22 publication(s) trouvée(s)
Article scientifique
Duloxetine ameliorates acute pancreatitis-associated inflammation and modulates pain related neuroinflammatory pathways via modulation of SP-related neurokinin signaling and PAR2/TRPV1 pathways
Background: Acute pancreatitis (AP) is an inflammatory pancreatic disorder, often illustrated by neuropathic, inflammatory, and/or visceral pain. Pain is a …
Article scientifique
Oridonin attenuates diclofenac-induced organ damage by suppressing endoplasmic reticulum stress and inflammasome activation
Background: Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) extensively prescribed in clinical practice; its use can be associated with toxic …
Article scientifique
Protective effect of Carica papaya ethanolic leaf extract against lead-induced toxicity in Wistar rats
Introduction Lead poisoning remains a significant public health issue globally, with varied negative health outcomes, particularly in developing countries. Lead …
Article scientifique
Protective effects of Lagerstroemia speciosa against paracetamol-induced renal and testicular toxicity in rats via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms
Introduction: Paracetamol (PCM) is widely used as an analgesic; however, at high doses, it is well recognized for its hepatotoxic …
Article scientifique
Imidacloprid exposure in rats induces cardiac inflammatory response through activating TLR4/NF-κB/NLRP3 and JAK/STAT signaling pathways: focus on the berberine-loaded nanoliposomes
The neonicotinoid insecticide, imidacloprid (IMI), is one of the widely used pesticides with well-documented serious health effects that are noticeable …
Article scientifique
Dose–response toxicity and locomotor effects of Mucuna pruriens-based phytotherapeutic combinations in pesticide-exposed Drosophila melanogaster
Background Mucuna pruriens contains L-3,4-dihydroxyphenylalanine (L-DOPA) and other bioactive constituents with potential relevance to motor dysfunction; however, the safety of …
Article scientifique
Endocrine disruption rewards: bisphenol-A-induced reproductive toxicity and the precision ameliorative potential of flavonoids in preclinical studies. A systematic review and meta-analysis
Introduction Bisphenol A (BPA), a pervasive endocrine-disrupting chemical, impairs male reproductive health via oxidative stress, hormonal dysregulation, and hypothalamic–pituitary–gonadal (HPG) …
Article scientifique
Daflon and Centrum mitigate vancomycin-induced nephrotoxicity in rats by ameliorating oxidative stress, DNA damage, apoptosis, and inflammation
Background: Vancomycin (VM) is widely used for treating life-threatening infections caused by Gram-positive bacteria resistant to other antibiotics. However, its …
Article scientifique
Subchronic effects of HgCl2 on cognitive function and central inflammation in type 2 diabetic rats: involvement of BDNF and acetylcholinesterase
Introduction Type 2 diabetes mellitus (T2DM) is a major global health concern frequently related with chronic low-grade inflammation and a …
Article scientifique
Nutrients and phytochemicals characterisations, acute and sub-acute oral toxicity studies of BobyGuard C, a polyherbal nutraceutical with anti-breast cancer properties
Background In 2022, approximately 2.3 million new cases of female breast cancer and 670,000 related deaths worldwide despite significant advancements …
Article scientifique
Investigating the research landscape of chlorinated paraffins over the past ten decades
Chlorinated paraffins (CPs) are classified as emerging persistent organic pollutants (POPs). Due to their associated environmental and health impacts, these …
Article scientifique
Protective effects of Pelargonium graveolens (geranium) oil against cefotaxime-induced hepato-renal toxicity in rats
Cefotaxime is a broad-spectrum antibiotic targeting Gram-negative bacteria used for diverse infections, but it can be toxic to the stomach, …
Article scientifique
Haematological parameters and biochemical indices of African catfish (Clarias gariepinus) exposed to glyphosate-based herbicide (Force up®) for 96 hours
Introduction Geometric aquaculture growth has resulted in exponentially increasing use of agrochemicals as either parasiticides or herbicides in the aquaculture …
Article scientifique
A systematic review and meta-analysis of the impact of triclosan exposure on human semen quality
Introduction Triclosan is an antibacterial and antifungal compound that is frequently found in personal care and consumer products, and its …
Article scientifique
The use of in vitro bioassays and chemical screening to assess the impact of a minimally processed vegetable facility on wastewater quality
Fruit- and vegetable-processing facilities may contaminate wastewater via contaminants found in the produce and disinfecting chemicals used. These contaminants may …
Article scientifique
Phenolic compounds occurrence and human health risk assessment in potable and treated waters in Western Cape, South Africa
Phenolic pollutants from industrial and agricultural activities pose a major threat to the world’s potable water supply. The persistent micro-pollutants …
Article scientifique
Atrazine: cytotoxicity, oxidative stress, apoptosis, testicular effects and chemopreventive Interventions
Atrazine (ATZ) is an environmental pollutant that interferes with several aspects of mammalian cellular processes including germ cell development, immunological, …
Article scientifique
Influence of different functionalized CdTe quantum dots on the accumulation of metals, developmental toxicity and respiration in different development stages of the zebrafish (Danio rerio)
Introduction: The bioaccumulation and differential effects of cadmium tellurium quantum dot (CdTe QDs) nanomaterials with different functional groups are poorly …
Article scientifique
First report on atrazine monitoring in drinking water from Ijebu-North, South-West Nigeria: Human health risk evaluation and reproductive toxicity studies
There are no available data on the level of atrazine in drinking water from rural agricultural areas in Nigeria and …
Article scientifique
Exposure Assessment of Silver and Gold Nanoparticles Generated During the Synthesis Process in a South African Research Laboratory
During the synthesis of engineered nanomaterials (ENMs), various occupational exposures occur, leading to health consequences. To date, there is paucity …
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