486 publication(s) trouvée(s)
Article scientifique
Pharmacogenomics of treatment toxicities in pediatric B-Cell ALL: toward safer precision therapy
Pharmacogenomics (PGx) has emerged as a key strategy to predict and prevent drug hypersensitivity reactions and treatment-related toxicities, thereby improving …
Article scientifique
Neurodegeneration at the crossroads: the gut-brain axis and blood-brain barrier in Parkinson’s disease — a review
Parkinson's disease (PD), which is one of the most common neurodegenerative illnesses, involves abnormal deposition of α-Synuclein and loss of …
Article scientifique
An integrative neuropharmacological review of Huntington’s disease challenges and the role of novel formulations in addressing pharmacological‒pharmaceutical limitations
Background: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by CAG repeat expansion in the huntingtin gene, leading …
Article scientifique
Neuroprotective effects of rutin, sodium selenite, and rutin-conjugated selenium nanoparticles in a social isolation model
Background Social isolation (SI) is a long-standing experimental paradigm that models schizophrenia-like behavioural and neurobiological changes caused by the action …
Article scientifique
Preliminary evaluation of a monovalent antivenom targeting Cerastes cerastes envenomation in North Africa: feasibility and specificity assessment
In 2017, the World Health Organization (WHO) recognized snakebite envenomation as a neglected disease yet the therapeutic effectiveness efficacy of …
Éditorial
Commentary: Perceptions and attitudes toward clinical trial participation: a study on Moringa oleifera Lam. supplementation in adult HIV patients in Kano State, Nigeria
Clinical trials conducted in low-and middle-income countries frequently report challenges related to recruitment, retention, and protocol adherence (Tindana et al., …
Article scientifique
Dual-mechanism of phytochemicals in cancer therapy: synergistic anti-angiogenic potency in cancer and proangiogenic impact against chemotherapy-induced cytotoxicity in vital organs
Angiogenesis is essential for tumor growth and metastasis, yet physiological angiogenesis is equally critical for tissue repair and endothelial homeostasis. …
Éditorial
Editorial: Enhancing cancer therapy: integrating plant-derived bioactives with chemotherapy through traditional knowledge and modern advances
The prevalence of cancer, which has a huge negative impact on both global health and economy, is still one of …
Article scientifique
Thymoquinone combined with conventional antibiotics against pandrug-resistant Staphylococcus aureus: a pharmacodynamic and molecular simulation strategy to overcome bioavailability limitations
Background Infections with pandrug-resistant (PDR) Staphylococcus aureus ( S. aureus ) present no available treatment alternatives, even when employing most …
Article scientifique
Factors associated with inappropriate antibiotic use in South African communities: findings from the CAMUS survey
Background Inappropriate antibiotic use in the community is a primary driver of antimicrobial resistance (AMR), particularly in low- and middle-income …
Article scientifique
Preclinical evidence of the therapeutic effect of Moringa oleifera in peptic ulcer disease: a systematic review and meta-analysis
Background Peptic ulcer disease (PUD) remains a global health burden, with current therapies limited by recurrence, adverse effects, and high …
Article scientifique
A call to action for pharmacogenomics stewardship in South Africa
Pharmacogenomics (PGx) can personalize medication therapy in South Africa's (SA) diverse populativon but faces context-specific barriers: inadequate SA-specific allele variant …
Article scientifique
Empagliflozin attenuates dexamethasone-induced non-alcoholic steatohepatitis by regulation of ferroptosis, inflammation and autophagy
Purpose: rats. Methods: NASH was induced by daily injection of DEXA (8 mg/kg/day, i.p.) from day 8-13. EMPA (10 and …
Article scientifique
Discovery of potent bisindole-based pyrazolopyridine derivatives as topoisomerase inhibitors: DNA damage induction and synergistic antileukemic activity
Introduction The development of novel anticancer agents targeting DNA replication and repair mechanisms remains a priority in leukemia therapy. In …
Article scientifique
Exploring the therapeutic potential of naturally occurring taxifolin, a dietary flavonoid: an updated comprehensive review
Purpose: Flavonoids, well-known as key bioactive compounds in numerous medicinal plants, help protect these plants against both biotic and abiotic …
Article scientifique
An ethnopharmacological assessment of medicinal plants in Malanje Municipality, Angola
Background Malanje Municipality in north-central Angola harbors exceptional botanical and cultural diversity, yet remains poorly documented for traditional medicinal plant …
Éditorial
Editorial: Innovative strategies for overcoming resistance in tumor angiogenesis therapies
cohort. The authors call for the development of predictive biomarkers and novel drug combinations to further enhance outcomes.In conclusion, the …
Article scientifique
Ethnopharmacological considerations of plants traditionally used by local communities to manage maternal conditions in Tanzania: a scoping review
Ethnopharmacological relevance Despite notable progress in maternal health and a reduction in maternal mortality rates, Tanzania still falls short of …
Article scientifique
Unraveling the role of 3-mercaptopyruvate sulfurtransferase-derived hydrogen sulfide in triple-negative breast cancer chemoresistance
Background Triple-negative breast cancer (TNBC) frequently develops resistance to chemotherapy. Cancer-supporting roles of the endogenous gaseous mediator hydrogen sulfide (H …
Article scientifique
Combined azelastine fluticasone nasal spray versus fluticasone propionate nasal spray in postoperative management of central compartment atopic disease (CCAD)
Background: Central compartment atopic disease (CCAD) is a subtype of chronic rhinosinusitis with nasal polyps (CRSwNP), distinguished by polypoid changes …