46 publication(s) trouvée(s)
Article scientifique
The Ifng antisense RNA 1 (IFNG-AS1) and growth arrest-specific transcript 5 (GAS5) are novel diagnostic and prognostic markers involved in childhood ITP
Background/aim:IFNG-AS1 is a long noncoding RNA that works as an enhancer for the Interferon-gamma (IFN-γ) transcript. GAS5 (growth arrest-specific 5) …
Article scientifique
Gasdermin D: A potential mediator and prognostic marker of bladder cancer
Background: Bladder cancer is considered one of the commonest widespread cancers, its presentation ranges from non-muscle invasive form to being …
Article scientifique
Long non-coding RNA NBAT1, TUG1, miRNA-335, and miRNA-21 as potential biomarkers for acute ischemic stroke and their possible correlation to thyroid hormones
Objective: RNA-based mechanisms of epigenetic modification related to acute ischemic stroke (AIS) have been widely studied recently. The current work …
Article scientifique
Inhibition of Plasmodium falciparum Hsp70-Hop partnership by 2-phenylthynesulfonamide
Plasmodium falciparum Hsp70-1 (PfHsp70-1; PF3D7_0818900) and PfHsp90 (PF3D7_0708400) are essential cytosol localized chaperones of the malaria parasite. The two chaperones …
Article scientifique
RNA interference (RNAi) applications to the management of fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae): Its current trends and future prospects
The fall armyworm Spodoptera frugiperda (Lepidoptera: Noctuidae) is among the invasive insect pests that damages maize and sorghum, the high-priority …
Article scientifique
Endogenous advanced glycation end products in the pathogenesis of chronic diabetic complications
Diabetes is a common metabolic illness characterized by hyperglycemia and is linked to long-term vascular problems that can impair the …
Article scientifique
Host cell stress response as a predictor of COVID-19 infectivity and disease progression
The coronavirus disease (COVID-19) caused by a coronavirus identified in December 2019 has caused a global pandemic. COVID-19 was declared …
Article scientifique
Influence of seasonal and geographic variation on the anti-HSV-1 properties and chlorogenic acids content of Helichrysum aureonitens Sch. Bip
Pharmacological studies conducted in the past revealed the potential source of medicinal plants in the development of novel medicines. The …
Article scientifique
Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?
Plasmodium falciparum is responsible for the most severe and deadliest human malaria infection. The most serious complication of this infection …
Article scientifique
Implication of miR-122, miR-483, and miR-335 Expression Levels as Potential Signatures in HCV-Related Hepatocellular Carcinoma (HCC) in Egyptian Patients
Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related deaths worldwide with chronic hepatitis C virus (HCV) infection …
Article scientifique
Identifying SARS-CoV-2 Lineage Mutation Hallmarks and Correlating Them With Clinical Outcomes in Egypt: A Pilot Study
The SARS-CoV-2 pandemic has led to over 4.9 million deaths as of October 2021. One of the main challenges of …
Article scientifique
Differential Expression of Serum TUG1, LINC00657, miR-9, and miR-106a in Diabetic Patients With and Without Ischemic Stroke
Background: Ischemic stroke is one of the serious complications of diabetes. Non-coding RNAs are established as promising biomarkers for diabetes …
Article scientifique
SARS-CoV-2 Spike Protein Unlikely to Bind to Integrins via the Arg-Gly-Asp (RGD) Motif of the Receptor Binding Domain: Evidence From Structural Analysis and Microscale Accelerated Molecular Dynamics
The Receptor Binding Domain (RBD) of SARS-CoV-2 virus harbors a sequence of Arg-Gly-Asp tripeptide named RGD motif, which has also …
Article scientifique
Potential Value of TNF-α (–376 G/A) Polymorphism and Cystatin C (CysC) in the Diagnosis of Sepsis Associated Acute Kidney Injury (S-AK I) and Prediction of Mortality in Critically Ill patients
Sepsis Associated Kidney Injury represents a major health concern as it is frequently associated with increased risk of mortality and …
Article scientifique
Metabolomics as a Tool to Investigate HIV/TB Co-Infection
The HIV/AIDS (human immunodeficiency virus/acquired immunodeficiency syndrome) and tuberculosis (TB) pandemics are perpetuated by a significant global burden of HIV/TB …
Article scientifique
The Hepatoprotective Effect of Piperine Against Thioacetamide-Induced Liver Fibrosis in Mice: The Involvement of miR-17 and TGF-β/Smads Pathways
Liver fibrosis is characterized by a series of events including activation of quiescent hepatic stellate cells (HSCs) into proinflammatory, contractile, …
Article scientifique
Application of Computational Methods in Understanding Mutations in Mycobacterium tuberculosis Drug Resistance
The emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) impedes the End TB Strategy by the World Health Organization aiming …
Article scientifique
The Role of Indoor Plants in air Purification and Human Health in the Context of COVID-19 Pandemic: A Proposal for a Novel Line of Inquiry
The last two decades have seen the discovery of novel retroviruses that have resulted in severe negative consequences for human …
Article scientifique
Theranostic Mesoporous Silica Nanoparticles Loaded With a Curcumin-Naphthoquinone Conjugate for Potential Cancer Intervention
A novel theranostic molecule, derived from curcumin (Cur) and naphthoquinone (NQ), allowing for cancer targeting, detection and treatment was previously …
Article scientifique
New Insights Into Potential Benefits of Bioactive Compounds of Bee Products on COVID-19: A Review and Assessment of Recent Research
The recent emergence of COVID-19 represents one of the biggest challenges facing the world today. Despite the recent attempts to …