227 publication(s) trouvée(s)
Article scientifique
Molecular Profiling of Kenyan Acute Myeloid Leukemia Patients
Acute myeloid leukemia (AML) is an infrequent disease, and it is associated with high morbidity and mortality. It harbors a …
Article scientifique
Case Report: A New Family With Pontocerebellar Hypoplasia 10 From Sudan
Pontocerebellar hypoplasia type 10 (PCH10) is a very rare autosomal recessive neurodegenerative disease characterized by intellectual disability, microcephaly, severe developmental …
Article scientifique
Skills Capacity Building For Health Care Services and Research Through the Sickle Pan African Research Consortium
Skills development, the building of human capacity, is key to any sustainable capacity building effort, however, such undertakings require adaptable …
Article scientifique
Whole Exome Sequencing in South Africa: Stakeholder Views on Return of Individual Research Results and Incidental Findings
The use of whole exome sequencing (WES) in medical research is increasing in South Africa (SA), raising important questions about …
Article scientifique
rs401502 and rs11575934 Polymorphisms of the IL-12 Receptor Beta 1 Gene are Protective Against Colorectal Carcinogenesis
Background: Colorectal cancer (CRC) is a major public health problem worldwide and in Tunisia. It ranks among the main cancers …
Article scientifique
African Genetic Representation in the Context of SARS-CoV-2 Infection and COVID-19 Severity
The original publication is available at https://www.frontiersin.org/
Article scientifique
Genomics in Egypt: Current Status and Future Aspects
Egypt is the third most densely inhabited African country. Due to the economic burden and healthcare costs of overpopulation, genomic …
Article scientifique
The Effect of miRNA Gene Regulation on HIV Disease
Over many years, research on HIV/AIDS has advanced with the introduction of HAART. Despite these advancements, significant gaps remain with …
Erratum
Corrigendum: Apolipoprotein E Genetic Variation and its Association With Cognitive Function in Rural-Dwelling Older South Africans
Corrigendum on: Soo CC, Farrell MT, Tollman S, Berkman L, Nebel A and Ramsay M (2021) Apolipoprotein E Genetic Variation …
Article scientifique
Hepatic Models in Precision Medicine: An African Perspective on Pharmacovigilance
Pharmaceuticals are indispensable to healthcare as the burgeoning global population is challenged by diseases. The African continent harbors unparalleled genetic …
Article scientifique
Individualized Medicine in Africa: Bringing the Practice Into the Realms of Population Heterogeneity
The declared aim of "personalized", "stratified" or "precision" approaches is to place individual variation, as ascertained through genomic and various …
Article scientifique
Prevalence of Hemoglobin-S and Baseline Level of Knowledge on Sickle Cell Disease Among Pregnant Women Attending Antenatal Clinics in Dar-Es-Salaam, Tanzania
Background: Sickle cell disease (SCD) is the single most important genetic cause of childhood mortality globally. Newborn screening (NBS) is …
Article scientifique
Microbiomics: The Next Pillar of Precision Medicine and Its Role in African Healthcare
Limited access to technologies that support early monitoring of disease risk and a poor understanding of the geographically unique biological …
Éditorial
Editorial: Genetics of Apicomplexans and Apicomplexan-Related Parasitic Diseases
Genetics of Apicomplexans and Apicomplexan-Related Parasitic DiseasesApicomplexa are a large phylum of parasitic organisms.They are mostly unicellular and sporeforming in …
Article scientifique
Esophageal Cancer Genomics in Africa: Recommendations for Future Research
Limited Number of Genomic Studies on ESCC in AfricaThere is an apparent lack of genomic studies on ESCC on African …
Article scientifique
Copy Number Variations in Genetic Diagnosis of Congenital Adrenal Hyperplasia Children
Background: Congenital adrenal hyperplasia (CAH) is a monogenic disorder caused by genetic diversity in the CYP21A2 gene, with 21-hydroxylase deficiency …
Article scientifique
Current Status of Next-Generation Sequencing Approaches for Candidate Gene Discovery in Familial Parkinson´s Disease
Parkinson’s disease is a neurodegenerative disorder with a heterogeneous genetic etiology. The advent of next-generation sequencing (NGS) technologies has aided …
Article scientifique
Outcome of Hydroxyurea Use in SCD and Evaluation of Patients’ Perception and Experience in Nigeria
Introduction: Hydroxyurea (HU) has been shown to be beneficial in the management of sickle cell disease (SCD) as it improves …
Article scientifique
Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions
There are a plethora of cancer causes and the road to fully understanding the carcinogenesis process remains a dream that …
Article scientifique
Adiponectin and Disease Severity in Sickle Cell Anemia Patients Attending a Tertiary Health Institution in Nnewi, Southeast Nigeria
Background: Hemoglobin polymerization in sickle cell anemia (SCA) leads to abnormally rigid and adhesive erythrocytes that obstruct blood vessels, leading …