471 publication(s) trouvée(s)
Article scientifique
Frequency of Circulating CD4+Ki67+HLA-DR− T Regulatory Cells Prior to Treatment for Multidrug Resistant Tuberculosis Can Differentiate the Severity of Disease and Predict Time to Culture Conversion
Identifying a blood circulating cellular biomarker that can be used to assess severity of disease and predict the time to …
Article scientifique
Schistosomiasis Burden and Its Association With Lower Measles Vaccine Responses in School Children From Rural Cameroon
Background and Methods: Schistosomiasis is debilitating and reported to impair immune responsiveness of infected hosts. In Cameroon, mass drug administration …
Article scientifique
Complement Component C1q as Serum Biomarker to Detect Active Tuberculosis
Background: Tuberculosis (TB) remains a major threat to global health. Currently, diagnosis of active TB is hampered by the lack …
Article scientifique
HIV-1 Viral Loads Are Not Elevated in Individuals Co-infected With Schistosoma spp. After Adjustment for Duration of HIV-1 Infection
Studies of the role of Schistosoma co-infections on plasma HIV-1 RNA (HIV-1 viral load) have yielded incongruent results. The role …
Article scientifique
Variation in the Untranslated Genome and Susceptibility to Infections
The clinical outcomes of infections are highly variable among individuals and are determined by complex host-pathogen interactions. Genome-wide association studies …
Article scientifique
Chickens Expressing IFIT5 Ameliorate Clinical Outcome and Pathology of Highly Pathogenic Avian Influenza and Velogenic Newcastle Disease Viruses
Innate antiviral immunity establishes first line of defence against invading pathogens through sensing their molecular structures such as viral RNA. …
Article scientifique
IL-22: An Underestimated Player in Natural Resistance to Tuberculosis?
(Mtb) develop active tuberculosis (TB) during their lifetime. Although it is well recognized that T-helper 1 immune responses are crucial …
Article scientifique
Phenotypic Changes on Mycobacterium Tuberculosis-Specific CD4 T Cells as Surrogate Markers for Tuberculosis Treatment Efficacy
Background: The analysis of phenotypic characteristics on Mycobacterium tuberculosis (MTB)-specific T cells is a promising approach for the diagnosis of …
Article scientifique
The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris—Analysis of Four Different Ethnic Cohorts
IgG3 is the IgG subclass with the strongest effector functions among all four IgG subclasses and the highest degree of …
Article scientifique
Epigenetics and Malaria Susceptibility/Protection: A Missing Piece of the Puzzle
A better understanding of stable changes in regulation of gene expression that result from epigenetic events is of great relevance …
Article scientifique
Susceptibility to Tuberculosis Is Associated With PI3K-Dependent Increased Mobilization of Neutrophils
Neutrophilia is a condition commonly observed in patients with late-stage tuberculosis, but evidence suggests that increased neutrophil influx begins early …
Article scientifique
Elevated IgG Responses in Infants Are Associated With Reduced Prevalence of Mycobacterium tuberculosis Infection
Background: It is unclear whether antibodies can prevent Mycobacterium tuberculosis (Mtb) infection. In this study, we examined the relationship between …
Article scientifique
Intravascular Schistosoma mansoni Cleave the Host Immune and Hemostatic Signaling Molecule Sphingosine-1-Phosphate via Tegumental Alkaline Phosphatase
Schistosomes are intravascular parasitic platyhelminths that infect >200 million people globally. These long-lived parasites do not appear to provoke thrombus …
Article scientifique
Prostaglandin E2 Stimulates the Expansion of Regulatory Hematopoietic Stem and Progenitor Cells in Type 1 Diabetes
Hematopoietic stem and progenitor cells (HSPCs) are multipotent stem cells that have been harnessed as a curative therapy for patients …
Article scientifique
Trans-Allelic Model for Prediction of Peptide:MHC-II Interactions
Major histocompatibility complex class two {(MHC-II)} molecules are trans-membrane proteins and key components of the cellular immune system. Upon recognition …
Article scientifique
Impact of Mothers’ Schistosomiasis Status During Gestation on Children’s IgG Antibody Responses to Routine Vaccines 2 Years Later and Anti-Schistosome and Anti-Malarial Responses by Neonates in Western Kenya
The potential consequences of parasitic infections on a person’s immune responsiveness to unrelated antigens are often conjectured upon in relationship …
Article scientifique
Herd Immunity to Ebolaviruses Is Not a Realistic Target for Current Vaccination Strategies
The recent West African Ebola virus pandemic, which affected >28,000 individuals increased interest in anti-Ebolavirus vaccination programs. Here, we systematically …
Article scientifique
Origin and Evolution of Dendritic Epidermal T Cells
Dendritic epidermal T cells (DETCs) expressing invariant Vγ5Vδ1 T-cell receptors play a crucial role in maintaining skin homeostasis in mice. …
Article scientifique
The Role of Optineurin in Antiviral Type I Interferon Production
After a viral infection and the stimulation of some pattern-recognition receptors as the toll-like receptor 3 in the endosomes or …
Article scientifique
A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts
(MTB)-exposed individuals will progress to active tuberculosis are urgently needed. Intracellular microRNAs (miRNAs) regulate the host response to MTB and …