486 publication(s) trouvée(s)
Article scientifique
Efficacy of using pentoxifylline in patients undergoing breast cancer surgery
Introduction Breast cancer surgery presents several challenges, including postoperative pain, and wound healing complications. Pentoxifylline is a synthetic methylxanthine derivative …
Article scientifique
Dipeptidyl peptidase-4 enzyme inhibition and its impacts on hepatic preneoplasia: a new avenue for liver cancer management
Aims Dipeptidyl peptidase-4 enzyme (DPP-4) was reported to be associated with immune stimulation, resistance to anti-neoplastic agents and lipid accumulation. …
Article scientifique
Investigation of the in vivo and in silico wound healing property of Retama raetam (Forssk) Webb & Berthel. leaves extract
In this study, the wound healing properties of the leaf aqueous extract of Retama raetam (Forssk) Webb & Berthel was …
Article scientifique
Tamarix honey phenolics attenuate cisplatin-induced kidney toxicity by inhibition of inflammation mediated IL-6/STAT3/TNF-α and oxidative stress-dependent Nrf2/caspase-3 apoptotic signaling pathways
Introduction: Cisplatin (CIS) is a productive chemotherapeutic agent that is effective against a variety of cancer types. Its utilization is …
Article scientifique
Hesperidin alleviates hypothyroidism-related cardiac dysfunction by targeting cardiac miRNAs, Nrf2/NF-κB signaling, oxidative stress and inflammation
Background: Hypothyroidism is a frequent endocrine health issue that is linked to adverse cardiovascular events. Accumulating evidence suggests that thyroid …
Article scientifique
Herbal formulations, Product Nkabinde and Gnidia sericocephala, exhibit potent in vitro activity against HIV-1 infection
Background While antiretroviral therapy (ART) has transformed HIV-1 into a manageable chronic illness, its long-term affordability and accessibility remain major …
Article scientifique
Patterns and predictors of self-medication behavior of weight loss medications: a cross-sectional analysis of social media influence and role of pharmacist intervention
Background Misuse of weight-loss medicines, particularly those obtained via the internet and social media, raises critical concerns regarding patient safety, …
Article scientifique
Formulation of zein nanoparticles for augmenting the anti-inflammatory activity of dexketoprofen
Introduction Topical delivery of anti-inflammatory drugs is an important strategy for enhancing therapeutic efficacy while minimizing systemic side effects. This …
Éditorial
Editorial: Global excellence in ethnopharmacology: Africa
African Traditional Medicine (ATM) has a rich history of use in the continent dating back to the dawn of humanity. …
Éditorial
Editorial: Multi-target drug discovery and design for complex health disorders
Editorial: Multi-Target Drug Discovery and Design for Complex Health Disorders Multi-target drug discovery represents a pivotal advancement in addressing complex …
Article scientifique
In vitro antimicrobial and cytotoxic evaluation of leaf, root, and stem extracts of Solanum dasyphyllum and root and stem extracts of Dovyalis abyssinica
Background Plants like Solanum dasyphyllum and Dovyalis abyssinica have been traditionally used to treat ailments such as fevers, asthma, high …
Article scientifique
Salt sensitivity and myocardial fibrosis: unraveling the silent cardiovascular remodeling
Salt sensitivity is a well-recognized contributor to cardiovascular risk, traditionally linked to elevated blood pressure. However, emerging evidence suggests that …
Article scientifique
The protective role of vitamin C against linezolid-induced hepato-renal toxicity in a rat model
This study investigated the protective effects of vitamin C against linezolid-induced hepatotoxicity and nephrotoxicity in rats using biochemical, histopathological, and …
Article scientifique
Protective role of remogliflozin against experimental liver fibrosis by activating AMPK/SIRT1/Nrf2 and suppressing NF-κB pathways
Liver fibrosis is considered an epidemic health problem since it can lead to several insults that can be fatal. Remogliflozin …
Article scientifique
Knowledge, attitudes, and practices of healthcare providers toward ADR reporting regarding thiopurine drugs for the treatment of acute lymphoblastic leukemia at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
Background Knowledge, attitudes, and practices (KAP) regarding the use of thiopurine chemotherapeutic drugs in the treatment of acute lymphoblastic leukemia …
Article scientifique
An ethnopharmacological survey of herbal medicines use among pregnant and postpartum women in Souss Massa (Morocco)
Introduction: Pregnant women use medicinal plants for the treatment of illnesses associated with pregnancy. Women might resort to using medicinal …
Article scientifique
Efficacy and safety of a new drug formulation, amoxicillin-clavulanate-cineole, for adult lower respiratory tract infections: a nationwide observational study in Morocco
Background Lower respiratory tract infections (LRTIs) remain significant global health threats, causing substantial morbidity and mortality. The treatment landscape for …
Article scientifique
Prenatal modulation of NADPH-oxidase reverses the deranged GABA switch and rescues behavioral deficits in valproate ASD rat model
Indroduction: Impaired depolarizing-to-hyperpolarizing (D/H) switch of gamma-aminobutyric acid (GABA) is reported during brain development in rodent valproate-model of autism spectrum …
Article scientifique
Mangiferin mitigates dexamethasone-induced insulin resistance in rats: insight into vascular dysfunction and hepatic steatosis
Aim: Insulin resistance (IR) is a hazard to human health in which peripheral insulin-target organs, like the liver, become less …
Article scientifique
Review of the ethnobotany, phytochemistry, pharmacology, and toxicity studies of the genus Adenia
Background The genus Adenia has a rich history of traditional medicinal use across various cultures, particularly in Africa and parts …