227 publication(s) trouvée(s)
Article scientifique
Capture Sequencing to Explore and Map Rare Casein Variants in Goats
Genetic variations in the four casein genes CSN1S1, CSN2, CSN1S2, and CSN3 have obtained substantial attention since they affect the …
Article scientifique
Breed Ancestry, Divergence, Admixture, and Selection Patterns of the Simbra Crossbreed
In this study, we evaluated an admixed South African Simbra crossbred population, as well as the Brahman (Indicine) and Simmental …
Article scientifique
Technological Innovations for Improving Cassava Production in Sub-Saharan Africa
Cassava is crucial for food security of millions of people in sub-Saharan Africa. The crop has great potential to contribute …
Article scientifique
Identification of Novel BRCA1 and RAD50 Mutations Associated With Breast Cancer Predisposition in Tunisian Patients
Background Deleterious mutations on BRCA1/2 genes are known to confer high risk of developing breast and ovarian cancers. The identification …
Article scientifique
Schizophrenia Polygenic Risk and Brain Structural Changes in Methamphetamine-Associated Psychosis in a South African Population
BACKGROUND: The genetic architecture of psychotic disorders is complex, with hundreds of genetic risk loci contributing to a polygenic model …
Article scientifique
Candidate Gene Analysis Reveals Strong Association of CETP Variants With High Density Lipoprotein Cholesterol and PCSK9 Variants With Low Density Lipoprotein Cholesterol in Ghanaian Adults: An AWI-Gen Sub-Study
Variations in lipid levels are attributed partly to genetic factors. Genome-wide association studies (GWASs) mainly performed in European, African American …
Article scientifique
Integrating Genetic and Genomic Analyses of Combined Health Data Across Ecotypes to Improve Disease Resistance in Indigenous African Chickens
Poultry play an important role in the agriculture of many African countries. The majority of chickens in sub-Saharan Africa are …
Article scientifique
Toxicological Study and Genetic Basis of BTEX Susceptibility in Drosophila melanogaster
Benzene, toluene, ethylbenzene and xylene, also known as BTEX, are released into environmental media by petroleum product exploratory and exploitative …
Article scientifique
Next Generation Sequencing and Bioinformatics Analysis of Family Genetic Inheritance
Mendelian and complex genetic trait diseases continue to burden and affect society both socially and economically. The lack of effective …
Éditorial
Editorial: The Genetic and Environmental Basis for Diseases in Understudied Populations
EDITORIAL article Front. Genet., 23 September 2020Sec. Evolutionary and Population Genetics Volume 11 - 2020 | https://doi.org/10.3389/fgene.2020.559956
Article scientifique
A Department of Defense Laboratory Consortium Approach to Next Generation Sequencing and Bioinformatics Training for Infectious Disease Surveillance in Kenya
Epidemics of emerging and re-emerging infectious diseases are a danger to civilian and military populations worldwide. Health security and mitigation …
Article scientifique
Ethnic and Adipose Depot Specific Associations Between DNA Methylation and Metabolic Risk
Background Metabolic risk varies according to body mass index (BMI), body fat distribution and ethnicity. In recent years, epigenetics, which …
Article scientifique
Genetic Basis of Response of Ghanaian Local Chickens to Infection With a Lentogenic Newcastle Disease Virus
Newcastle disease (ND) is a global threat to domestic poultry, especially in rural areas of Africa and Asia, where the …
Article scientifique
DNA Methylation and Demethylation Are Regulated by Functional DNA Methyltransferases and DnTET Enzymes in Diuraphis noxia
Aphids are economically important insect pests of crops worldwide. Despite resistant varieties being available, resistance is continuously challenged and eventually …
Article scientifique
Ancestral Haplotype Mapping for GWAS and Detection of Signatures of Selection in Admixed Dairy Cattle of Kenya
Understanding the genetic structure of adaptation and productivity in challenging environments is necessary for designing breeding programs that suit such …
Article scientifique
Comparative (Within Species) Genomics of the Vitis vinifera L. Terpene Synthase Family to Explore the Impact of Genotypic Variation Using Phased Diploid Genomes
The Vitis vinifera L. terpene synthase (VviTPS) family was comprehensively annotated on the phased diploid genomes of three closely related …
Article scientifique
Combining QTL Analysis and Genomic Predictions for Four Durum Wheat Populations Under Drought Conditions
Durum wheat is an important crop for the human diet and its consumption is gaining popularity. In order to ensure …
Article scientifique
Genome Wide Assessment of Genetic Variation and Population Distinctiveness of the Pig Family in South Africa
Genetic diversity is of great importance and a prerequisite for genetic improvement and conservation programs in pigs and other livestock …
Article scientifique
Pioneering Informed Consent for Return of Research Results to Breast Cancer Patients Facing Barriers to Implementation of Genomic Medicine: The Kenyan BRCA1/2 Testing Experience Using Whole Exome Sequencing
Introduction: Obtaining informed consent from study participants and disseminating the findings responsibly is a key principle required for ethically conducted …
Article scientifique
Novel and Known Gene-Smoking Interactions With cIMT Identified as Potential Drivers for Atherosclerosis Risk in West-African Populations of the AWI-Gen Study
Atherosclerosis is a key contributor to the burden of cardiovascular diseases (CVDs) and many epidemiological studies have reported on the …