486 publication(s) trouvée(s)
Article scientifique
In silico and in vivo evaluations of multistage antiplasmodial potency and toxicity profiling of n-Hexadecanoic acid derived from Vernonia amygdalina
Background Despite the widely reported potentials of n-Hexadecanoic acid (HA) as a bioactive, its multi-stage antiplasmodial activity and toxicity profiles …
Article scientifique
Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review
Antibacterial drug resistance poses a significant challenge to modern healthcare systems, threatening our ability to effectively treat bacterial infections. This …
Article scientifique
Influence of fecal fermentation on the anthelmintic activity of proanthocyanidins and ellagitannins against human intestinal nematodes and Caenorhabditis elegans
Some tannin-rich plants such as Combretum mucronatum and Phyllanthus urinaria are widely used in Africa for the control of parasitic …
Article scientifique
Medicinal plants used in Gabon for prophylaxis and treatment against COVID-19-related symptoms: an ethnobotanical survey
Background: Gabon faced COVID-19 with more than 49,000 individuals tested positive and 307 recorded fatalities since the first reported case …
Article scientifique
Superior cuproptotic efficacy of diethyldithiocarbamate-Cu4O3 nanoparticles over diethyldithiocarbamate-Cu2O nanoparticles in metastatic hepatocellular carcinoma
Metastatic hepatocellular carcinoma (HC) is a serious health concern. The stemness of cancer stem cells (CSCs) is a key driver …
Article scientifique
Treatment satisfaction and medication adherence and predictors among patients with heart failure in Ethiopia: a hospital-based cross-sectional study
Background Globally, about 18 million people died from cardiovascular diseases (CVDs) in 2019, over three-quarters in developing countries. Non-adherence to …
Article scientifique
Medicinal plants used by traditional medicine practitioners in treatment of alcohol-related disorders in Bushenyi District, southwestern Uganda
Background: Alcohol-related disorders rank seventh among risk factors for morbidity and mortality globally, posing a significant public health burden. In …
Article scientifique
Phytochemical analysis, in-vitro and in-silico study of antiproliferative activity of ethyl acetate fraction of Launaea cornuta (Hochst. ex Oliv. & Hiern) C. Jeffrey against human cervical cancer cell line
Introduction: Cervical cancer is one of the leading causes of death among women globally due to the limitation of current …
Article scientifique
Ricinodendron heudelotii (Euphorbiaceae) seed oil prevents DMBA-induced breast cancer under menopause-like conditions in Wistar rats
Despite efforts, breast cancer remains associated with a high incidence and mortality rate. Ricinodendron heudelotii also known as “Njansang,” is …
Article scientifique
New insights into the potential cardioprotective effects of telmisartan and nanoformulated extract of Spirulina platensis via regulation of oxidative stress, apoptosis, and autophagy in an experimental model
Background: Cardiotoxicity is one of the limiting side effects of the commonly used anticancer agent cyclophosphamide (Cyclo). Materials and methods: …
Article scientifique
Exploring the link between pyrethroids exposure and dopaminergic degeneration through morphometric, immunofluorescence, and in-silico approaches: the therapeutic role of chitosan-encapsulated curcumin nanoparticles
Introduction: The synthetic pyrethroid derivative fenpropathrin (FNE), a commonly used insecticide, has been associated with various toxic effects in mammals, …
Article scientifique
Supplementation of Saussurea costus root alleviates sodium nitrite-induced hepatorenal toxicity by modulating metabolic profile, inflammation, and apoptosis
Sodium nitrite (NaNO 2 ) is a widely used food ingredient, although excessive concentrations can pose potential health risks. In …
Article scientifique
Phytic acid attenuates acetaminophen-induced hepatotoxicity via modulating iron-mediated oxidative stress and SIRT-1 expression in mice
Introduction: Administration of high doses of acetaminophen (APAP) results in liver injury. Oxidative stress and iron overload play roles in …
Erratum
Corrigendum: An in vitro study to elucidate the effects of Product Nkabinde on immune response in peripheral blood mononuclear cells of healthy donors
[This corrects the article DOI: 10.3389/fphar.2024.1308913.].
Article scientifique
Exploring nature’s antidote: unveiling the inhibitory potential of selected medicinal plants from Kisumu, Kenya against venom from some snakes of medical significance in sub-Saharan Africa
Background: The present study investigated the efficacy of Conyza bonariensis, Commiphora africana, Senna obtusifolia, Warburgia ugandensis, Vernonia glabra, and Zanthoxylum …
Article scientifique
Tripled likelihood: polypharmacy increases the occurrence of drug therapy problems in hospitalized pediatric patients
Background: A drug therapy problem (DTP) is any undesirable event experienced by a patient that accompanies drug therapy, prevents the …
Article scientifique
Traditional herbal medicine regulatory implementation in Ethiopia: a qualitative study
Background: Approximately 80% of the Ethiopian population predominantly depends on herbal medicines (HMs) for their primary healthcare needs. Nevertheless, worries …
Erratum
Corrigendum: Unveiling the therapeutic potential of exogenous β-hydroxybutyrate for chronic colitis in rats: novel insights on autophagy, apoptosis, and pyroptosis
[This corrects the article DOI: 10.3389/fphar.2023.1239025.].
Article scientifique
A pathway to strengthening open science: comments on the draft South African Ethics in Health Research Guidelines
The recently releaseddraft South African Ethics in Health Research Guidelines: Principles, Processes and Structures(Draft Guidelines) by the National Health Research …
Erratum
Corrigendum: Liability for harm caused by AI in healthcare: an overview of the core legal concepts
[This corrects the article DOI: 10.3389/fphar.2023.1297353.].