471 publication(s) trouvée(s)
Article scientifique
Ensuring Access to Immunoglobulin Therapies for People with Primary Immunodeficiency: A Need to Improve Individuals’ Quality of Life and the Sustainability of Health-care Systems
OPINION article Front. Immunol., 19 September 2017Sec. Primary Immunodeficiencies Volume 8 - 2017 | https://doi.org/10.3389/fimmu.2017.01165
Article scientifique
Cellular Architecture of Spinal Granulomas and the Immunological Response in Tuberculosis Patients Coinfected with HIV
Mycobacterium tuberculosis (M.tb) and HIV are individually responsible for the most deaths worldwide among all infectious agents, and co-infection with …
Article scientifique
Functional Analysis of Phagocyte Activity in Whole Blood from HIV/Tuberculosis-Infected Individuals Using a Novel Flow Cytometry-Based Assay
analysis is paramount to our understanding of those immune mechanisms that lead to protection or susceptibility against a broad range …
Article scientifique
New Insight into the Pathogenesis of Erythema Nodosum Leprosum: The Role of Activated Memory T-Cells
Memory T-cells, particularly, effector memory T cells are implicated in the pathogenesis of inflammatory diseases and may contribute to tissue …
Article scientifique
Thymic Output and CD4 T-Cell Reconstitution in HIV-Infected Children on Early and Interrupted Antiretroviral Treatment: Evidence from the Children with HIV Early Antiretroviral Therapy Trial
OBJECTIVES: Early treatment of HIV-infected children and adults is important for optimal immune reconstitution. Infants' immune systems are more plastic …
Article scientifique
The Recombinant Bacille Calmette–Guérin Vaccine VPM1002: Ready for Clinical Efficacy Testing
The only licensed vaccine against tuberculosis (TB), Bacille Calmette-Guérin (BCG), protects against severe extra pulmonary forms of TB but is …
Article scientifique
Negative Correlation between Circulating CD4+FOXP3+CD127− Regulatory T Cells and Subsequent Antibody Responses to Infant Measles Vaccine but Not Diphtheria–Tetanus–Pertussis Vaccine Implies a Regulatory Role
Regulatory T cells (Tregs) play a key homeostatic role by suppressing immune responses. They have been targeted in mouse and …
Article scientifique
Clinical Efficacy, Safety, and Immunogenicity of a Live Attenuated Tetravalent Dengue Vaccine (CYD-TDV) in Children: A Systematic Review with Meta-analysis
Background: Dengue haemorrhagic fever is the leading cause of hospitalisation and death in children living in Asia and Latin America. …
Article scientifique
The Activity of the Neutral Sphingomyelinase Is Important in T Cell Recruitment and Directional Migration
Breakdown of sphingomyelin as catalysed by the activity of sphingomyelinases profoundly affects biophysical properties of cellular membranes which is particularly …
Article scientifique
RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T Cell Responses in a Pediatric African Phase III Trial
Comprehensive assessment of cellular responses to the RTS,S/AS01E vaccine is needed to understand potential correlates and ultimately mechanisms of protection …
Article scientifique
Analysis of the Phenotype of Mycobacterium tuberculosis-Specific CD4+ T Cells to Discriminate Latent from Active Tuberculosis in HIV-Uninfected and HIV-Infected Individuals
Several immune-based assays have been suggested to differentiate latent from active tuberculosis. However, their relative performance as well as their …
Article scientifique
Transcriptional Profiling of Midguts Prepared from Trypanosoma/T. congolense-Positive Glossina palpalis palpalis Collected from Two Distinct Cameroonian Foci: Coordinated Signatures of the Midguts’ Remodeling As T. congolense-Supportive Niches
Our previous transcriptomic analysis of Glossina palpalis gambiensis experimentally infected or not with Trypanosoma brucei gambiense aimed to detect differentially …
Article scientifique
Family History of Early Infant Death Correlates with Earlier Age at Diagnosis But Not Shorter Time to Diagnosis for Severe Combined Immunodeficiency
Background Severe combined immunodeficiency (SCID) is fatal unless treated with hematopoietic stem cell transplant. Delay in diagnosis is common without …
Article scientifique
Sequence-Based Genotyping of Expressed Swine Leukocyte Antigen Class I Alleles by Next-Generation Sequencing Reveal Novel Swine Leukocyte Antigen Class I Haplotypes and Alleles in Belgian, Danish, and Kenyan Fattening Pigs and Göttingen Minipigs
The need for typing of the swine leukocyte antigen (SLA) is increasing with the expanded use of pigs as models …
Article scientifique
Changes in Host Immune–Endocrine Relationships during Tuberculosis Treatment in Patients with Cured and Failed Treatment Outcomes
A bidirectional communication between the immune and endocrine systems exists and facilitates optimum responses in the host during infections. This …
Article scientifique
Lessons from Genetic Studies of Primary Immunodeficiencies in a Highly Consanguineous Population
During the last decades, the study of primary immunodeficiencies (PIDs) has contributed tremendously to unravel novel pathways involved in a …
Article scientifique
Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication
Immunodeficiency-associated vaccine-derived polioviruses (iVDPVs) have been isolated from primary immunodeficiency (PID) patients exposed to oral poliovirus vaccine (OPV). Patients may …
Article scientifique
Non-Steroidal Anti-inflammatory Drugs As Host-Directed Therapy for Tuberculosis: A Systematic Review
Lengthy, antimicrobial therapy targeting the pathogen is the mainstay of conventional tuberculosis treatment, complicated by emerging drug resistances. Host-directed therapies, …
Article scientifique
What’s Normal? Immune Profiling of Human Milk from Healthy Women Living in Different Geographical and Socioeconomic Settings
Human milk provides a very wide range of nutrients and bioactive components, including immune factors, human milk oligosaccharides, and a …
Article scientifique
Myristoylation: An Important Protein Modification in the Immune Response
Protein N-myristoylation is a cotranslational lipidic modification specific to the alpha-amino group of an N-terminal glycine residue of many eukaryotic …