486 publication(s) trouvée(s)
Article scientifique
Neuroprotective potential of selenium nanoparticles and/or physical and mental activities against social isolation–induced depression in a rat model: inflammatory, oxidative stress, apoptotic, and neurotransmission modulatory pathways
Background: Social isolation (SI), attributable to modern lifestyles and fast-growing technology, is a leading cause of depression. Selenium nanoparticles (Se-NPs) …
Article scientifique
The protective efficacy of baricitinib against lipopolysaccharide / D-Galactosamine–Induced acute liver Injury
Intorduction: Baricitinib (BARI), the selective JAK1/JAK2 inhibitor demonstrates enhanced immunological activity against several inflammatory conditions. Given the complex, multiple pathogeneses …
Article scientifique
Sperm-disrupting activity of a root bark fraction of Flueggea virosa (Roxb. ex willd.) royle uncovered using LC-MS/MS profiling and functional evaluation
Introduction While Flueggea virosa (Roxb. Ex Willd.) Royle root bark is traditionally used in several parts of East Africa for …
Article scientifique
Taurine attenuates polystyrene microplastic–associated oxidative stress, inflammation, and apoptotic changes in the spleen of mice
Introduction: Microplastic (MP) contamination is an emerging environmental threat with potential adverse effects on oxidative stress, immune function, and inflammatory …
Article scientifique
Challenges and pathways to herbal ethical approval: an institutional case study of a randomized controlled trial on Moringa oleifera Lam.
Clinical trials are essential for validating the safety and efficacy of traditional medicines; however, their conduct in Africa is significantly …
Article scientifique
Cepharanthine improves blood glucose levels and mitigates renal injury in streptozotocin-induced diabetic rats via restoring pancreatic β-cell integrity and reducing inflammation
Background/Objectives: We have previously demonstrated that the natural alkaloid Cepharanthine (Ceph) reduces renal injury in streptozotocin (STZ)-induced insulin-deficient diabetic rats …
Article scientifique
Polyphenol-enriched fraction of Acacia seyal Delile (Mimosaceae) inhibits human triple-negative breast cancer cells and exhibits anticancer and immunomodulatory effects in a DMBA-induced breast cancer model
Introduction Breast cancer killed 665,684 patients globally in 2022 despite government efforts and conventional therapies. The hydro-ethanolic extract of Acacia …
Erratum
Correction: Discovery of potent bisindole-based pyrazolopyridine derivatives as topoisomerase inhibitors: DNA damage induction and synergistic antileukemic activity
[This corrects the article DOI: 10.3389/fphar.2026.1745220.].
Article scientifique
In-vivo antidiarrheal activity of aqueous and hydroethanolic extracts of Anacardium occidentale and Khaya senegalensis used in Benin (West Africa) in a castor oil-induced diarrhea model traditionally
Background The management of diarrheal diseases involves the use of medicinal plants, particularly in developing countries, where access to conventional …
Article scientifique
Comparative neuroprotective and exercise capacity effects of prophylactic intermittent fasting and probiotics in sleep-deprived rats: insights into anti-inflammatory marker modulation and CLOCK gene regulation
Background Prophylactic probiotics and intermittent fasting (IF) substantially modulate the neuropsychological functions and exercise capacity in rats subjected to sleep …
Article scientifique
Enhancing secondary metabolite accumulation in medicinal plants to improve immunomodulatory activity
Despite progress in enhancing secondary metabolite accumulation to support plant growth and stress tolerance, relatively few studies have established direct …
Article scientifique
A comprehensive review of ischemic heart disease: pathophysiology, current treatments, natural products-based therapies, and nanotherapeutics
Ischemic heart disease (IHD) is one of the major cardiovascular disorders leading to global morbidity and mortality and represents a …
Article scientifique
Exploring the association between pharmacy curricular tracks and students’ attitudes toward generic medicines: insights from a comparative study in Egypt
Background: Use of generic medicines enhances drug affordability and accessibility. The aim if this study was to assess the association …
Article scientifique
African traditional medicine: historical legacy, colonial disruption, and pathways for integration into modern healthcare
African Traditional Medicine (ATM) remains an important component of healthcare across Africa and continues to play a significant role within …
Article scientifique
Regulation of doxorubicin resistance and cellular metabolism by miR-203a-3p via p53 and TAp63 signaling in hepatocellular carcinoma
Doxorubicin (DOX) is a cornerstone chemotherapeutic drug in the treatment of hepatocellular carcinoma (HCC). However, its efficacy is often limited …
Article scientifique
Modulation of NF-κB and cytokine signaling by Cordia dichotoma and Cordia myxa attenuates methotrexate-induced pulmonary inflammation and oxidative injury in rats
Background Methotrexate (MTX) is a widely used anticancer and immunosuppressive agent, but its clinical use is limited by lung injury …
Article scientifique
Cannabis sativa phytochemicals in cancer therapy: molecular mechanisms and therapeutic potential
Background The therapeutic potential of Cannabis sativa has attracted growing interest in oncology. Its diverse phytochemicals, including cannabinoids, flavonoids, and …
Erratum
Correction: Empagliflozin attenuates dexamethasone-induced non-alcoholic steatohepatitis by regulation of ferroptosis, inflammation and autophagy
[This corrects the article DOI: 10.3389/fphar.2026.1741926.].
Article scientifique
A dual edge-activation strategy for rhein bilosomes enhances intradermal delivery and anti-melanoma efficacy
Introduction: The therapeutic potential of rhein (RH) in topical melanoma management is constrained by its poor aqueous solubility and limited …
Article scientifique
Allelopathic effects of four spontaneous plants from arid regions on the germination and growth of selected weeds and crops
The study investigates the allelopathic potential of the aqueous extracts of four plants species; Cleome arabica L., Diplotaxis harra (Forssk.) …