486 publication(s) trouvée(s)
Article scientifique
Beyond antipsychotic efficacy and toward an individualized therapeutic strategy: analysis of the systemic, metabolic, and inflammatory effects of olanzapine, haloperidol, and their combination in schizophrenic patients
Introduction: Olanzapine (OLZ), haloperidol (HALP), and their combination, are widely used antipsychotics; the majority of studies focuses on their therapeutic …
Article scientifique
Evaluation of trimetazidine in alleviating paclitaxel-induced peripheral neuropathy in breast cancer patients: a randomized controlled trial
Background: Paclitaxel-induced peripheral neuropathy is a frequent chemotherapy complication that causes nerve damage and profoundly reduces patients' quality of life. …
Éditorial
Editorial: Digital health innovations in Africa: harnessing AI, telemedicine, and personalized medicine for improved healthcare
The healthcare landscape in Africa is undergoing a transformative shift driven by the integration of Artificial Intelligence (AI), telemedicine, and …
Article scientifique
Ketoprofen-loaded quatsomes as a smart repurposed antifungal therapy for vaginal infections: formulation, characterization, and microbiological evaluation
Introduction Vulvovaginal candidiasis (VVC) is one of the most common fungal infections requiring more effective and patient-friendly therapies. This study …
Article scientifique
Inflammatory and chemotactic signals of the brainstem solitary tract mediate the morphine exacerbation of impaired reflex chronotropism in septic rats
Introduction The interplay between opioid analgesics and sepsis in intensive care units (ICUs) is multifaceted, often amplifying immune dysregulation and …
Article scientifique
Real-world clinical outcomes of EKOS catheter-directed thrombolysis versus systemic alteplase in acute pulmonary embolism: a retrospective cohort study
Background: The use of EkoSonic Endovascular System (EKOS) that combines ultrasound technology with catheter-directed thrombolysis has shown promising outcomes in …
Article scientifique
Exploring cannabinoid modulation on autophagy mechanisms in Alzheimer’s disease: a review
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of toxic protein aggregates in the brain, leading to …
Article scientifique
Identification of novel germline and somatic mutations associated with hepatocellular carcinoma by next-generation sequencing
Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated deaths worldwide with an estimated of 900,000 new cases …
Article scientifique
Ethnopharmacological insights into uterine fibroids: a review of etiology, and therapeutic potential of natural products
Uterine fibroids (leiomyomas) are the most common benign gynecologic tumors, affecting up to 80% of women by age 50, with …
Article scientifique
Studying the potential ameliorative effect of biosynthesized selenium nanoparticles using epigallocatechin gallate against depression in rats
Introduction: Major depressive disorder (MDD) is a complex neuropsychiatric disorder with multifactorial origins involving oxidative stress, neuroinflammation, neurotransmitter imbalance, and …
Article scientifique
Innovative dual-functional hybrid cationic PEGylated proniosomes as a smart nano-platform for Boosted vaginal delivery: multi-level in-vitro, ex-vivo, microbiological, and in-vivo studies
Introduction: Vaginal candidiasis remains a recurrent fungal infection affecting millions of women worldwide, necessitating innovative local delivery systems to overcome …
Article scientifique
Bioactive compounds from Tetradenia riparia and Tetracera poggei: antioxidant activity, UPLC-QTOF-MS phytochemical profiling, and in silico targeting of the RNA-binding protein DRBD18 of Trypanosoma brucei
Oxidative stress has been implicated in the pathogenesis of African trypanosomiasis. Therefore, plant-derived antioxidants have been investigated as potential therapeutic …
Article scientifique
Lurasidone ameliorates doxorubicin-induced chemobrain in male Wistar rats: involvement of the hippocampal and prefrontal cortex CREB/BDNF/Glt-1 axis and glutamate homeostasis
Introduction: Chemotherapy-induced cognitive impairment, commonly referred to as "chemobrain", represents a frequent and distressing complication of cancer therapy. Doxorubicin (DOX), …
Article scientifique
Microbiome-aware oral drug delivery: excipient–microbiome interactions and nanocarrier design rules for predictable formulation performance
Oral drug delivery remains the predominant administration route, but formulation strategies rarely account systematically for the gut microbiome. The microbiome …
Article scientifique
A narrative review of emerging chemoprotective agents for chemotherapy-induced toxicity: nanoformulated natural products, dual COX-2/TNF-α inhibitors, and Nrf2 modulators
Background: Chemotherapy-induced toxicity remains a major cause of treatment discontinuation, reduced quality of life, and long-term morbidity in cancer survivors. …
Erratum
Correction: Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress
In the published article, there was an error in [Table 1] as published. [There was a mistake in the accession …
Article scientifique
The biological screening of aromatic medicinal plant extracts for their potential in vitro bioactivity against factors associated with breast mastitis
Breast mastitis is an inflammatory condition caused by pathogenic infection, which is usually treatable with antibiotics, yet there is a …
Article scientifique
Advanced hybrid-stabilized cinacalcet nanocrystals for enhanced oral bioavailability: formulation and integrated in vitro/in vivo evaluations
Introduction Cinacalcet (CINA), a Biopharmaceutics Classification System (BCS) Class IV drug, exhibits limited oral bioavailability due to poor aqueous solubility …
Article scientifique
Bromhexine hydrochloride enhances the therapeutic efficacy of tiamulin against experimental Staphylococcus aureus infection in dogs: targeting bacterial virulence, boosting antioxidant defense, and improving histopathology
Introduction Staphylococcus aureus is a prominent pathogen capable of causing systemic infections and multi-organ damage, primarily driven by its high …
Article scientifique
Comparative study of the registration procedure of locally manufactured herbal products in selected African countries
Background: Recognizing the widespread use of herbal medicines, regulating them to ensure their safe registration, quality, and efficacy is of …