, the impact of such changes on …
Article scientifique
Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria
Abstract Antibody-mediated opsonic phagocytosis (OP) of Plasmodium falciparum blood-stage merozoites has been associated with protection against malaria. However, the precise …
Article scientifique
Cuticular hydrocarbons are associated with mating success and insecticide resistance in malaria vectors
Anopheles coluzzii females, important malaria vectors in Africa, mate only once in their lifetime. Mating occurs in aerial swarms with …
Article scientifique
High concentrations of dissolved biogenic methane associated with cyanobacterial blooms in East African lake surface water
Abstract The contribution of oxic methane production to greenhouse gas emissions from lakes is globally relevant, yet uncertainties remain about …
Article scientifique
The origin of island populations of the African malaria mosquito, Anopheles coluzzii
Abstract Anopheles coluzzii is a major malaria vector throughout its distribution in west-central Africa. Here we present a whole-genome study …
Article scientifique
PANDAA intentionally violates conventional qPCR design to enable durable, mismatch-agnostic detection of highly polymorphic pathogens
Sensitive and reproducible diagnostics are fundamental to containing the spread of existing and emerging pathogens. Despite the reliance of clinical …
Article scientifique
Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies
The mitogen-activated protein kinase (MAPK) pathways are crucial regulators of the cellular processes that fuel the malignant transformation of normal …
Article scientifique
Fairy circles in Namibia are assembled from genetically distinct grasses
Fairy circles are striking regularly sized and spaced, bare circles surrounded by Stipagrostis grasses that occur over thousands of square …