471 publication(s) trouvée(s)
Article scientifique
Serological Protection 5–6 Years Post Vaccination Against Yellow Fever in African Infants Vaccinated in Routine Programmes
Introduction Although effective live attenuated yellow fever (YF) vaccines have been available for over 9 decades sporadic outbreaks continue to …
Article scientifique
Genome-Wide Analysis of the Malaria Parasite Plasmodium falciparum Isolates From Togo Reveals Selective Signals in Immune Selection-Related Antigen Genes
Malaria is a public health concern worldwide and Togo has proven to be no exception. Effective approaches to provide information …
Article scientifique
Immunoglobulin M in Health and Diseases: How Far Have We Come and What Next?
B lymphocytes are important in secreting antibodies that protect against invading pathogens such as viruses, bacteria, parasites, and also in …
Article scientifique
Major Scientific Hurdles in HIV Vaccine Development: Historical Perspective and Future Directions
Following the discovery of HIV as a causative agent of AIDS, the expectation was to rapidly develop a vaccine; but …
Article scientifique
Unbiased Profiling Reveals Compartmentalization of Unconventional T-Cells Within the Intestinal Mucosa Irrespective of HIV Infection
The intestinal mucosa is enriched for unconventional T-cells, including mucosal associated invariant T-cells (MAIT), invariant natural killer T-cells (iNKT) and …
Article scientifique
Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life
Human cytomegalovirus (CMV) is a highly prevalent herpesvirus, particularly in sub-Saharan Africa, where it is endemic from infancy. The T …
Article scientifique
Evolutionary Pattern of Interferon Alpha Genes in Bovidae and Genetic Diversity of IFNAA in the Bovine Genome
Interferons are secretory proteins induced in response to specific extracellular stimuli which stimulate intra- and intercellular networks for regulating innate …
Article scientifique
Monitoring Anti-tuberculosis Treatment Response Using Analysis of Whole Blood Mycobacterium tuberculosis Specific T Cell Activation and Functional Markers
Background Blood-based biomarkers have been proposed as an alternative to current sputum-based treatment monitoring methods in active tuberculosis (ATB). The …
Article scientifique
Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans
MR1-restricted T (MR1T) cells are defined by their recognition of metabolite antigens presented by the monomorphic MHC class 1-related molecule, …
Article scientifique
Platelets and Their Role in the Pathogenesis of Cardiovascular Events in Patients With Community-Acquired Pneumonia
Community-acquired pneumonia (CAP) remains an important cause of morbidity and mortality throughout the world with much recent and ongoing research …
Article scientifique
Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection
Tuberculosis remains a leading cause of death globally despite curative treatment, partly due to the difficulty of identifying patients who …
Article scientifique
Topical Tenofovir Pre-exposure Prophylaxis and Mucosal HIV-Specific Fc-Mediated Antibody Activities in Women
The RV144 HIV-vaccine trial highlighted the importance of envelope-specific non-neutralizing antibody (nNAb) Fc-mediated functions as immune correlates of reduced risk …
Article scientifique
Methylation vs. Protein Inflammatory Biomarkers and Their Associations With Cardiovascular Function
DNA methylation data can be used to estimate proportions of leukocyte subsets retrospectively, when directly measured cell counts are unavailable. …
Article scientifique
Gingipain R1 and Lipopolysaccharide From Porphyromonas gingivalis Have Major Effects on Blood Clot Morphology and Mechanics
Background: Porphyromonas gingivalis and its inflammagens is associated with a number of systemic diseases, such as cardiovascular disease and type …
Article scientifique
An RNA-seq Based Machine Learning Approach Identifies Latent Tuberculosis Patients With an Active Tuberculosis Profile
A better understanding of the response against Tuberculosis (TB) infection is required to accurately identify the individuals with an active …
Article scientifique
The Impact of Malaria Parasites on Dendritic Cell–T Cell Interaction
Malaria is caused by apicomplexan parasites of the genus Plasmodium. While infection continues to pose a risk for the majority …
Article scientifique
Human Milk From Atopic Mothers Has Lower Levels of Short Chain Fatty Acids
Short chain fatty acids (SFCAs) are microbial metabolites produced in the gut upon fermentation of dietary fibre. These metabolites interact …
Article scientifique
Iron Deficiency Anemia at Time of Vaccination Predicts Decreased Vaccine Response and Iron Supplementation at Time of Vaccination Increases Humoral Vaccine Response: A Birth Cohort Study and a Randomized Trial Follow-Up Study in Kenyan Infants
Background: Iron deficiency may impair adaptive immunity and is common among African infants at time of vaccination. Whether iron deficiency …
Article scientifique
Limited Impact of Human Cytomegalovirus Infection in African Infants on Vaccine-Specific Responses Following Diphtheria-Tetanus-Pertussis and Measles Vaccination
Human cytomegalovirus (HCMV) infection has a profound effect on the human immune system, causing massive clonal expansion of CD8, and …
Article scientifique
Nanobodies: Prospects of Expanding the Gamut of Neutralizing Antibodies Against the Novel Coronavirus, SARS-CoV-2
OPINION article Front. Immunol., 23 June 2020Sec. Vaccines and Molecular Therapeutics Volume 11 - 2020 | https://doi.org/10.3389/fimmu.2020.01531