227 publication(s) trouvée(s)
Article scientifique
Genetic Variations and Differential DNA Methylation to Face Contrasted Climates in Small Ruminants: An Analysis on Traditionally-Managed Sheep and Goats
The way in which living organisms mobilize a combination of long-term adaptive mechanisms and short-term phenotypic plasticity to face environmental …
Article scientifique
Associations Between CYP17A1 and SERPINA6/A1 Polymorphisms, and Cardiometabolic Risk Factors in Black South Africans
Research in European and Asian populations has reported associations between single nucleotide polymorphisms (SNPs) in CYP17A1 and SERPINA6/A1 and circulating …
Article scientifique
Identification of BRCA2 Cis Double Heterozygous Breast Cancer Cases Using Whole Exome Sequencing: Phenotypic Expression and Impact on Personalized Oncology
BRCA1 and BRCA2 are the most commonly mutated breast cancer susceptibility genes that convey a high risk of breast and …
Article scientifique
Rapid CRISPR/Cas9 Editing of Genotype IX African Swine Fever Virus Circulating in Eastern and Central Africa
African swine fever virus (ASFV) is the etiological agent of a contagious and fatal disease of domestic pigs that has …
Article scientifique
Search for Selection Signatures Related to Trypanosomosis Tolerance in African Goats
Livestock is heavily affected by trypanosomosis in Africa. Through strong selective pressure, several African indigenous breeds of cattle and small …
Article scientifique
The Impact of Single Nucleotide Polymorphism in the Long Non-coding MEG3 Gene on MicroRNA-182 and MicroRNA-29 Expression Levels in the Development of Breast Cancer in Egyptian Women
Early-stage detection of BC is a critical factor for effective treatment of the disease and can increase the survival rate …
Article scientifique
Antigenic Diversity in Theileria parva Populations From Sympatric Cattle and African Buffalo Analyzed Using Long Read Sequencing
East Coast fever (ECF) in cattle is caused by the Apicomplexan protozoan parasiteTheileria parva, transmitted by the three-host tickRhipicephalus appendiculatus. …
Article scientifique
Role of the kdpDE Regulatory Operon of Mycobacterium tuberculosis in Modulating Bacterial Growth in vitro
Bacteria use K+-uptake transporters differentially for adaptation in varying growth conditions. In Mycobacterium tuberculosis, two K+-uptake systems, the Trk comprising …
Article scientifique
Genome Divergence and Dynamics in the Thin-Tailed Desert Sheep From Sudan
With climate change bound to affect food and feed production, emphasis will shift to resilient and adapted indigenous livestock to …
Article scientifique
South African Buffalo-Derived Theileria parva Is Distinct From Other Buffalo and Cattle-Derived T. parva
Theileria parvais a protozoan parasite transmitted by the brown-eared ticks,Rhipicephalus appendiculatusandRhipicephalus zambeziensis. Buffaloes are the parasite’s ancestral host, with cattle …
Article scientifique
A Mix of Old British and Modern European Breeds: Genomic Prediction of Breed Composition of Smallholder Pigs in Uganda
Pig herds in Africa comprise genotypes ranging from local ecotypes to commercial breeds. Many animals are composites of these two …
Article scientifique
Chloroquine and Sulfadoxine–Pyrimethamine Resistance in Sub-Saharan Africa—A Review
Malaria is a great concern for global health and accounts for a large amount of morbidity and mortality, particularly in …
Article scientifique
Case Report: Identification of Novel Variants in ERCC4 and DDB2 Genes in Two Tunisian Patients With Atypical Xeroderma Pigmentosum Phenotype
Xeroderma Pigmentosum (XP) is a rare genetic disorder affecting the nucleotide excision repair system (NER). It is characterized by an …
Article scientifique
The 5-HTTLPR-rs25531 S-A-S-A Haplotype and Chronic Stress Moderate the Association Between Acute Stress and Internalizing Mental Disorders Among HIV+ Children and Adolescents in Uganda
Background: Internalizing mental disorders (IMDs) among HIV-positive (HIV+) children and adolescents are associated with poor disease outcomes, such as faster …
Article scientifique
Heterozygous Single-Nucleotide Polymorphism Genotypes at Heat Shock Protein 70 Gene Potentially Influence Thermo-Tolerance Among Four Zebu Breeds of Nigeria
Genetic variants at heat shock protein 70 gene and their influence on heat stress (HS) tolerance were studied among selected …
Article scientifique
Inference of Ancestries and Heterozygosity Proportion and Genotype Imputation in West African Cattle Populations
Several studies have evaluated computational methods that infer the haplotypes from population genotype data in European cattle populations. However, little …
Article scientifique
Investigations of Kidney Dysfunction-Related Gene Variants in Sickle Cell Disease Patients in Cameroon (Sub-Saharan Africa)
Background Renal dysfunctions are associated with increased morbidity and mortality in sickle cell disease (SCD). Early detection and subsequent management …
Article scientifique
Potential Impact of DPYD Variation on Fluoropyrimidine Drug Response in sub-Saharan African Populations
Cancer is a critical health burden in Africa, and mortality rates are rising rapidly. Treatments are expensive and often cause …
Article scientifique
FANCA Gene Mutations in North African Fanconi Anemia Patients
Populations in North Africa (NA) are characterized by a high rate of consanguinity. Consequently, the proportion of founder mutations might …
Article scientifique
Differential Gene Expression Patterns in Blood and Cerebrospinal Fluid of Multiple Sclerosis and Neuro-Behçet Disease
Inflammatory demyelinating disorders of the central nervous system are debilitating conditions of the young adult, here we focus on multiple …