471 publication(s) trouvée(s)
Article scientifique
Antibody Responses to Crude Gametocyte Extract Predict Plasmodium falciparum Gametocyte Carriage in Kenya
Background Malaria caused by Plasmodium falciparum remains a serious global public health challenge especially in Africa. Interventions that aim to …
Article scientifique
The Development, Fine Specificity, and Importance of High-Avidity Antibodies to VAR2CSA in Pregnant Cameroonian Women Living in Yaoundé, an Urban City
Pregnant women infected with Plasmodium falciparum often produce antibodies (Abs) to VAR2CSA, a ligand that binds to placental chondroitin sulfate …
Article scientifique
Differential Elevation of Inflammation and CD4+ T Cell Activation in Kenyan Female Sex Workers and Non-Sex Workers Using Depot-Medroxyprogesterone Acetate
Background Depot Medroxyprogesterone (DMPA) is one of the most widely used contraceptives in Sub-Saharan Africa where HIV incidence is high. …
Article scientifique
The Peripheral Blood Transcriptome Is Correlated With PET Measures of Lung Inflammation During Successful Tuberculosis Treatment
Pulmonary tuberculosis (PTB) is characterized by lung granulomas, inflammation and tissue destruction. Here we used within-subject peripheral blood gene expression …
Article scientifique
Inflammatory Determinants of Differential Tuberculosis Risk in Pre-Adolescent Children and Young Adults
The risk of progression from Mycobacterium tuberculosis ( M.tb) infection to active tuberculosis (TB) disease varies markedly with age. TB …
Article scientifique
Memory B-Cell Responses Against Merozoite Antigens After Acute Plasmodium falciparum Malaria, Assessed Over One Year Using a Novel Multiplexed FluoroSpot Assay
Memory B cells (MBCs) are believed to be important for the maintenance of immunity to malaria, and these cells need …
Article scientifique
The Genetics of Human Schistosomiasis Infection Intensity and Liver Disease: A Review
Schistosomiasis remains the fourth most prevalent parasitic disease affecting over 200 million people worldwide. Control efforts have focussed on the …
Article scientifique
A Plasma 5-Marker Host Biosignature Identifies Tuberculosis in High and Low Endemic Countries
Background: Several host inflammatory markers have been proposed as biomarkers for diagnosis and treatment response in Tuberculosis (TB), but few …
Article scientifique
Validation and Optimization of Host Immunological Bio-Signatures for a Point-of-Care Test for TB Disease
The development of a non-sputum-based, point-of-care diagnostic test for tuberculosis (TB) is a priority in the global effort to combat …
Article scientifique
Relevance of QuantiFERON-TB Gold Plus and Heparin-Binding Hemagglutinin Interferon-γ Release Assays for Monitoring of Pulmonary Tuberculosis Clearance: A Multicentered Study
Background Tuberculosis (TB) is a leading infectious cause of death. To improve treatment efficacy, quicker monitoring methods are needed. The …
Article scientifique
Evaluation of Host Serum Protein Biomarkers of Tuberculosis in sub-Saharan Africa
Accurate and affordable point-of-care diagnostics for tuberculosis (TB) are needed. Host serum protein signatures have been derived for use in …
Article scientifique
Less Severe Cases of COVID-19 in Sub-Saharan Africa: Could Co-infection or a Recent History of Plasmodium falciparum Infection Be Protective?
Sub-Saharan Africa has generally experienced few cases and deaths of coronavirus disease 2019 (COVID-19). In addition to other potential explanations …
Article scientifique
Parallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19
Sepsis is a life-threatening systemic illness attributed to a dysregulated host response to infection. Sepsis is a global burden killing …
Article scientifique
Differential Responsiveness of the Platelet Biomarkers, Systemic CD40 Ligand, CD62P, and Platelet-Derived Growth Factor-BB, to Virally-Suppressive Antiretroviral Therapy
Systemic biomarkers of inflammation, including cytokines and chemokines, are potentially useful in the management of both HIV infection and non-AIDS-defining …
Article scientifique
A Longitudinal Analysis Reveals Early Activation and Late Alterations in B Cells During Primary HIV Infection in Mozambican Adults
Primary HIV infection (PHI) and subsequent chronic infection alter B-cell compartment. However, longitudinal analysis defining the dynamics of B-cell alterations …
Article scientifique
Hemoglobin Genotypes Modulate Inflammatory Response to Plasmodium Infection
In 2018, 228 million cases and 405,000 malaria-associated deaths were reported worldwide with a majority being in Africa. A wide …
Article scientifique
Detection of Citrullinated Fibrin in Plasma Clots of Rheumatoid Arthritis Patients and Its Relation to Altered Structural Clot Properties, Disease-Related Inflammation and Prothrombotic Tendency
Aims The risk of cardiovascular events in patients with Rheumatoid Arthritis (RA) is disproportionately heightened as a result of systemic …
Article scientifique
Arachidonic Acid Is a Safe and Efficacious Schistosomicide, and an Endoschistosomicide in Natural and Experimental Infections, and Cysteine Peptidase Vaccinated Hosts
Blood flukes of the genus Schistosoma are covered by a protective heptalaminated, double lipid bilayer surface membrane. Large amounts of …
Article scientifique
Impact of Helminth Infections on Female Reproductive Health and Associated Diseases
A growing body of knowledge exists on the influence of helminth infections on allergies and unrelated infections in the lung …
Article scientifique
Polymorphisms in Fc Gamma Receptors and Susceptibility to Malaria in an Endemic Population
result in a humoral response that could reduce disease symptoms and prevent the development of clinical malaria. The principal mechanism …