Frontiers in Immunology

ISSN : 1664-3224
471 publication(s) trouvée(s)
Article scientifique
High Sporozoite Antibody Titers in Conjunction with Microscopically Detectable Blood Infection Display Signatures of Protection from Clinical Malaria
Immuno-epidemiological studies typically reveal slow, age-dependent acquisition of immune responses against Plasmodium falciparum sporozoites. Naturally acquired immunity against pre-erythrocytic stages …
2017 Open Access
Article scientifique
Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes
The antioxidant enzyme heme oxygenase-1 (HO-1) is implicated in the pathogenesis of tuberculosis (TB) and has been proposed as a …
2017 Open Access
Article scientifique
Regulatory T Cells and Pro-inflammatory Responses Predominate in Children with Tuberculosis
Background: Following infection with Mycobacterium tuberculosis (M.tb), children are more susceptible to develop disease, particularly extra-pulmonary disease, than adults. The …
2017 Open Access
Article scientifique
Cases of Impaired Oxidative Burst in HIV-Exposed Uninfected Infants’ Neutrophils—A Pilot Study
An increased risk of serious bacterial infections in HIV-exposed uninfected (HEU) infants has been demonstrated. Although neutrophils are essential for …
2017 Open Access
Article scientifique
The Function of FK506-Binding Protein 13 in Protein Quality Control Protects Plasma Cells from Endoplasmic Reticulum Stress-Associated Apoptosis
Plasma cells (PCs) are exposed to intense endoplasmic reticulum (ER) stress imposed by enormous rates of immunoglobulin (Ig) synthesis and …
2017 Open Access
Article scientifique
Monomeric Immunoglobulin A from Plasma Inhibits Human Th17 Responses In Vitro Independent of FcαRI and DC-SIGN
Circulating immunoglobulins including IgG and IgM play a critical role in the immune homeostasis by modulating functions of immune cells. …
2017 Open Access
Article scientifique
Impact of Metabolism in on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment
The immune system and metabolism are highly integrated and multilevel interactions between metabolic system and T lymphocyte signaling and fate …
2017 Open Access
Article scientifique
Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis
Tuberculosis of the central nervous system (CNS-TB) is a devastating complication of tuberculosis, and tumour necrosis factor (TNF) is crucial …
2017 Open Access
Article scientifique
Macrophages Polarized by Expression of ToxoGRA15II Inhibit Growth of Hepatic Carcinoma
A growing body of evidence suggests that tumor associated macrophages (TAMs) are deeply involved in the hepatocellular carcinoma (HCC) proliferation, …
2017 Open Access
Article scientifique
Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model
Although a correlation between polymorphisms of NOD-like receptor family-pyrin domain containing 3 (NLRP3) and predisposition to type 1 diabetes (T1D) …
2017 Open Access
Article scientifique
CD28− and CD28lowCD8+ Regulatory T Cells: Of Mice and Men
Since the rebirth of regulatory (formerly known as suppressor) T cells in the early 90's, research in the field of …
2017 Open Access