15 publication(s) trouvée(s)
Article scientifique
Adjunctive antimycobacterial and immunomodulatory effects of Allium cepa (pink variety) in a rabbit model of latent-like mycobacterial infection
Introduction Latent tuberculosis infection (LTBI) represents a major global reservoir for active disease, characterized by persistent, metabolically inactive bacilli that …
Article scientifique
Implementation of sequencing-based surveillance for drug-resistant tuberculosis in Nigeria
Sequencing for drug-resistant tuberculosis (DR-TB) surveillance was established in Nigeria for the first time, demonstrating a nationally coordinated referral network …
Article scientifique
Using interpretable decision trees to explore TB-HIV integration under data constraints: a proof-of-concept analysis
Background: Strengthening tuberculosis (TB) and HIV service integration remains a major priority in resource-limited settings, where fragmented care contributes to …
Article scientifique
Genomic characterization of drug-resistant Mycobacterium tuberculosis complex in western Kenya reveals predominance of isoniazid resistance and discordance with routine susceptibility testing
Introduction Whole-genome sequencing (WGS) data on resistance patterns in western Kenya remain limited. We evaluated resistant patterns of Mycobacterium tuberculosis …
Article scientifique
Acceptability and feasibility of oral swabs for tuberculosis diagnosis in young children: a qualitative study from Uganda and Peru
Background: Tuberculosis (TB) remains a leading cause of morbidity and mortality in young children, particularly in settings with limited diagnostic …
Article scientifique
Evaluation of a short, all oral treatment regimen including bedaquiline, delamanid, linezolid, clofazimine, and pyrazinamide named “Regimen C” for pre-XDR tuberculosis in Niger
Background The emergence of extensively drug-resistant tuberculosis (XDR-TB) poses a serious challenge to global tuberculosis control, particularly in high-burden countries …
Article scientifique
Predicting treatment adherence in patients with drug-resistant tuberculosis: insights from socioeconomic, demographic, and clinical factors of patients in the rural Eastern Cape
Background: Drug-resistant tuberculosis (DR-TB) poses a serious challenge to global health. Patients must follow complex medication regimens over long periods, …
Article scientifique
Optimizing use of data and evidence-related tools to complement routine surveillance systems for tuberculosis program planning
Background: Challenges and gaps with routine tuberculosis (TB) data and surveillance systems are well-known. To address them, numerous TB data …
Article scientifique
Risk factors associated with multidrug-resistant pulmonary tuberculosis in patients over 15 years old: a retrospective case-control study
Introduction Multidrug-Resistant Pulmonary Tuberculosis (MDR-TB) represents a serious public health problem, hindering disease control and increasing morbidity and mortality. This …
Article scientifique
Prevalence and risk factors of high blood pressure among persons assessed for TB at three health facilities in Lusaka, Zambia
Background: Low- and middle-income countries (LMICs) are experiencing a rapidly increasing burden of non-communicable diseases (NCDs), additionally straining health systems …
Article scientifique
Implications of serological, genomic, and epidemiological insights into Mycobacterium tuberculosis mixed infection in a human-managed African elephant (Loxodonta africana)
Zoonotic and reverse zoonotic tuberculosis pose a risk to human and animal health, especially when individuals are in close contact. …
Article scientifique
Analyses of blood-derived host biomarkers for pulmonary tuberculosis diagnosis in human immunodeficiency virus co-infected individuals in sub-Saharan Africa: a systematic review and meta-analysis
Objective: Our objective was to conduct a review of host blood-derived biomarkers as potential diagnostic targets for pulmonary TB and …
Article scientifique
Comorbidity profiles among sputum-positive tuberculosis patients in Cameroon
Introduction Comorbid non-communicable diseases (NCDs) like diabetes, cardiovascular diseases (CVD), kidney diseases, and hypertension, could have implications for tuberculosis (TB) …
Article scientifique
Innovative laboratory methods for improved tuberculosis diagnosis and drug-susceptibility testing
The laboratory plays a vital role in the diagnosis of all clinical forms of tuberculosis (TB), from microbiological confirmation of …
Article scientifique
Recognition and control of Mycobacterium tuberculosis-infected cells: from basics to the clinic: a NIAID/WGNV workshop report 2023
Vaccination is crucial for the control of tuberculosis (TB), and safe, more effective, and accessible vaccines against Mycobacterium tuberculosis (Mtb) …