471 publication(s) trouvée(s)
Article scientifique
Mesenchymal stem cells enhanced with SeNPs protection against CLP induction associated with liver injury are mediated via antioxidant, anti-inflammatory, and immunomodulatory activities
Introduction: Sepsis-induced liver injury is a serious issue in critical care. Since antibiotics are insufficiently effective to combat the disease …
Article scientifique
High prevalence of the hotspot complement factor I p.Ile357Met pathogenic variant in Tunisian atypical hemolytic uremic syndrome patients: report of three new cases and review of the literature
Introduction Atypical Hemolytic Uremic Syndrome (aHUS) is the prototype of renal diseases secondary to dysregulation of the alternative complement pathway. …
Article scientifique
Prevalence and clinical implications of major and minor ANCAs in Tunisian (North African) patients with systemic lupus erythematosus
Introduction: Anti-neutrophil cytoplasmic antibodies (ANCAs) have been reported in systemic lupus erythematosus (SLE). Their clinical significance remains unclear especially in …
Article scientifique
Vibrio cholerae-specific antibodies in plasma and saliva in cholera patients during a severe outbreak in Zambia: an antibody profiling approach
Background Cholera is a public health threat in resource-limited settings and is responsible for causing over 3 million cases globally. …
Article scientifique
Urticarial hypocomplementemic vasculitis syndrome and systemic lupus erythematosus: a case report and review of the literature
Background: Hypocomplementemic urticarial vasculitis (HUV) syndrome is a rare form of small-vessel vasculitis characterized by a heterogeneous spectrum of clinical …
Article scientifique
HIV cure research contributions from Africa in the last three decades
Introduction: The HIV epidemic in Africa is characterized by extensive viral subtype diversity and human genetic heterogeneity which influence disease …
Article scientifique
Dietary lysophospholipids enhance broiler performance, immune response, meat quality, and mitigate oxidative stress
Background The current study evaluated the impact of lysophospholipid emulsifiers’ (LPLs) dietary incorporation on ameliorating the negative impacts of oxidative …
Article scientifique
Innate immune dysfunction and persistent activation in South African HIV elite controllers
Background Elite controllers can spontaneously control HIV-1 infection without antiretroviral treatment but remain at risk of developing non-AIDS-related conditions. The …
Article scientifique
Curcumin, an active component of turmeric: biological activities, nutritional aspects, immunological, bioavailability, and human health benefits - a comprehensive review
therapeutic effects through multiple pathways. Extensive studies on its pharmacological properties have shown its anti-inflammatory, antioxidant, antinociceptive, antimicrobial, antiparasitic, antimalarial, …
Article scientifique
Development of high affinity antibodies to Plasmodium falciparum merozoite and sporozoite antigens during infancy and adulthood
Antibodies are important for protection against malaria. For optimal protective activity, it is thought that antibodies need to have high …
Article scientifique
Exploring the P. falciparum antigens associated with reduced risk of malaria in pregnancy
Plasmodium falciparum infection in pregnancy leads to substantial maternal and infant morbidity and mortality. Such an infection may result in …
Article scientifique
Vaginal microbiome dysbiosis and sexually transmitted infections correlate with concentrations of immunoglobulin isotypes in human cervicovaginal mucus: insights into HIV-1 transmission
Introduction Little is known about the relationship between antibody isotype in cervicovaginal mucus (CVM) and the local microenvironment and how …
Article scientifique
Cytokines unveiled: their impact on oral and multisystem features of lupus erythematosus
Systemic Lupus Erythematosus (SLE) is a multifaceted autoimmune disorder characterized by widespread inflammation and immune dysregulation, impacting various organ systems …
Article scientifique
Immunomodulatory effects of atorvastatin on peripheral blood mononuclear cells infected with Mycobacterium tuberculosis
Background Tuberculosis (TB) remains a major global health threat, contributing substantially to high morbidity and mortality rates. This underscores the …
Article scientifique
Clinical, immunological, and genetic landscape of common variable immunodeficiency in Morocco: a nationwide multicenter study
Background Common Variable Immunodeficiency (CVID) is the most prevalent symptomatic inborn errors of immunity (IEI), characterized by impaired antibody production, …
Article scientifique
Clinical and biochemical characterization of hepatitis B surface antigen-positive patients with or without Helicobacter pylori co-infection at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
Background Hepatitis B virus (HBV) is a major global public health issue and the most common etiology of chronic liver …
Article scientifique
Antiretroviral therapy initiated during acute infection in women with HIV-1 clade C reduces anti-Tat antibody production and lowers CD8+ T cell activation
Introduction: The HIV-1 Tat protein is essential for virus replication and spread and is therefore a potential target for anti-HIV …
Article scientifique
Performance of eight serum cytokine/chemokine biomarkers in discriminating between active and latent tuberculosis infection in Ghana
Introduction: The existing Interferon γ release assay (IGRA) tests for TB infection, lacks utility in discriminating between active TB (ATB) …
Article scientifique
Vaccine-induced responses to R21/Matrix-M – an analysis of samples from a phase 1b age de-escalation, dose-escalation trial
Introduction The pre-erythrocytic malaria vaccine R21 vaccine adjuvanted with Matrix-M reported good efficacy (75%) in an ongoing phase 3 trial …
Article scientifique
Immune responses to human papillomavirus infection and vaccination
Human papillomavirus (HPV) is the most common sexually transmitted infection. About 90% of HPV infections are transient, resolving without any …