471 publication(s) trouvée(s)
Article scientifique
B and T cell responses to pre-erythrocytic R21/Matrix-M and blood-stage RH5.1/Matrix-M malaria vaccines in endemic settings
Introduction There is great interest in combining the licensed pre-erythrocytic malaria vaccine R21/Matrix-M® and the blood-stage candidate vaccine RH5.1/Matrix-M® to …
Article scientifique
Cytokine profiles, genetic polymorphisms, and systemic inflammatory markers in type 1 diabetes patients with COVID-19: IL-18 a predictor of disease severity
Background: Patients with Type 1 Diabetes Mellitus (T1DM) are at increased risk for severe COVID-19 due to chronic inflammation, immune …
Article scientifique
Persistent immune dysfunction during suppressive antiretroviral therapy: implications for analytical treatment interruption trials for chronic HIV infections in sub-Saharan Africa
Background: Despite the success of long-term antiretroviral therapy (ART), immune dysfunction-including incomplete T helper cell recovery, immune activation, and inflammation-persists …
Article scientifique
Isolation and characterization of Hofbauer cells from human term placentas
Hofbauer cells (HBCs) are macrophages of fetal origin present in the human placenta that play a key role in maintaining …
Article scientifique
Predictive factors for severity and poor treatment response in children with Evans syndrome: A retrospective cohort study
Evans syndrome (ES) is a rare disorder characterized by autoimmune cytopenias affecting multiple blood cell lineages. In children, management remains …
Article scientifique
Mass drug administration of praziquantel lowers the susceptibility of school-aged children to Schistosoma mansoni in endemic areas
Background Schistosomiasis remains a significant public health challenge in endemic regions, leading to substantial morbidity. While regular mass drug administration …
Article scientifique
A machine learning approach to a nine-SNP immunogenetic score for prognostic stratification in cervical cancer
Background: While human papillomavirus (HPV) is the primary driver of cervical cancer (CC), host immune-related genetic variations are thought to …
Article scientifique
JAK-STAT and IL-17 pathway dysregulation underlies persistent immune dysfunction in ART-experienced people living with HIV in Ghana
Introduction: Chronic immune activation and inflammation are central to HIV pathogenesis and persist despite antiretroviral therapy (ART), contributing to non-AIDS …
Article scientifique
Heme oxygenase-1 and malaria pathogenesis
Malaria is a life-threatening parasitic disease and remains a major cause of morbidity and mortality worldwide. The clinical course of …
Article scientifique
Case Report: IL2RA (CD25) deficiency: first reported cases in Morocco
CD25, the α-chain of the interleukin-2 receptor (IL2RA), is a key component of the IL-2 pathway and is essential for …
Éditorial
Commentary: Increased circulating Th17 cells and altered CD4 T cell maturation and differentiation in active tuberculosis with type 2 diabetes: a pilot study
The co-epidemic of tuberculosis (TB) and type 2 diabetes mellitus (T2DM) remains one of the major barriers to global TB …
Article scientifique
Late progression of pediatric Kikuchi-Fujimoto disease to systemic lupus erythematosus: a case report and review of literature
Background: Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting lymphadenitis predominantly affecting children and young adults, often mimicking lymphoma or tuberculous …
Éditorial
Editorial: Cellular metabolism, the immune system, and oncogenesis: opportunities for drug discovery and development
Nearly a century after Otto Warburg first described a unique phenomenon whereby tumour cells prefer the inefficient glycolytic pathway for …
Article scientifique
Systemic–local immune remodeling in colorectal cancer: CD14+ cell-derived cytokine responsiveness, mucosal immune-cell organization, and exploratory metastasis-associated patterns
Background: Immune regulatory networks contribute to colorectal cancer (CRC) progression, but most clinical studies focus on tissue immune-cell abundance or …
Article scientifique
HIV associated immune aging among people living with HIV: implications for long-term antiretroviral therapy and potential HIV cure interventions in sub-Saharan Africa
Background: Clinical and biological consequences of accelerated immune aging are substantial, with growing evidence of increased risk of non-communicable diseases …
Article scientifique
Leishmania infantum eukaryotic initiation factor 4A modulates in vitro functional activity of human neutrophils
Leishmaniases are a group of neglected tropical diseases caused by Leishmania parasites which virulence mainly relies on its modulation of …
Article scientifique
Harnessing natural feed additives for sustainable production and economics: the role of Thymus vulgaris L. oil as an antimicrobial agent and a growth promoter in improving production and health of broiler chickens
Introduction This study examined the effects of adding thyme oil (TO) to broiler diets on growth performance, intestinal health, immune …
Article scientifique
Coordinated kinetics of humoral, T-cell, and cytokine responses to SARS-COV-2 in West African healthcare workers: a multicenter longitudinal study in university hospitals of Abidjan, Côte d’Ivoire
Background Healthcare workers in resource-limited settings are frequently exposed to SARS-CoV-2, often with incomplete vaccine coverage. Yet, their adaptive immune …
Article scientifique
Transplacental transferred anti-SARS-CoV-2 neutralizing antibodies in unvaccinated pregnant women in Cameroon occurred during the COVID-19 pandemic, but not in the pre-pandemic period
Introduction: Neutralizing antibodies (NAbs) are critical for protection against SARS-CoV-2, but there is limited information on their role in pregnancy, …
Article scientifique
CD137 in tuberculosis: a scoping review of an emerging immune checkpoint at the crossroads of diagnosis, prognosis, and therapy
Introduction: . This scoping review brings together current evidence on the clinical relevance of CD137 in tuberculosis (TB), including its …