471 publication(s) trouvée(s)
Article scientifique
Assessment of a diverse panel of transmitted/founder HIV-1 infectious molecular clones in a luciferase based CD8 T-cell mediated viral inhibition assay
Introduction: Immunological protection against human immunodeficiency virus-1 (HIV-1) infection is likely to require both humoral and cell-mediated immune responses, the …
Article scientifique
Impact of exposure to malaria and nutritional status on responses to the experimental malaria vaccine ChAd63 MVA ME-TRAP in 5-17 month-old children in Burkina Faso
The experimental malaria vaccine ChAd63 MVA ME-TRAP previously showed protective efficacy against Plasmodium falciparum infection in Phase IIa sporozoite challenge …
Article scientifique
COVID-19 vaccinology landscape in Africa
More than two years after the start of COVID-19 pandemic, Africa still lags behind in terms vaccine distribution. This highlights …
Article scientifique
Care of patients with inborn errors of immunity in thirty J Project countries between 2004 and 2021
Introduction: The J Project (JP) physician education and clinical research collaboration program was started in 2004 and includes by now …
Article scientifique
COVID-19 and monkeypox co-infection: A rapid systematic review
October 2022, we used the search term "("monkeypox virus" OR "MPV" OR "monkey pox" OR "monkeypox") AND ("COVID-19" OR "COVID …
Éditorial
Editorial: Epigenetics of infectious diseases
The role of epigenetics in infectious diseasesHost genetics contribute to variations in the acquisition, disease manifestation, and outcomes of pathogenic …
Article scientifique
Identification of potential candidate vaccines against Mycobacterium ulcerans based on the major facilitator superfamily transporter protein
Buruli ulcer is a neglected tropical disease that is characterized by non-fatal lesion development. The causative agent isMycobacterium ulcerans (M. …
Article scientifique
Platelets’ morphology, metabolic profile, exocytosis, and heterotypic aggregation with leukocytes in relation to severity and mortality of COVID-19-patients
Roles of platelets during infections surpass the classical thrombus function and are now known to modulate innate immune cells. Leukocyte-platelet …
Article scientifique
Comparison of the frequency and phenotypic profile of Mycobacterium tuberculosis-specific CD4 T cells between the site of disease and blood in pericardial tuberculosis
Studies of the immune response at the site of disease in extra-pulmonary tuberculosis (EPTB) disease are scarce. In this study, …
Article scientifique
C-Reactive Protein (CRP): A poor prognostic biomarker in COVID-19
Introduction: The COVID-19 pandemic continues to be rampant with considerable morbidity and mortality worldwide since its emergence in December 2019. …
Article scientifique
CD160 receptor in CLL: Current state and future avenues
CD160 is a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein expressed on cytotoxic natural killer (NK) cells and T-cell subsets. It plays …
Article scientifique
CAR T-cells for colorectal cancer immunotherapy: Ready to go?
Chimeric antigen receptor (CAR) T-cells represent a new genetically engineered cell-based immunotherapy tool against cancer. The use of CAR T-cells …
Article scientifique
Sustaining surveillance as an intervention during the COVID-19 pandemic in Cabo Verde and implications for malaria elimination
Cabo Verde reported the first case of COVID-19 on March 19, 2020. Containment measures were quickly implemented and over 80,000 …
Article scientifique
Advancing mRNA technologies for therapies and vaccines: An African context
Synthetic mRNA technologies represent a versatile platform that can be used to develop advanced drug products. The remarkable speed with …
Article scientifique
Phenotypic characterization of Ghanaian P. falciparum clinical isolates reveals a homogenous parasite population
Background: Erythrocyte invasion by P. falciparum involves functionally overlapping interactions between the parasite's ligands and the erythrocyte surface receptors. While …
Article scientifique
Intracellular survival of Streptococcus pneumoniae in human alveolar macrophages is augmented with HIV infection
People Living with HIV (PLHIV) are at an increased risk of pneumococcal pneumonia than HIV-uninfected adults, but the reasons for …
Article scientifique
Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response to Mycobacterium tuberculosis infection in mice
Lymphoblastic leukemia 1 (Lyl1) is a well-studied transcription factor known to exhibit oncogenic potential in various forms of leukemia with …
Article scientifique
Programmed Cell Death-Ligand-1 expression in Bladder Schistosomal Squamous Cell Carcinoma – There’s room for Immune Checkpoint Blockage?
Schistosoma haematobium, the causative agent of urogenital schistosomiasis, is a carcinogen type 1 since 1994. It is strongly associated with …
Article scientifique
Inborn errors of immunity and related microbiome
Inborn errors of immunity (IEI) are characterized by diverse clinical manifestations that are dominated by atypical, recurrent, chronic, or severe …
Article scientifique
IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohort
Introduction Multisystem inflammatory syndrome in children (MIS-C) is a severe acute inflammatory reaction to SARS-CoV-2 infection in children. There is …