471 publication(s) trouvée(s)
Article scientifique
Diversity of Dysregulated Long Non-Coding RNAs in HBV-Related Hepatocellular Carcinoma
Infection with the hepatitis B virus (HBV) continues to pose a major threat to public health as approximately 292 million …
Article scientifique
The Interplay Between Neuroinfections, the Immune System and Neurological Disorders: A Focus on Africa
Neurological disorders related to neuroinfections are highly prevalent in Sub-Saharan Africa (SSA), constituting a major cause of disability and economic …
Article scientifique
Complement System: An Immunotherapy Target in Colorectal Cancer
Colorectal cancer (CRC) is the third most common malignant tumor and the second most fatal cancer worldwide. Several parts of …
Article scientifique
SARS-CoV-2 Variants, Vaccines, and Host Immunity
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new beta coronavirus that emerged at the end of 2019 in …
Article scientifique
Longitudinal Variations of M. tuberculosis-Induced IFN-γ Responses in HIV-Negative Pregnant Women Exposed to Tuberculosis
Introduction Pregnancy triggers an alteration of the immune functions and increases the risk of developing the active tuberculosis (TB) symptoms …
Article scientifique
Deciphering DNA Methylation in HIV Infection
With approximately 38 million people living with HIV/AIDS globally, and a further 1.5 million new global infections per year, it …
Article scientifique
An HIV Vaccine Protective Allele in FCGR2C Associates With Increased Odds of Perinatal HIV Acquisition
In the Thai RV144 HIV-1 vaccine trial, a three-variant haplotype within the Fc gamma receptor 2C gene (FCGR2C) reduced the …
Article scientifique
SARS-CoV-2 and HIV-1: Should HIV-1-Infected Individuals in Sub-Saharan Africa Be Considered a Priority Group for the COVID-19 Vaccines?
Since its emergence in 2019 SARS-CoV-2 has proven to have a higher level of morbidity and mortality compared to the …
Article scientifique
Gamma-Irradiated Fowl Cholera Mucosal Vaccine: Potential Vaccine Candidate for Safe and Effective Immunization of Chicken Against Fowl Cholera
Fowl cholera (FC) caused by Pasteurella multocida is among the serious infectious diseases of poultry. Currently, formalin inactivated FC (FI-FC) …
Article scientifique
Candidate Biomarkers to Distinguish Spinal Tuberculosis From Mechanical Back Pain in a Tuberculosis Endemic Setting
Background: Spinal tuberculosis (TB) may have a variable, non-specific presentation including back pain with- or without- constitutional symptoms. Further tools …
Article scientifique
Host and Bacterial Iron Homeostasis, an Underexplored Area in Tuberculosis Biomarker Research
Mycobacterium tuberculosis (Mtb) “a human adapted pathogen” has found multiple ways to manipulate the host immune response during infection. The …
Article scientifique
Non-Invasive Antibody Assessment in Saliva to Determine SARS-CoV-2 Exposure in Young Children
Saliva is a body fluid with hitherto unused potential for the assessment of SARS-CoV-2 antibodies. Specific antibodies can indicate a …
Article scientifique
Repertoire of Naturally Acquired Maternal Antibodies Transferred to Infants for Protection Against Shigellosis
Shigella is the second leading cause of diarrheal diseases, accounting for >200,000 infections and >50,000 deaths in children under 5 …
Article scientifique
Non-Coding RNAs in the Etiology and Control of Major and Neglected Human Tropical Diseases
Non-coding RNAs (ncRNAs) including microRNAs (miRs) and long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in …
Article scientifique
Myeloperoxidase and Other Markers of Neutrophil Activation Associate With Malaria and Malaria/HIV Coinfection in the Human Placenta
Introduction: Placental malaria (PM) is characterized by accumulation of inflammatory leukocytes in the placenta, leading to poor pregnancy outcomes. Understanding …
Article scientifique
COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks
The progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be …
Article scientifique
Targeting Molecular Inflammatory Pathways in Granuloma as Host-Directed Therapies for Tuberculosis
Globally, more than 10 million people developed active tuberculosis (TB), with 1.4 million deaths in 2020. In addition, the emergence …
Article scientifique
Highlighting the Relevance of CD8+ T Cells in Filarial Infections
The T cell immune responses in filarial infections are primarily mediated by CD4+ T cells and type 2-associated cytokines. Emerging …
Article scientifique
Antigen Presenting Cells Contribute to Persistent Immune Activation Despite Antiretroviral Therapy Initiation During Hyperacute HIV-1 Infection
Human immunodeficiency virus (HIV)-induced changes in immune cells during the acute phase of infection can cause irreversible immunological damage and …
Article scientifique
HIV Broadly Neutralizing Antibodies Expressed as IgG3 Preserve Neutralization Potency and Show Improved Fc Effector Function
The ability of several broadly neutralizing antibodies (bNAbs) to protect against HIV infection is enhanced through Fc receptor binding. Antibody …