185 publication(s) trouvée(s)
Article scientifique
Essential oil-based hydrogels for oral candidiasis: preliminary formulation development, antifungal efficacy, and computational analysis via Monte Carlo simulation
Introduction This study aimed to evaluate the inhibitory activity of the essential oils (EOs) of Syzygium aromaticum (formerly Eugenia caryophyllata …
Article scientifique
Repurposing approved drugs targeting Leishmania infantum 5-Methylthioadenosine Phosphorylase as anti-leishmanial candidates
Introduction Drug repurposing is a promising strategy for identifying new treatments against neglected tropical diseases such as leishmaniases, which are …
Article scientifique
Proteomic signatures of COVID-19 Post-Vaccination/Post-Infection Syndrome (PV/PIS): insights into immune dysregulation and coagulopathy
Introduction During the global rollout of COVID-19 vaccines, a subset of individuals reported persistent symptoms following vaccination, with clinical presentations …
Article scientifique
Genomic characterisation and antimicrobial resistance of Klebsiella species isolated from small stock and environmental sources in South Africa
Klebsiella species pose a significant public health concern due to their association with various infections and the rising levels of …
Article scientifique
Dose-dependent immune modulation in arboviral coinfections among febrile patients
Background: Arboviruses pose substantial diagnostic and public health challenges in tropical regions where multiple pathogens co-circulate. Nigeria, with diverse ecological …
Article scientifique
Development of a rapid, simple multiplex PCR-dipstick assay for the detection of Neisseria meningitidis serogroups in clinical isolates
The rapid identification and serogrouping of Neisseria meningitidis are crucial for effectively managing invasive meningococcal disease (IMD) patients and their …
Éditorial
Editorial: Transmission dynamics and population genomics of superbug pathogens of public health importance
Antimicrobial-resistant and high-risk bacterial pathogens are shaped by processes operating across multiple biological and epidemiological scales: genetic variation within pathogen …
Article scientifique
Integrated surveillance in Kilifi reveals continued SARS-CoV-2 circulation and immune escape of emerging JN.1 sublineages post-pandemic
Introduction: SARS-CoV-2 has been deprioritized post-pandemic, especially in Africa. Vaccination in Kenya was conducted using the Wuhan-based vaccines only, which …
Article scientifique
Genomic insights and evaluation of Bacillus spizizenii Endophyte from Solanum elaeagnifolium Cav against multidrug-resistant pathogens
Secondary metabolites are promising alternatives due to their diverse biological activities, including antimicrobial and antiviral effects. Wild plants, particularly Solanum …
Article scientifique
Molecular chaperones at the host–virus interface: heat shock protein roles in HIV-1 and emerging insights for HIV-2 and dual infection
Heat shock proteins (HSPs) are essential molecular chaperones involved in protein folding, cellular stress responses, and homeostasis. Recent studies reveal …
Article scientifique
Uncovering the potential virulence factors of emerging pathogens using AI/ML-based tools: a case study in Emergomyces africanus
Background We are currently in the era of artificial intelligence (AI), which has become deeply embedded across nearly all scientific …
Article scientifique
Combating antimicrobial resistance in Africa: a strategic roadmap for surveillance, stewardship, and research
Africa stands at a pivotal moment in public health: the continent faces a high and growing burden of infectious diseases …
Article scientifique
Recent advances in host models in studying virulence factors and pathogenesis of Acinetobacter baumannii
Acinetobacter baumannii is a major global healthcare-associated pathogen with increased antibiotic resistance, underscoring the urgent need to develop novel antibiotics, …
Article scientifique
Thymoquinone/β-N-acetylglucosaminidase, a novel plant-derived combination, inhibited quorum sensing signaling pathways and disrupted biofilm in Staphylococcus aureus
Background Disrupting Staphylococcus aureus S. aureus biofilms is of utmost importance in the medical field. Identifying herbal compounds, especially those …
Article scientifique
Classification and regulatory interactions of key transcription factors in COVID-19
SARS-CoV-2, the virus responsible for COVID-19, interferes with the host's transcriptional control systems, triggering widespread disruption of immune regulation and …
Article scientifique
Plasmodium telomere maintenance: uncovering the Achilles’ heel for novel antimalarials
This review examines the potential of disrupting telomere maintenance in Plasmodium as a novel antimalarial strategy. Telomeres are repetitive DNA–protein …
Article scientifique
Population structure and emergence of resistance to new and repurposed drugs in XDR-TB: insights from a 10-year genomic study in the Western Cape, South Africa review
Background: Extensively drug-resistant tuberculosis (XDR-TB) is a global health threat, being expensive and difficult to treat, with high mortality rates. …
Article scientifique
A one health perspective on multidrug-resistant bacterial infections: integrated approaches for surveillance, policy and innovation
Multidrug-resistant (MDR) bacterial infections represent a growing global health emergency, driven by interconnected human, animal, and environmental factors. This review …
Article scientifique
CRISPR typing and phage content of colonizing Group B Streptococci from healthy Egyptian women
Background: (GBS) causes serious infections in neonates with a particularly high burden of disease in Africa. Maternal vaginal colonization is …
Éditorial
Editorial: Controlling biofilm-related infections in healthcare settings
Corresponding author: satwa@msa.edu.eg Biofilm formation by clinically significant pathogens presents a substantial global public health challenge, particularly due to its …