471 publication(s) trouvée(s)
Article scientifique
Differential Effect of Viable Versus Necrotic Neutrophils on Mycobacterium tuberculosis Growth and Cytokine Induction in Whole Blood
Neutrophils exert both positive and negative influences on the host response to tuberculosis, but the mechanisms by which these differential …
Article scientifique
Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma
Immune checkpoint inhibitors (ICI) have revolutionized the treatment of advanced melanoma. The first ICI to demonstrate clinical benefit, ipilimumab, targets …
Article scientifique
Altered Toll-Like Receptor-4 Response to Lipopolysaccharides in Infants Exposed to HIV-1 and Its Preventive Therapy
Pathogen sensing and recognition through pattern recognition receptors, and subsequent production of proinflammatory cytokines, is the cornerstone of the innate …
Article scientifique
Humoral Responses Elicited by Adenovirus Displaying Epitopes Are Induced Independently of the Infection Process and Shaped by the Toll-Like Receptor/MyD88 Pathway
The use of serotype 5 adenovirus (Ad)-derived vectors in vaccination is confronted to preexisting anti-Ad immunity. Epitope display on Ad …
Article scientifique
Histopathological Correlations between Mediastinal Fat-Associated Lymphoid Clusters and the Development of Lung Inflammation and Fibrosis following Bleomycin Administration in Mice
Bleomycin (BLM) has been reported to induce lung inflammation and fibrosis in human and mice and showed genetic susceptibility. Interestingly, …
Article scientifique
Dectin-1-Syk-CARD9 Signaling Pathway in TB Immunity
(Mtb) is recognition of the pathogen through pattern-recognition receptors (PRRs) expressed by innate immune cells. Activation of the PRR Dectin-1 …
Article scientifique
B and T Cell Phenotypic Profiles of African HIV-Infected and HIV-Exposed Uninfected Infants: Associations with Antibody Responses to the Pentavalent Rotavirus Vaccine
We examined associations between B and T cell phenotypic profiles and antibody responses to the pentavalent rotavirus vaccine (RV5) in …
Article scientifique
Detection of Pathogen Exposure in African Buffalo Using Non-Specific Markers of Inflammation
Detecting exposure to new or emerging pathogens is a critical challenge to protecting human, domestic animal and wildlife health. Yet …
Article scientifique
T Cell Activation in South African HIV-Exposed Infants Correlates with Ochratoxin A Exposure
The introduction of non-breastmilk foods to HIV-infected infants is associated with increased levels of immune activation, which can impact the …
Article scientifique
The Kinetics of the Humoral and Interferon-Gamma Immune Responses to Experimental Mycobacterium bovis Infection in the White Rhinoceros (Ceratotherium simum)
Mycobacterium bovis is the cause of tuberculosis (TB) in a wide range of species, including white rhinoceroses (Ceratotherium simum). Control …
Article scientifique
MicroRNA miR-214 Inhibits Snakehead Vesiculovirus Replication by Promoting IFN-α Expression via Targeting Host Adenosine 5′-Monophosphate-Activated Protein Kinase
Background: Snakehead vesiculovirus (SHVV), a new rhabdovirus isolated from diseased hybrid snakehead, has emerged as an important pathogen during the …
Article scientifique
A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine against Shigella sonnei Administered Intramuscularly to Adults from a Shigellosis-Endemic Country
Shigellosis is a mild-to-severe diarrheal infection caused by the genus Shigella and responsible for significant morbidity and mortality worldwide. We …
Article scientifique
Tumor Necrosis Factor-Alpha Targeting Can Protect against Arthritis with Low Sensitization to Infection
Tumor necrosis factor-alpha (TNF-alpha) blockade is an effective treatment for rheumatoid arthritis (RA) and other inflammatory diseases, but in patients, …
Article scientifique
Exome Sequencing Identifies a Novel MAP3K14 Mutation in Recessive Atypical Combined Immunodeficiency
Primary immunodeficiency disorders (PIDs) render patients vulnerable to infection with a wide range of microorganisms, and thus provide good in …
Article scientifique
Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review
Ramadan is the ninth month of the Islamic lunar calendar and is observed by Muslims as a month of fasting. …
Article scientifique
IL-4Rα Signaling in Keratinocytes and Early IL-4 Production Are Dispensable for Generating a Curative T Helper 1 Response in Leishmania major-Infected C57BL/6 Mice
Experimental infection with the protozoan parasite Leishmania major has been extensively used to understand the mechanisms involved in T helper …
Article scientifique
Assessment of the Combined Effect of Epstein–Barr Virus and Plasmodium falciparum Infections on Endemic Burkitt Lymphoma Using a Multiplex Serological Approach
Epstein-Barr virus (EBV) is a necessary cause of endemic Burkitt lymphoma (eBL), while the role of Plasmodium falciparum in eBL …
Article scientifique
SIgA, TGF-β1, IL-10, and TNFα in Colostrum Are Associated with Infant Group B Streptococcus Colonization
BACKGROUND: infected breastmilk. Although maternal/infant colonization with GBS is common, the majority of infants exposed to GBS remain unaffected. The …
Article scientifique
IL-36α Regulates Tubulointerstitial Inflammation in the Mouse Kidney
IL-36α, a member of the IL-1 family, is a crucial mediator of inflammatory responses. We previously found that IL-36α was …
Article scientifique
IL-17 Production from T Helper 17, Mucosal-Associated Invariant T, and γδ Cells in Tuberculosis Infection and Disease
IL-17 producing cells have been shown to be important in the early stages of Mycobacterium tuberculosis (Mtb) infection in animal …