185 publication(s) trouvée(s)
Article scientifique
Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activity Against Mycobacterium tuberculosis
Compounds with novel modes of action are urgently needed to develop effective combination therapies for the treatment of tuberculosis. In …
Article scientifique
Cell Surface Biosynthesis and Remodeling Pathways in Mycobacteria Reveal New Drug Targets
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains the leading cause of death from an infectious bacterium and …
Article scientifique
Molecular Identification of Secreted Effector Genes Involved in African Fusarium oxysporum f.sp. elaeidis Strains Pathogenesis During Screening Nigerian Susceptible and Tolerant Oil Palm (Elaeis guineensis Jacq.) Genotypes
Fusarium wilt is caused by Fusarium oxysporum f.sp. elaeidis, and constitutes a severe threat to the oil palm industry in …
Article scientifique
Quantitative Visions of Reality at the Tick-Host Interface: Biochemistry, Genomics, Proteomics, and Transcriptomics as Measures of Complete Inventories of the Tick Sialoverse
Species have definitive genomes. Even so, the transcriptional and translational products of the genome are dynamic and subject to change …
Article scientifique
Immunomodulation for the Treatment of Fungal Infections: Opportunities and Challenges
Opportunistic fungal infections are major causes of morbidity and mortality in patients with single or multiple defects in their immunity. …
Article scientifique
Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy
Tuberculosis (TB) kills more people every year than any other infectious agent. This epidemic is exacerbated by the ongoing development …
Article scientifique
Determinants of Vaginal Microbiota Composition
There is increasing evidence that the composition of a woman's vaginal microbiota significantly influences her sexual and reproductive health, including …
Article scientifique
Investigating Non-sterilizing Cure in TB Patients at the End of Successful Anti-TB Therapy
(Mtb) is extremely recalcitrant to antimicrobial chemotherapy requiring 6 months to treat drug-sensitive tuberculosis (TB). Despite this, 4-10% of cured …
Article scientifique
Placental Microbial Colonization and Its Association With Pre-eclampsia
The existence and role of the microbiome in regulating physiological and pathophysiological conditions including metabolism, energy homeostasis, immune tolerance, behavior, …
Article scientifique
Bacterial Vaginosis: Current Diagnostic Avenues and Future Opportunities
A healthy female genital tract harbors a microbiome dominated by lactic acid and hydrogen peroxide producing bacteria, which provide protection …
Article scientifique
Proteus mirabilis Biofilm: Development and Therapeutic Strategies
Proteus mirabilis is a Gram negative bacterium that is a frequent cause of catheter-associated urinary tract infections (CAUTIs). Its ability …
Article scientifique
The Vaginal Microbiota Among Adolescent Girls in Tanzania Around the Time of Sexual Debut
The aetiology of bacterial vaginosis (BV) is not well understood, and prevalence appears to be higher among women living in …
Article scientifique
Molecular Characterization and Immuno-Reactivity Patterns of a Novel Plasmodium falciparum Armadillo-Type Repeat Protein, PfATRP
Nearly half of the genes in the Plasmodium falciparum genome have not yet been functionally investigated. We used homology-based structural …
Article scientifique
Distinct Human NK Cell Phenotypes and Functional Responses to Mycobacterium tuberculosis in Adults From TB Endemic and Non-endemic Regions
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), which leads to an estimated 1.5 million deaths worldwide each …
Article scientifique
Growth Forms of Gardnerella spp. and Lactobacillus spp. on Vaginal Cells
Bacterial vaginosis (BV) is a common vaginal condition in women of reproductive age. During BV development, BV-associated bacteria may form …
Article scientifique
How the Cervical Microbiota Contributes to Cervical Cancer Risk in Sub-Saharan Africa
Despite ongoing efforts, sub-Saharan Africa faces a higher cervical cancer burden than anywhere else in the world. Besides HPV infection, …
Article scientifique
Inflammatory Dendritic Cells, Regulated by IL-4 Receptor Alpha Signaling, Control Replication, and Dissemination of Leishmania major in Mice
Leishmaniasis is a vector-borne disease caused by Leishmania parasites. Macrophages are considered the primary parasite host cell, but dendritic cells …
Article scientifique
Cerebrospinal Fluid-Derived Microvesicles From Sleeping Sickness Patients Alter Protein Expression in Human Astrocytes
Human African trypanosomiasis (HAT) caused by the extracellular protozoon Trypanosoma brucei, is a neglected tropical disease affecting the poorest communities …
Article scientifique
IFNL4 Genotypes Predict Clearance of RNA Viruses in Rwandan Children With Upper Respiratory Tract Infections
Polymorphisms in the interferon lambda gene locus (IFNL) such as the IFNL4 genetic variants rs12979860 and rs368234815 are predictive of …
Article scientifique
The First Isolation and Molecular Characterization of Shiga Toxin-Producing Virulent Multi-Drug Resistant Atypical Enteropathogenic Escherichia coli O177 Serogroup From South African Cattle
Atypical enteropathogenic E. coli (aEPEC) is a group of diarrhoeagenic Escherichia coli with high diversity of serotypes, which lack the …