227 publication(s) trouvée(s)
Éditorial
Editorial: Implementation of genomic medicine in Africa: One continent, one vision
Implementation of genomic medicine in Africa: One continent, one visionThe translation of genetic research from bench to bedside involves multiple …
Article scientifique
Case report: 7p22.3 deletion and 8q24.3 duplication in a patient with epilepsy and psychomotor delay—Does both possibly act to modulate a candidate gene region for the patient’s phenotype?
Background: Psychomotor delay, epilepsy and dysmorphic features are clinical signs which are described in multiple syndromes due to chromosomal imbalances …
Article scientifique
Mapping quantitative trait loci and predicting candidate genes for Striga resistance in maize using resistance donor line derived from Zea diploperennis
The parasitic weed, Striga is a major biological constraint to cereal production in sub-Saharan Africa (SSA) and threatens food and …
Article scientifique
Genetic and phenotypic correlations among feed efficiency, immune and production traits in indigenous chicken of Kenya
This study aimed at estimating genetic and phenotypic relationships among feed efficiency, immune and production traits measured pre- (9–20 weeks …
Article scientifique
Selection signature analysis and genome-wide divergence of South African Merino breeds from their founders
Merino sheep are a breed of choice across the world, popularly kept for their wool and mutton value. They are …
Article scientifique
Development of multi-level standards of care recommendations for sickle cell disease: Experience from SickleInAfrica
Introduction:Sickle Cell Disease (SCD) causes significant morbidity and mortality particularly in sub-Saharan Africa (SSA) where it contributes to early childhood …
Article scientifique
Secondary metabolites produced by endophytic fungi, Alternaria alternata, as potential inhibitors of the human immunodeficiency virus
Antiretroviral treatment has significantly reduced human immunodeficiency virus infection and mortality. However, the current treatment regimen is limited by adverse …
Article scientifique
Establishing a database for sickle cell disease patient mapping and survival tracking: The sickle pan-african research consortium Nigeria example
Background: The Sickle Pan-African Research Consortium (SPARCO) and Sickle Africa Data Coordinating Center (SADaCC) were set up with funding from …
Article scientifique
The multidimensional legal nature of personal genomic sequence data: A South African perspective
This article provides a comprehensive analysis of the various dimensions in South African law applicable to personal genomic sequence data. …
Article scientifique
Benefit sharing in genomic and biobanking research in Uganda: Perceptions of researchers and research ethics committee members
Background: Genomic and biobanking research has increased in Africa over the past few years. This has raised pertinent ethical, legal, …
Article scientifique
Rethinking benefit sharing in collaborative human genetic research from an Afrocommunitarian perspective
This article draws on reflections about humanness, friendliness and partiality, in the writings of Afro-communitarians to develop principles for thinking …
Article scientifique
Prevalence, antibiotic profile, virulence determinants, ESBLs, and non-β-lactam encoding genes of MDR Proteus spp. isolated from infected dogs
This study investigated the prevalence, antibiogram, virulence, extended-spectrum β-lactamases (ESBLs), and non-β-lactam encoding genes of Proteus species isolated from infected …
Article scientifique
Genome-wide SNP analysis of Plasmodium falciparum shows differentiation at drug-resistance-associated loci among malaria transmission settings in southern Mali
Plasmodium falciparum malaria cases in Africa represent over 90% of the global burden with Mali being amongst the 11 highest …
Article scientifique
Using dried blood spot on HemoTypeSC™, a new frontier for newborn screening for sickle cell disease in Nigeria
Background: HemoTypeSC is a rapid, point-of-care testing (POCT) device for sickle cell disease (SCD) that traditionally uses the capillary blood …
Article scientifique
Improving drought tolerance in maize: Tools and techniques
Drought is an important constraint to agricultural productivity worldwide and is expected to worsen with climate change. To assist farmers, …
Éditorial
Editorial: Cholesterol and cancer drug resistance: Molecular, signaling, and therapeutic aspects
Editorial on the Research Topic Cholesterol and Cancer drug resistance: Molecular, signalling and therapeutic aspects Cancer was responsible for approximately …
Article scientifique
Pharmacogenomics of drug transporters for antiretroviral long-acting pre-exposure prophylaxis for HIV
[tenofovir disoproxil fumarate (TDF)/tenofovir (TFV) and emtricitabine (FTC)] as oral or topical PrEP in African women showed mixed results in …
Article scientifique
Cell-based analysis of CLIC5A and SLC12A2 variants associated with hearing impairment in two African families
We have previously reported CLIC5A and SLC12A2 variants in two families from Cameroon and Ghana, segregating non-syndromic hearing impairment (NSHI). …
Article scientifique
Insufficiency in functional genomics studies, data, and applications: A case study of bio-prospecting research in ruminant microbiome
Over the last two decades, biotechnology has advanced at a rapid pace, propelled by the incorporation of bio-products into various …
Article scientifique
Drosophila melanogaster: A platform for anticancer drug discovery and personalized therapies
Cancer is a complex disease whereby multiple genetic aberrations, epigenetic modifications, metabolic reprogramming, and the microenvironment contribute to the development …