486 publication(s) trouvée(s)
Article scientifique
Comparison of enteral prucalopride versus intravenous metoclopramide for feeding intolerance in patients with critical illness: a randomized double-blinded study
Background Feeding intolerance is commonly experienced during enteral feeding, necessitating cessation. Metoclopramide may be given to assist gastric emptying, but …
Article scientifique
PU-H71 (NSC 750424): a molecular masterpiece that targets HSP90 in cancer and beyond
Heat shock protein 90 (HSP90) is a pivotal molecular chaperone with multifaceted roles in cellular health and disease. Herein, we …
Article scientifique
Efficacy of the cardiac glycoside digoxin as an adjunct to csDMARDs in rheumatoid arthritis patients: a randomized, double-blind, placebo-controlled trial
Background Inflammation and angiogenesis are two main mechanisms that act as mutual pathways in rheumatoid arthritis (RA). This work aimed …
Article scientifique
Family Malvaceae: a potential source of secondary metabolites with chemopreventive and anticancer activities supported with in silico pharmacokinetic and pharmacodynamic profiles
Introduction: Cancer is the second most widespread cause of mortality following cardiovascular disorders, and it imposes a heavy global burden. …
Article scientifique
Antidiabetic potential of Lavandula stoechas aqueous extract: insights into pancreatic lipase inhibition, antioxidant activity, antiglycation at multiple stages and anti-inflammatory effects
Background With the increasing global prevalence of type 2 diabetes (T2D) and obesity, there is a pressing need for novel …
Éditorial
Editorial: Pharmacological actions of drugs in the brain: exploring the intricacies and potential therapeutic applications
The brain's intricate and dynamic nature has made it a focal point of pharmacological research, with the goal of understanding …
Article scientifique
Mitigative role of cysteamine against unilateral renal reperfusion injury in Wistar rats
Background Ischemia-reperfusion injury (IRI) is unavoidable during kidney transplant and it is responsible for delayed or non-function after kidney transplantation. …
Article scientifique
Highly active antiretroviral therapy adherence among HIV-POSITIVE women in Southern Ethiopia
Background: Adherence to Highly Active Antiretroviral Therapy (HAART) medication is the major predictor of HIV/AIDS treatment success. Poor adherence to …
Article scientifique
Ethnobotanical survey and scientific validation of liver-healing plants in northeastern Morocco
Introduction: Liver diseases represent a significant global health challenge, with primary causes including excessive alcohol consumption, infections, chemotherapy, and autoimmune …
Article scientifique
Medicinal plants diversity among the oromo community in heban-arsi district of Ethiopia used to manage human and livestock ailments
Introduction Medicinal plants are commonly employed mainly due their accessibility, affordability and potency. However, medicinal plants and the associated knowledge …
Article scientifique
STA-9090 in combination with a statin exerts enhanced protective effects in rats fed a high-fat diet and exposed to diethylnitrosamine and thioacetamide
Introduction: Liver fibrosis is a significant global health burden that lacks effective therapies. It can progress to cirrhosis and hepatocellular …
Article scientifique
Activation of AMPK/SIRT1/FOXO3a signaling by BMS-477118 (saxagliptin) mitigates chronic colitis in rats: uncovering new anti-inflammatory and antifibrotic roles
Ulcerative colitis (UC) is a debilitating chronic disease marked by persistent inflammation and intestinal fibrosis. Despite the availability of various …
Article scientifique
Chitosan/hesperidin nanoparticles formulation: a promising approach against ethanol-induced gastric ulcers via Sirt1/FOXO1/PGC-1α/HO-1 pathway
Hesperidin (Hes) protects different organs from damage by acting as a potent antioxidant and anti-inflammatory. This study aims to evaluate …
Erratum
Corrigendum: Effect of a high dose atorvastatin as added-on therapy on symptoms and serum AMPK/NLRP3 inflammasome and IL-6/STAT3 axes in patients with major depressive disorder: randomized controlled clinical study
on therapy on symptoms and serum AMPK/NLRP3 inflammasome and IL-6/STAT3 axes in patients with major depressive disorder: randomized controlled clinical …
Éditorial
Drug outcomes research and policies – trends and challenges
outcomes research, pharmaceutical policies, effectiveness trials, health technology assessment, patient-reported outcomes, healthcare delivery, equityOutcomes research quantifies the results of medical …
Article scientifique
Prescription patterns and therapeutic gaps among persons with epilepsy in Southwestern Nigeria
Introduction: Pharmacotherapy with antiseizure medications (ASMs) has been a cornerstone for achieving long-term remissions in persons with epilepsy (PWEs). This …
Article scientifique
The anatomy of a data transfer agreement for health research
In a data-driven era, the exchange and safeguarding of personal information has become paramount. Data transfer agreements (DTAs) serve to …
Article scientifique
11-Hydroxyeicosatetraenoics induces cellular hypertrophy in an enantioselective manner
Background: R/S enantiomers of 11-hydroxyeicosatertraenoic acid (11-HETE) are formed from arachidonic acid by enzymatic and non-enzymatic pathways. 11-HETE is predominately …
Article scientifique
Suppression of NLRP3 inflammasome orchestrates the protective efficacy of tiron against isoprenaline-induced myocardial injury
The major contribution of myocardial damage to global mortalities raises debate regarding the exploration of new therapeutic strategies for its …
Article scientifique
Plant-based nanoparticles targeting malaria management
Malaria is one of the most devastating diseases across the globe, particularly in low-income countries in Sub-Saharan Africa. The increasing …