24 publication(s) trouvée(s)
Article scientifique
Prognostic utility of macrophage polarization (CD68/CD163 ratio) in Egyptian JAK2 positive myeloproliferative neoplasm patients: a single center study
BACKGROUND: Myeloproliferative neoplasms (MPNs) are clonal hematopoietic disorders with variable clinical outcomes influenced by the bone marrow microenvironment. Tumor-associated macrophages …
Article scientifique
OCT4 and MENA immunoprofiling in salivary mucoepidermoid carcinoma
BACKGROUND: Mucoepidermoid carcinoma (MEC) emblematizes the predominant malignant salivary gland neoplasm, characterized by its heterogeneous morphological features and diverse clinical …
Article scientifique
Immunohistochemical profile of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) versus other thyroid follicular lesions
BACKGROUND: A follicular thyroid tumour called Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) poses crossing-over morphologic characteristics with …
Article scientifique
A collaborative immunohistochemical study of Drp1 and cortactin in the epithelial dysplasia and oral squamous cell carcinoma
OBJECTIVES: Oral squamous cell carcinoma (OSCC) accounts for more than 90% of oral malignancies. The poorly understood molecular and cellular …
Article scientifique
Microsecretory adenocarcinoma: simplifying the diagnosis of a recently recognized salivary gland and cutaneous adnexal neoplasm
BACKGROUND: Microsecretory adenocarcinoma (MSA) is a newly identified entity in the WHO classification of salivary gland tumors characterized by MEF2C::SS18 …
Article scientifique
Diagnostic insights into solid pseudopapillary neoplasms of the pancreas: a decade of experience with pediatric representation
BACKGROUND: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare, low-grade malignancies that predominantly affect young females. Their diagnosis is …
Article scientifique
Immunohistochemical expression of parathyroid hormone-related protein and ezrin in invasive breast carcinoma of no special type: a retrospective analysis
BACKGROUND: Globally, breast cancer ranks among the most common malignancies and has a high mortality rate. Invasive breast carcinoma of …
Article scientifique
Histopathological spectrum of primordial odontogenic tumor with co-existing dentigerous cyst: 1st reported case of the world with a proposed ‘updated diagnostic criteria’
BACKGROUND: POT is a relatively newly described benign odontogenic tumor with very few cases registered to date. We present the …
Article scientifique
HOXA9 and CD163 potentiate pancreatic ductal adenocarcinoma progression
BACKGROUND: The role of HOXA9 requires investigations in pancreatic ductal adenocarcinoma (PDAC) as HOXA9 inhibitors are being developed. HOXA9 might …
Article scientifique
A rare adult case of primary uterine rhabdomyosarcoma with mixed pattern: a clinicopathological & immunohistochemical study with literature review
BACKGROUND: Rhabdomyosarcomas are aggressive tumors that comprise a group of morphologically similar but biologically diverse lesions. Owing to its rarity, …
Article scientifique
Evaluation of ARK5 and SIRT3 expression in renal cell carcinoma and their clinical significance
BACKGROUND: Globally Renal Cell Carcinoma (RCC) represents 3% of malignant tumours in adults and 1.78% in Egypt. AMPK-related protein kinase …
Article scientifique
Clinicopathological correlation of Cathepsin K expression in salivary gland carcinomas; relation to patients` outcome
BACKGROUND: Salivary gland carcinomas (SGCs) represent various groups of tumors that demonstrate marked diversity in their prognosis owing to different …
Article scientifique
Immunohistochemical based molecular subtypes of muscle-invasive bladder cancer: association with HER2 and EGFR alterations, neoadjuvant chemotherapy response and survival
Muscle-invasive bladder cancers (MIBCs) is a group of molecularly heterogonous diseases that could be stratified into subtypes with distinct clinical …
Article scientifique
A tonsillar location of a malignant schwannoma: a case report
INTRODUCTION: Malignant schwannoma is a malignant tumor of differentiation of Schwann cells or perineural cells. OBSERVATION: The patient was a …
Article scientifique
Molecular characterization of CTNS mutations in Tunisian patients with ocular cystinosis
BACKGROUND: Ocular cystinosis is a rare autosomal recessive disorder characterized by intralysosomal cystine accumulation in renal, ophthalmic (cornea, conjunctiva), and …
Article scientifique
RRM2 expression in different molecular subtypes of breast cancer and its prognostic significance
BACKGROUND: Breast cancer is one of the most common types of cancer. Ribonucleotide reductase (RNR) is a heterodimeric tetramer consisting …
Article scientifique
Hyperplastic polyp or sessile serrated lesion? The contribution of serial sections to reclassification
BACKGROUND: The histological discrimination of hyperplastic polyps from sessile serrated lesions can be difficult. Sessile serrated lesions and hyperplastic polyps …
Article scientifique
Ovarian cancer: diagnostic accuracy and tumor types distribution in East Africa compared to North America
BACKGROUND: Ovarian cancer is a spectrum of several histologically distinct tumor types that differ in etiology, response to therapy, and …
Article scientifique
Stromal osseous metaplasia in urothelial carcinoma of the bladder: a rare case report and literature review
BACKGROUND: The bone formation within bladder tumors could be encountered in 3 conditions. These might consist of malignant bone formation …
Article scientifique
Focused scores enable reliable discrimination of small differences in steatosis
BACKGROUND: Automated image analysis enables quantitative measurement of steatosis in histological images. However, spatial heterogeneity of steatosis can make quantitative …
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