486 publication(s) trouvée(s)
Article scientifique
Forcing a square into a circle: why South Africa’s draft revised material transfer agreement is not fit for purpose
The South African National Health Research Ethics Council (NHREC) recently released a final draft revision of the standard material transfer …
Article scientifique
The ethnomedicine, phytochemistry, and pharmacological properties of the genus Bersama: current review and future perspectives
Bersama (Melianthaceae) has been used in traditional medicine for a wide range of ailments, including blood purifier, immune booster, psychotropic …
Éditorial
Editorial: Therapeutic potential of natural products in oxidative and metabolic diseases
Keywords: phytochemicals, functional foods, oxidative stress, diabetes, obesity, cardiovascular diseases
Article scientifique
In vitro and in silico studies reveal antidiabetic properties of arylbenzofurans from the root bark of Morus mesozygia Stapf
Diabetes remains an important disease worldwide with about 500 million patients globally. In tropical Africa, Morus mesozygia is traditionally used …
Article scientifique
New insights into the anticancer effects of Polycladia crinita aqueous extract and its selenium nanoformulation against the solid Ehrlich carcinoma model in mice via VEGF, notch 1, NF-кB, cyclin D1, and caspase 3 signaling pathway
The PCSeNPs mediated their promising anti-cancerous action by enhancing apoptosis and mitigating inflammation, which manifested in promoting the total survival …
Article scientifique
Comparative evaluation of antioxidant activity, total phenolic content, anti-inflammatory, and antibacterial potential of Euphorbia-derived functional products
This study assessed the medicinal properties of Euphorbia resinifera O. Berg (E. resinifera) and Euphorbia officinarum subsp echinus (Hook.f. and …
Article scientifique
Annona Muricata L. extract restores renal function, oxidative stress, immunohistochemical structure, and gene expression of TNF-α, IL-β1, and CYP2E1 in the kidney of DMBA-intoxicated rats
Introduction: 7,12-dimethylbenz (a) anthracene (DMBA) is a harmful polycyclic aromatic hydrocarbon derivative known for its cytotoxic, carcinogenic, and mutagenic effects …
Article scientifique
Comparative effects of incretin-based therapy on doxorubicin-induced nephrotoxicity in rats: the role of SIRT1/Nrf2/NF-κB/TNF-α signaling pathways
Introduction: Nephrotoxicity represents a major complication of using doxorubicin (DOX) in the management of several types of cancers. Increased oxidative …
Article scientifique
In vitro cytotoxicity of Withania somnifera (L.) roots and fruits on oral squamous cell carcinoma cell lines: a study supported by flow cytometry, spectral, and computational investigations
Oral cancer is a severe health problem that accounts for an alarmingly high number of fatalities worldwide. Withania somnifera (L.) …
Article scientifique
Glycaemic abnormalities induced by small molecule tryosine kinase inhibitors: a review
In light of the expected increase in the prevalence of diabetes mellitus due to an aging population, sedentary lifestyles, an …
Article scientifique
Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat
In this current study, we explored the preventive capacity of the aqueous extract of Orobanche foetida (OF), a root holoparasite, …
Article scientifique
Comparison of knowledge, attitude, practice and predictors of self-medication with antibiotics among medical and non-medical students in Tanzania
Introduction: Self-medication with antibiotics (SMA) is a widespread problem in developing nations, including Tanzania. Methods: This study compared knowledge, attitudes, …
Article scientifique
Bioactivity and toxicity of coumarins from African medicinal plants
Introduction: Coumarins are naturally occuring metabolites from plants and a few micro-organisms. They have been widely used in the food …
Article scientifique
Antibiotic action and resistance: updated review of mechanisms, spread, influencing factors, and alternative approaches for combating resistance
Antibiotics represent a frequently employed therapeutic modality for the management of bacterial infections across diverse domains, including human health, agriculture, …
Éditorial
Editorial: Implication of oxidative, inflammatory, apoptotic and autophagy pathways in colitis
Ulcerative colitis (UC), is a chronic inflammatory disorder of the colonic mucosa and is characterized by repeated cycles of relapse …
Article scientifique
Translation of preclinical ethnomedicine data in LMICs: the example of rooibos
All disease, but especially non-communicable diseases, are related to dysfunction of one or more regulatory systems. In developing countries, long-term …
Article scientifique
Antinociceptive and antiinflammatory activities of crude leave extract and solvent fractions of Commelina latifolia Hochst. ex C.B.Clarke (Commelinaceae) leaves in murine model
Ethnopharmacological relevance: In the past, Ethiopian traditional medicine employed the leaves of the native Commelina latifolia Hochst. ex C.B. Clarke …
Article scientifique
Radioprotective potential of whey protein against gamma irradiation-induced lingual damage
Introduction: Ionizing radiation (IR) is effectively used in the treatment of oral malignancies; however, it might also significantly harm the …
Article scientifique
Liability for harm caused by AI in healthcare: an overview of the core legal concepts
The integration of artificial intelligence (AI) into healthcare in Africa presents transformative opportunities but also raises profound legal challenges, especially …
Article scientifique
Does data protection law in South Africa apply to pseudonymised data?
The use of pseudonymised datasets is increasingly commonplace as research institutions seek to balance data utility with data security. Yet, …