471 publication(s) trouvée(s)
Article scientifique
Reduction of blood C-reactive protein concentration complements the resolution of sputum bacillary load in patients on anti-tuberculosis therapy
Background Tuberculosis (TB) is a difficult-to-treat disease requiring the combination of four antibiotics for a minimum of 6 months. Rapid …
Article scientifique
Ciltacabtagene autoleucel: The second anti-BCMA CAR T-cell therapeutic armamentarium of relapsed or refractory multiple myeloma
Ciltacabtagene autoleucel (also known as cilta-cel) is a chimeric antigen receptor (CAR) T-cell therapy that targets B-cell maturation antigen (BCMA) …
Article scientifique
Safety and immunogenicity of BK-SE36 in a blinded, randomized, controlled, age de-escalating phase Ib clinical trial in Burkinabe children
Background A blood-stage vaccine targeting the erythrocytic-stages of the malaria parasite Plasmodium falciparum could play a role to protect against …
Article scientifique
Recent malaria does not substantially impact COVID-19 antibody response or rates of symptomatic illness in communities with high malaria and COVID-19 transmission in Mali, West Africa
Malaria has been hypothesized as a factor that may have reduced the severity of the COVID-19 pandemic in sub-Saharan Africa. …
Article scientifique
The striking mimics between COVID-19 and malaria: A review
Objectives: COVID-19 is a transmissible illness triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since its onset in late …
Article scientifique
The synovial fluid fibroblast-like synoviocyte: A long-neglected piece in the puzzle of rheumatoid arthritis pathogenesis
Rheumatoid arthritis (RA) is a systemic autoimmune disease during which fibroblast-like synoviocytes (FLS) contribute to both joint inflammation and destruction. …
Article scientifique
Volatile organic compounds: A proinflammatory activator in autoimmune diseases
The etiopathogenesis of inflammatory and autoimmune diseases, including pulmonary disease, atherosclerosis, and rheumatoid arthritis, has been linked to human exposure …
Article scientifique
GMZ2 Vaccine-Induced Antibody Responses, Naturally Acquired Immunity and the Incidence of Malaria in Burkinabe Children
GMZ2 is a malaria vaccine candidate evaluated in a phase 2b multi-centre trial. Here we assessed antibody responses and the …
Article scientifique
Potential Utility of Systemic Plasma Biomarkers for Evaluation of Pediatric Schistosomiasis in Western Kenya
Introduction Current diagnostic tools for schistosomiasis are limited, and new tests are necessary to enhance disease diagnosis and surveillance. Identification …
Article scientifique
Role of Early Life Cytotoxic T Lymphocyte and Natural Killer Cell Immunity in Paediatric HIV Cure/Remission in the Anti-Retroviral Therapy Era
Only three well-characterised cases of functional cure have been described in paediatric HIV infection over the past decade. This underlines …
Article scientifique
The Road to Elimination: Current State of Schistosomiasis Research and Progress Towards the End Game
The new WHO Roadmap for Neglected Tropical Diseases targets the global elimination of schistosomiasis as a public health problem. To …
Article scientifique
Recurrent Severe Subclinical Mastitis and the Risk of HIV Transmission Through Breastfeeding
Subclinical mastitis (SCM) is an important risk factor of postnatal HIV-1 transmission that is still poorly understood. A longitudinal sub-study …
Article scientifique
Post-Infectious Autoimmunity in the Central (CNS) and Peripheral (PNS) Nervous Systems: An African Perspective
The direct impact and sequelae of infections in children and adults result in significant morbidity and mortality especially when they …
Article scientifique
A Neurometabolic Pattern of Elevated Myo-Inositol in Children Who Are HIV-Exposed and Uninfected: A South African Birth Cohort Study
Introduction: Exposure to maternal HIV in pregnancy may be a risk factor for impaired child neurodevelopment during the first years …
Article scientifique
Evidence for an Adult-Like Type 1-Immunity Phenotype of Vδ1, Vδ2 and Vδ3 T Cells in Ghanaian Children With Repeated Exposure to Malaria
Effector capabilities of γδ T cells are evident inPlasmodiuminfection in young and adult individuals, while children are the most vulnerable …
Article scientifique
Neuroimmunology of Common Parasitic Infections in Africa
Parasitic infections of the central nervous system are an important cause of morbidity and mortality in Africa. The neurological, cognitive, …
Article scientifique
Interplay Between the Immune and Endocrine Systems in the Lung: Implications for TB Susceptibility
The role of the endocrine system on the immune response, especially in the lung, remains poorly understood. Hormones play a …
Article scientifique
Emerging Role of Platelet-Endothelium Interactions in the Pathogenesis of Severe SARS-CoV-2 Infection-Associated Myocardial Injury
Cardiovascular dysfunction and disease are common and frequently fatal complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Indeed, …
Article scientifique
Alteration of Endocrine Hormones and Antibody Responses in Different Spectrum of Tuberculosis Disease
Effective control of Mycobacterium tuberculosis ( Mtb ) infection is mediated by multifaceted factors that involve both the endocrine and …
Éditorial
Editorial: Immune-Related Non-Communicable Diseases in Africa
Immune-Related Non-Communicable Diseases in AfricaThe African continent has a long-standing tradition of research in communicable diseases.Indeed, several national, regional, and …