471 publication(s) trouvée(s)
Article scientifique
Case Report: FOXP3 Mutation in a Patient Presenting With ALPS
ALPS and IPEX are two well-characterized inborn errors of immunity with immune dysregulation, considered as two master models of monogenic …
Éditorial
Editorial: The Role of Platelet Activation in the Pathophysiology of HIV, Tuberculosis and Pneumococcal Disease
Platelets, best known as essential effector cells in coagulation and hemostasis, are increasingly recognized \nas major inflammatory cells that play …
Article scientifique
Clinical Features of HIV Arthropathy in Children: A Case Series and Literature Review
Background: HIV infection has been associated with a non-erosive inflammatory arthritis in children, although few published reports exist. This study …
Article scientifique
Patterns of Immune Activation in HIV and Non HIV Subjects and Its Relation to Cardiovascular Disease Risk
Introduction: Insight into inflammation patterns is needed to understand the pathophysiology of HIV and related cardiovascular disease (CVD). We assessed …
Article scientifique
Thrombosis in Psoriasis: Cutaneous Cytokine Production as a Potential Driving Force of Haemostatic Dysregulation and Subsequent Cardiovascular Risk
Psoriasis (PsO) is a common T cell-mediated inflammatory disorder of the skin with an estimated prevalence of 2%. The condition …
Article scientifique
Immune Checkpoint Inhibitors in Human Glioma Microenvironment
Gliomas are the most common primary brain tumors in adults. Despite the fact that they are relatively rare, they cause …
Article scientifique
Immunogenicity and Efficacy of Pneumococcal Conjugate Vaccine (Prevenar13®) in Preventing Acquisition of Carriage of Pneumococcal Vaccine Serotypes in Tanzanian Children With HIV/AIDS
In every year, up to one million children die due to pneumococcal disease. Children infected with Human Immunodeficiency Virus (HIV) …
Article scientifique
Altered Ex-Vivo Cytokine Responses in Children With Asymptomatic Plasmodium falciparum Infection in Burkina Faso: An Additional Argument to Treat Asymptomatic Malaria?
Introduction Patients with clinical malaria have an increased risk for bacterial bloodstream infections. We hypothesized that asymptomatic malaria parasitemia increases …
Article scientifique
The Frequency and Effect of Granulocytic Myeloid-Derived Suppressor Cells on Mycobacterial Survival in Patients With Tuberculosis: A Preliminary Report
Introduction Protective host responses in those exposed to or infected with tuberculosis (TB) is thought to require a delicate balance …
Article scientifique
Case Report: Allergic Bronchopulmonary Aspergillosis Revealing Asthma
Allergic bronchopulmonary aspergillosis (ABPA) is an immunological pulmonary disorder caused by hypersensitivity to Aspergillus which colonizes the airways of patients …
Article scientifique
Case Report: Interleukin-2 Receptor Common Gamma Chain Defect Presented as a Hyper-IgE Syndrome
X-linked severe combined immunodeficiency (X-SCID) is caused by mutations of IL2RG, the gene encoding the interleukin common gamma chain (IL-2Rγ …
Article scientifique
IL-4-Responsive B Cells Are Detrimental During Chronic Tuberculosis Infection in Mice
In tuberculosis, T cell-mediated immunity is extensively studied whilst B cells received limited attention in human and mice. Of interest, …
Article scientifique
Dysregulation of the Immune Environment in the Airways During HIV Infection
HIV-1 increases susceptibility to pulmonary infection and disease, suggesting pathogenesis in the lung. However, the lung immune environment during HIV …
Article scientifique
Something Old, Something New: Ion Channel Blockers as Potential Anti-Tuberculosis Agents
Tuberculosis (TB) remains a challenging global health concern and claims more than a million lives every year. We lack an …
Article scientifique
SFRP5 Enhances Wnt5a Induced-Inflammation in Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Background Tissue derived fibroblast-like synoviocytes (td-FLS) are key actors in pannus formation and contribute to joint destruction and inflammation during …
Article scientifique
Recent Semen Exposure Impacts the Cytokine Response and Bacterial Vaginosis in Women
Background The presence of semen in the vagina from unprotected sex may influence the immune and microbial environment of the …
Article scientifique
From Mesenchymal Stromal/Stem Cells to Insulin-Producing Cells: Immunological Considerations
Mesenchymal stem cell (MSC)-based therapy for type 1 diabetes mellitus (T1DM) has been the subject matter of many studies over …
Article scientifique
Multiple Country and Breed Genomic Prediction of Tick Resistance in Beef Cattle
Ticks cause substantial production losses for beef and dairy cattle. Cattle resistance to ticks is one of the most important …
Article scientifique
Are Fc Gamma Receptor Polymorphisms Important in HIV-1 Infection Outcomes and Latent Reservoir Size?
Fc gamma receptors (FcγR) are cell surface glycoproteins which trigger specific effector-cell responses when cross-linked with the Fc portions of …
Article scientifique
Epigenetic Regulation of BST-2 Expression Levels and the Effect on HIV-1 Pathogenesis
HIV-1 must overcome host antiviral restriction factors for efficient replication. We hypothesized that elevated levels of bone marrow stromal cell …