471 publication(s) trouvée(s)
Article scientifique
Plasma IL-5 but Not CXCL13 Correlates With Neutralization Breadth in HIV-Infected Children
Children may be the optimal target for HIV vaccine development as they generate substantially more frequent and more potent broadly …
Article scientifique
Phenotypic Evidence of T Cell Exhaustion and Senescence During Symptomatic Plasmodium falciparum Malaria
infections. Their regulation of the immune response in symptomatic children with malaria has been deemed necessary to prevent immune associated …
Article scientifique
DNA Vaccines Against Mycoplasma Elicit Humoral Immune Responses in Ostriches
In ostriches, the population densities resulting from intensive rearing increases susceptibility to pathogens such as mycoplasmas. In addition to good …
Article scientifique
Chronic HIV-1 Infection Alters the Cellular Distribution of FcγRIIIa and the Functional Consequence of the FcγRIIIa-F158V Variant
Chronic HIV-infection modulates the expression of Fc gamma receptors (FcγRs) on immune cells and their antibody-dependent effector function capability. Given …
Article scientifique
The Emerging Role of Myeloid-Derived Suppressor Cells in Tuberculosis
) infection, however the adverse role of specific myeloid subsets has increasingly been appreciated. The relevance of such cells in …
Article scientifique
HIV-Exposed Uninfected Infants Have Increased Regulatory T Cells That Correlate With Decreased T Cell Function
Background HIV-exposed uninfected infants (HEU) are at higher risk of severe infections, hospitalizations and death compared with HIV-unexposed uninfected infants …
Article scientifique
TLR10 Senses HIV-1 Proteins and Significantly Enhances HIV-1 Infection
Toll-like receptors (TLRs) play a crucial role in innate immunity and provide a first line of host defense against invading …
Article scientifique
Human Vδ1+ T Cells in the Immune Response to Plasmodium falciparum Infection
Naturally acquired protective immunity to Plasmodium falciparum malaria is mainly antibody-mediated. However, other cells of the innate and adaptive immune …
Article scientifique
Reversal of New Onset Type 1 Diabetes by Oral Salmonella-Based Combination Therapy and Mediated by Regulatory T-Cells in NOD Mice
Autoimmune diseases such as type 1 diabetes (T1D) involve the loss of regulatory mechanisms resulting in increased tissue-specific cytotoxicity. The …
Article scientifique
Semen IgM, IgG1, and IgG3 Differentially Associate With Pro-Inflammatory Cytokines in HIV-Infected Men
Genital inflammation significantly increases the risk for HIV infection. The seminal environment is enriched in pro-inflammatory cytokines and chemokines. Here, …
Article scientifique
Low Levels of Human Antibodies to Gametocyte-Infected Erythrocytes Contrasts the PfEMP1-Dominant Response to Asexual Stages in P. falciparum Malaria
Vaccines that target Plasmodium falciparum gametocytes have the potential to reduce malaria transmission and are thus attractive targets for malaria …
Article scientifique
Changes in Mycobacterium tuberculosis-Specific Immunity With Influenza co-infection at Time of TB Diagnosis
Background: Prior Influenza A viral (IAV) infection has been shown to increase susceptibility to tuberculosis (TB) and TB has also …
Article scientifique
Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG
-infected erythrocytes (IEs), where they contribute to the pathogenesis of malaria and are important targets of acquired immunity. Although the …
Article scientifique
The lncRNA Connection Between Cellular Metabolism and Epigenetics in Trained Immunity
Trained immunity describes the ability of innate immune cells to form immunological memories of prior encounters with pathogens. Recollection of …
Article scientifique
Type 3 ILCs in Lung Disease
The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from …
Article scientifique
Inflammatory Cytokine Profiles of Semen Influence Cytokine Responses of Cervicovaginal Epithelial Cells
Genital inflammatory cytokine responses increase HIV risk. Since male partner semen is a complex mixture of immune-modulatory prostaglandins and cytokines, …
Article scientifique
Human Hookworm Infection Enhances Mycobacterial Growth Inhibition and Associates With Reduced Risk of Tuberculosis Infection
Soil-transmitted helminths and Mycobacterium tuberculosis frequently coincide geographically and it is hypothesized that gastrointestinal helminth infection may exacerbate tuberculosis (TB) …
Article scientifique
Major TCR Repertoire Perturbation by Immunodominant HLA-B*44:03-Restricted CMV-Specific T Cells
Lack of disease during chronic human cytomegalovirus (CMV) infection depends on the maintenance of a high-frequency CMV-specific T cell response. …
Article scientifique
Refining Diagnosis of Schistosoma haematobium Infections: Antigen and Antibody Detection in Urine
Background: Traditional microscopic examination of urine or stool for schistosome eggs lacks sensitivity compared to measurement of schistosome worm-derived circulating …
Article scientifique
Host Regulators of Liver Fibrosis During Human Schistosomiasis
Liver fibrosis is a wound-healing process purposely aimed at restoring organ integrity after severe injury caused by autoimmune reactions, mechanical …