192 publication(s) trouvée(s)
Article scientifique
A review on extraction, isolation, characterization of bioactive compounds obtained from agri-food waste and their potential for industrial application
The increased global food demand has resulted into extensive agricultural activities to offset the demand. The agri-activities generates large volumes …
Article scientifique
Targeting RNA-binding proteins with small molecules: perspectives and challenges
RNA-binding proteins (RBPs) play critical roles in numerous biological processes because they regulate RNA function by directly interacting with RNA …
Article scientifique
Sustainable biosynthesis, physiochemical characterization, cytotoxicity, and antimicrobial evaluation of novel chromium oxide nanoparticles
The biosynthesis of nanoparticles (NPs) has attracted significant interest due to their diverse biological applications. However, the potential for NPs …
Article scientifique
Nutraceutical potential of moroccan Juglans regia: phytochemical profiling and multi-modal evaluation of bioactivities
This study explores the therapeutic potential of J. regia from Morocco through an in-depth phytochemical analysis and biological evaluations using …
Article scientifique
Design, synthesis, and biological assessment of a novel series of coumarin-tethered thiazole derivatives as potential antibacterial agents
Since the discovery of penicillin in the 1930s, antibiotics have been the primary treatment for bacterial infections. However, antimicrobial resistance …
Article scientifique
Comprehensive synthesis and characterization of a novel Fe–porphyrin complex: crystal structure, spectroscopic investigations, Hirshfeld surface analysis, and computational modeling (DFT, QTAIM-NCI/ELF)
In this work, we prepared the novel (η1-hydrogencarbonato) iron (II) picket-fence porphyrin with the formula [K (2,2,2-crypt)][FeII(TpivPP) (η1-HCO3)] (I) (where …
Article scientifique
Discovery of N′-(1-(coumarin-3-yl)ethylidene)benzenesulfonohydrazide as a novel wound healing enhancer: synthesis, biological assessment, and molecular modeling
Wound healing poses a considerable challenge in the domain of medical science. In modern clinical practice, there is a growing …
Article scientifique
Citrus aurantifolia essential oil: antiaging potential through integrated in vitro and in silico studies
Introduction Natural skincare products and cosmetic preparations have gained popularity among consumers in recent years, prompting cosmetic companies to develop …
Article scientifique
In silico design of novel dihydropteridone derivatives with oxadiazoles as potent inhibitors of MCF-7 breast cancer cells
Introduction: Pharmaceutical treatment protocols or combination therapies based on chemical compounds make it possible to target cancer cells, which can …
Article scientifique
Synthesis, X-ray crystallography, spectroscopic characterizations, and density functional theory of the chloride-bound five-coordinate high-spin Iron(II) “Picket Fence” porphyrin complex
An Fe(II)-chlorido five-coordinate picket fence porphyrin complex with the formula [K (crypt-222)][FeII(TpivPP)Cl]·C6H5Cl (I) (where TpivPP is the picket fence porphyrin …
Article scientifique
Metabolomics, antioxidant, and enzyme inhibitory effects of Citrus aurantium fruits
Introduction: comprises a large number of economically important fruit crops. They are recognized globally as functional foods and in the …
Article scientifique
In silico molecular studies of Phosphinogold(I) thiocarbohydrate complexes: insights into multi-target anticancer mechanisms
Introduction: This study employed in silico methods to investigate the anticancer potential and mechanisms of twenty novel phosphinogold(I) thiocarbohydrate complexes. …
Article scientifique
Ruta montana L. from Morocco: comprehensive phytochemical analysis and exploration of its antioxidant, antimicrobial, anti-inflammatory and analgesic properties
Ruta montana L., a medicinal plant native to Morocco's Middle Atlas region, has been traditionally used for its therapeutic properties. …
Article scientifique
Synthesis and characterization of thymol-derived phenoxy acetamide derivatives using DFT, molecular docking, and parasitological investigations
Novel phenoxy acetamide derivatives based on a thymol moiety were synthesized for target parasitological investigation. The newly synthesized compounds, 5a, …
Article scientifique
Development of nifedipine isosteres: an integrated approach to the design, synthesis, and biological assessment of calcium channel blockers
This study reports the synthesis of a series of calcium channel blockers via Biginelli’s reaction. The core dihydropyridine (DHP) scaffold, …
Article scientifique
Design of novel pyrazole and benzofuran-based derivatives as potent acetylcholinesterase inhibitors for Alzheimer’s disease management
Introduction: Being a complex neurodegenerative disease with many clinical features, Alzheimer's disease calls for multiple-targeted drugs to treat several aspects …
Article scientifique
Engineering high-performance CTAB-functionalized magnesium silicate nano-adsorbent for efficient removal of Cd2+, Co2+, and Cu2+ from single-metal aqueous solutions
The development of highly efficient, recyclable adsorbents for heavy metal remediation remains a critical challenge in environmental engineering. This study …
Article scientifique
Effective and realistic sequestration of Sr2+ and B3+ ions from the aqueous environments using coral reefs based Ca-MCM-41: Gulf of Suez as case study
A mesoporous calcium-bearing siliceous framework (Ca-MCM-41) was synthesized using natural coral reef carbonate rocks as precursors. The structural characterization, confirmed …
Article scientifique
Antioxidant activity and selective cytotoxicity in HCT-116 and WI-38 cell lines of LC-MS/MS profiled extract from Capparis spinosa L
Introduction Capparis spinosa L. is significant among the family Capparidaceae for its survival and tolerance to dry environments. In this …
Article scientifique
Design, synthesis, in silico studies, and apoptotic antiproliferative activity of novel thiazole-2-acetamide derivatives as tubulin polymerization inhibitors
Introduction Tubulin polymerization inhibitors have emerged as interesting anticancer therapies. We present the design, synthesis, and structural elucidation of novel …