471 publication(s) trouvée(s)
Article scientifique
Molecular signaling in coinfection: how M. tuberculosis and respiratory viruses rewire host immunity and alter TB outcomes
) and respiratory viral infections remain major, intersecting global health challenges, and their co-occurrence imposes a disproportionate burden in high-HIV/high-TB …
Article scientifique
Case Report: A novel homozygous splice-site variant in the C3 gene causing complete complement C3 deficiency in two unrelated Moroccan patients
Complement component 3 (C3) plays a central role in innate immunity as a convergence point of the classical, alternative, and …
Article scientifique
Shared germline-biased plasmablast clonotypes shape early neutralizing antibody responses during acute Chikungunya virus infection
Introduction: Chikungunya virus (CHIKV) infection causes acute febrile illness and severe joint inflammation, with some patients progressing to chronic arthritis. …
Article scientifique
Interleukin-15 correlates with cytotoxic immune networks in cervical tuberculous lymphadenitis
Introduction Cervical tuberculous lymphadenitis (CTL) represents a localized manifestation of Mycobacterium tuberculosis infection in which immune responses are organized within …
Article scientifique
Transplacental transfer of anti-malarial antibodies: a systematic review
Background: Pregnant women and young children bear the highest burden of malaria morbidity/mortality. While transplacental transfer of malaria antibodies protects …
Article scientifique
Cytokine-driven modulation of peripheral immune cell populations in Coronavirus disease 2019 patients
Introduction Coronavirus disease 2019 (COVID-19) is characterized by a spectrum of immune dysfunction, from mild illness to life-threatening hyper-inflammation. However, …
Article scientifique
IgG and IgM responses to PfEMP1 domains associated with semi-immunity to clinical malaria in Burkinabe children under five
Background Malaria remains a major global health burden, with children under five years in sub-Saharan Africa disproportionately affected. While immunity …
Éditorial
Editorial: Combination of photodynamic therapy and immunotherapy to overcome cancer resistance
Cancer resistance to conventional therapies remains one of the major challenges in oncology, often resulting from tumor heterogeneity, immune evasion, …
Article scientifique
Ex vivo cytokine responses and metabolic reprogramming are associated with γδ T cell differentiation in Plasmodium falciparum placental malaria
Background γδ T cells play a key role in modulating immune responses to pregnancy-associated malaria and can enhance vaccine efficacy …
Article scientifique
Reduced COVID-19 severity in Africa: a systematic review of host genetic and immunological responses to SARS-CoV-2 infection
Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had immense global consequences, leading to widespread illness, …
Article scientifique
The role of the microbiome in gynecological cancers: implications for diagnosis and treatment
Gynecological malignancies such as cancer of the cervix, ovary, endometrium, vulva, and vagina pose a severe global health burden. Although …
Article scientifique
Variable progressive behavior of Klebsiella pneumoniae at different sites of infection
Klebsiella pneumoniae has persisted for decades as a major global health threat. Although vaccination is widely recognized as the most …
Article scientifique
Graduate-level medical doctors in Uganda have limited awareness of warning, specific signs, and immunological investigations of primary immunodeficiencies
Background: Primary Immunodeficiencies are inborn errors of immunity (IEIs) characterized by impaired immune function, resulting in recurrent infections, inflammation, autoimmunity, …
Éditorial
Editorial: Challenges and perspectives for improved understanding and management of multifaceted co-infection
Infectious diseases rarely occur in isolation, and co-infections involving multiple pathogens are increasingly recognized as a major challenge for clinicians, …
Article scientifique
Autoimmunity and inborn errors of immunity: a complex coexistence
Inborn errors of immunity (IEI) and autoimmune diseases represent two major consequences of immune system dysregulation. Although recurrent infections are …
Article scientifique
CD39 in the pathogenesis of neuro-Behçet disease: is it an immune regulator marker?
Neuro-Behçet's disease (NBD) is a severe neurological manifestation of Behçet's disease (BD), a multisystemic inflammatory vasculitis affecting multiple organs. NBD …
Article scientifique
Venturing into host-pathogen interaction in Crimean-Congo hemorrhagic fever to highlight terra incognita
Crimean-Congo- Hemorrhagic Fever (CCHF) is the most widespread tick-borne disease in the world with a highly variable case fatality rate. …
Article scientifique
The molecular landscape of peach allergy in Tunisia: new insights
Background: Peach allergy represents a significant clinical problem in Mediterranean populations, yet molecular characterization remains limited in North African countries. …
Article scientifique
Tuberculosis preventive therapy in postpartum women with HIV modifies M. tuberculosis-specific and nonspecific immune responses
Background: Tuberculosis (TB) has significant morbidity in pregnant and postpartum women with HIV (pregnant and PPWWHIV). TB preventive therapy (TPT) …
Article scientifique
Case Report: Overlap syndrome of anti–NMDA receptor encephalitis and MOG-associated disease in a pediatric patient—literature insights
Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) and anti-N-methyl-D- aspartate receptor (NMDAR) encephalitis pediatric cases are especially challenging due to phenotypic …