486 publication(s) trouvée(s)
Article scientifique
Escitalopram Ameliorates Cardiomyopathy in Type 2 Diabetic Rats via Modulation of Receptor for Advanced Glycation End Products and Its Downstream Signaling Cascades
Type 2 diabetes mellitus (T2DM) has been recognized as a known risk factor for cardiovascular diseases. Additionally, studies have shown …
Article scientifique
Dibenzazepine Attenuates Against Cisplatin-Induced Nephrotoxicity in Rats: Involvement of NOTCH Pathway
Cisplatin is one of the standard anti-cancer agents that are used to treat variety of solid tumors. Nevertheless, due to …
Article scientifique
SARS-CoV-2 Spike-Heat Shock Protein A5 (GRP78) Recognition may be Related to the Immersed Human Coronaviruses
The human coronavirus (HCoV), SARS-CoV-2, caused more than 34 M confirmed infections from which more than 1 M deaths are …
Article scientifique
Tetrahydrocannabinol-Rich Extracts From Cannabis Sativa L. Improve Glucose Consumption and Modulate Metabolic Complications Linked to Neurodegenerative Diseases in Isolated Rat Brains
Reduced brain glucose consumption arising from impaired glucose uptake and utilization has been linked to the pathogenesis and complications of …
Article scientifique
Countrywide Survey of Plants Used for Liver Disease Management by Traditional Healers in Burkina Faso
Liver disease is highly prevalent in Africa, especially in the western African country Burkina Faso, due to the presence of …
Article scientifique
COVID-19 Genetic and Environmental Risk Factors: A Look at the Evidence
family and is closely related to the virus responsible for the severe acute respiratory Syndrome (SARS). Since December 2019, the …
Article scientifique
National Consumption of Antimicrobials in Tanzania: 2017–2019
Objective: Surveillance of antimicrobial consumption is essential to the national action plan for antimicrobial resistance (AMR) as stipulated in the …
Article scientifique
Anti-Melanoma Activities of Artemisone and Prenylated Amino-Artemisinins in Combination With Known Anticancer Drugs
The most frequently occurring cancers are those of the skin, with melanoma being the leading cause of death due to …
Article scientifique
L-Carnitine Mitigates Oxidative Stress and Disorganization of Cytoskeleton Intermediate Filaments in Cisplatin-Induced Hepato-Renal Toxicity in Rats
Cisplatin (CP) is one of the most active medications in cancer treatment and has some adverse effects such as hepatotoxicity …
Article scientifique
Anti-SARS-CoV Natural Products With the Potential to Inhibit SARS-CoV-2 (COVID-19)
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), known to cause the disease COVID-19, was declared a pandemic in early 2020. …
Article scientifique
Response to the Novel Corona Virus (COVID-19) Pandemic Across Africa: Successes, Challenges, and Implications for the Future
BACKGROUND: The COVID-19 pandemic has already claimed considerable lives. There are major concerns in Africa due to existing high prevalence …
Article scientifique
A Retrospective Audit of Pharmacologic and Non-Pharmacologic Management of Childhood Acute Asthma Exacerbation at Usmanu Danfodiyo University Teaching Hospital, Sokoto: Adherence to Global Treatment Guidelines
BACKGROUND: Adequate management of childhood acute asthma exacerbation requires optimal non-pharmacotherapy and pharmacotherapy. Global asthma guidelines provide critical information and …
Article scientifique
Formulary Management Activities and Practice Implications Among Public Sector Hospital Pharmaceutical and Therapeutics Committees in a South African Province
INTRODUCTION: The World Health Organization identified Pharmaceutical and Therapeutics Committees (PTCs) at district and hospital levels as one of the …
Article scientifique
CYP3A5 Gene-Guided Tacrolimus Treatment of Living-Donor Egyptian Kidney Transplanted Patients
Background: Tacrolimus is an approved first-line immunosuppressive agent for kidney transplantations. Part of interindividual and interethnic differences in the response …
Article scientifique
Anti-Cancer Effects of Lycopene in Animal Models of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Introduction: Globally, hepatocellular carcinoma (HCC) is the sixth most diagnosed cancer and the third important cause of cancer-related death. As …
Article scientifique
The Prophylactic Effect of Pinocembrin Against Doxorubicin-Induced Cardiotoxicity in an In Vitro H9c2 Cell Model
BACKGROUND: The clinical use of Doxorubicin (Dox) is significantly limited by its dose-dependent cardiotoxic side effect. Accumulative evidence suggests that …
Article scientifique
Natural Products Impacting DNA Methyltransferases and Histone Deacetylases
Epigenetics refers to heritable changes in gene expression and chromatin structure without change in a DNA sequence. Several epigenetic modifications …
Éditorial
Editorial: Cosmeceuticals From Medicinal Plants
The use of the word cosmetics comes from kosmétikos, an Ancient Greek term. This word can be \ntranslated as “skilled …
Article scientifique
Surveillance of the Efficacy of Artemisinin–Piperaquine in the Treatment of Uncomplicated Plasmodium falciparum Malaria Among Children Under 5 Years of Age in Est-Mono District, Togo, in 2017
Background Malaria is a major public health concern in Togo. The Est-Mono district of Togo has a population of 150,000. …
Article scientifique
Can Standardisation of the Public Assessment Report Improve Benefit-Risk Communication?
BACKGROUND: National regulatory authorities (NRAs) make the decision to register a medicine based on an assessment of its benefits and …