471 publication(s) trouvée(s)
Éditorial
Editorial: Community series in: the role of vitamin D as an immunomodulator, volume II
Vitamin D has emerged as a multifaceted molecule, acting not only as a regulator of metabolic and skeletal homeostasis but …
Article scientifique
Effectiveness of “tumor necrosis factor inhibitors” in monogenic hereditary recurrent fevers in children and adolescents: a systematic review
Introduction: This systematic review aims to evaluate the clinical effectiveness of tumor necrosis factor (TNF) inhibitors in treating monogenic hereditary …
Article scientifique
Case Report: A novel CIITA mutation causing MHC class II deficiency: first reported case in Morocco
Major histocompatibility complex class II (MHC II) deficiency (bare lymphocyte syndrome type II) is an autosomal-recessive combined immunodeficiency caused by …
Article scientifique
Dietary polyphenols and human health: sources, biological activities, nutritional and immunological aspects, and bioavailability– a comprehensive review
Dietary polyphenols, particularly flavonoids, have been extensively recognized for their role as a source of bioactive molecules that contribute to …
Article scientifique
The unveiled face of IEI: Children Cancer Hospital—Egypt (CCHE-57357) experience
Background: Inborn errors of immunity (IEI) are a heterogeneous group of different disorders characterized by a defect in the function …
Article scientifique
Uncovering the molecular and immunological defects in multicentric carpotarsal osteolysis syndrome: identification of relevant biomarkers
Multicentric carpotarsal osteolysis (MCTO) is a rare genetic disease characterized by progressive osteolysis, often followed by nephropathy in advanced stages. …
Article scientifique
Micro-geographic variation in antigenic diversity of PfEBA-175 region II in asymptomatic Plasmodium falciparum infections in Tanzania
Background Malaria remains a major public health burden, and the development of effective blood-stage vaccines is complicated by extensive antigenic …
Éditorial
Editorial: Understanding the interplay between tumor immune microenvironment and neoantigens for improved immunotherapy
The rise of cancer immunotherapy has transformed oncology, yet its success remains limited by tumor immune escape, intratumoral heterogeneity, and …
Article scientifique
Sputum host cytokine signatures for diagnosis of TB in children and adults
Background Tuberculosis (TB) still remains the world’s leading infectious disease killer. New screening and diagnostic tests are urgently needed. We …
Article scientifique
The effect of treatment with a non-ionic surfactant vesicular formulation of sodium stibogluconate on host immune responses and serum metabolites in a murine model of Leishmania donovani
Introduction Visceral leishmaniasis (VL), caused by Leishmania donovani, is associated with parasite-induced immunological and physiological changes that ensure the survival …
Article scientifique
Humoral immune response to COVID-19 vaccines in onchocerciasis-infected individuals: a field study from Ghana
Introduction: COVID-19 vaccines are the most successful medical interventions to reduce disease severity and mortality. Various vaccine platforms with unique …
Article scientifique
Neutrophil proteins as potential biomarkers for a sputum-based tuberculosis screening test
Introduction: The development of a rapid and affordable assay to screen participants for Q12 additional testing could streamline TB screening …
Article scientifique
Safety, tolerability, and immunogenicity of INO-4500, a synthetic DNA-based vaccine against Lassa virus, in a phase 1b clinical trial in healthy Ghanaian adults
Background: Lassa fever (LF) is an acute viral hemorrhagic illness endemic to West Africa, with no licensed vaccines or targeted …
Article scientifique
Case Report: Dual molecular diagnosis of gain-of-function STAT1 mutation and regulatory STAT3 variant in a patient with a hyper-IgE-like phenotype
Background The transcription factors signal transducer and activator of transcription 1 and 3 (STAT1 and STAT3) play essential roles in …
Article scientifique
Cancer-derived exosomes: mediators of immune crosstalk and emerging targets for immunotherapy
Exosomes, nanoscale extracellular vesicles secreted by various cell types, play pivotal roles in intercellular communication. In cancer, tumor-derived exosomes-referred to …
Article scientifique
Macrophage migration inhibitory factor (MIF) and the tumor ecosystem: a tale of inflammation, immune escape, and tumor growth
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with a pivotal role in immune regulation, inflammation, and tumorigenesis. Originally …
Article scientifique
Effects of sex but not race and geographic origin on vaccine-induced HIV-specific antibody responses
Background: Sex, race and geographic location may affect vaccine-induced immune responses, yet few preventive HIV vaccine trials have systematically evaluated …
Article scientifique
Immunogenetic investigation of WAS patients revealing impaired IL-6/STAT3 signaling in T cells
gene, which encodes WASp, a key regulator of cytoskeletal remodeling. In addition to microthrombocytopenia, affected individuals often present with recurrent …
Article scientifique
Controlled human malaria infection studies: insights into recent advances and key immunological and ethical implementation lessons
Controlled human infection studies offer a unique opportunity to study the efficacy of novel interventions, mechanisms of infection and disease, …
Article scientifique
Seroprevalence of antibodies to Plasmodium falciparum transmission-blocking target proteins Pfs230D1M and Pfs48/45 in Tanzanian populations of diverse malaria transmission intensity
Transmission-blocking vaccines are among the novel tools under development for malaria control and elimination. Understanding the human immune response to …