12 publication(s) trouvée(s)
Article scientifique
A BAC-guided haplotype assembly pipeline increases the resolution of the virus resistance locus CMD2 in cassava
BACKGROUND: Cassava is an important crop for food security in the tropics where its production is jeopardized by several viral …
Article scientifique
The genetic and evolutionary basis of gene expression variation in East Africans
BACKGROUND: Mapping of quantitative trait loci (QTL) associated with molecular phenotypes is a powerful approach for identifying the genes and …
Article scientifique
Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa
BACKGROUND: Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite …
Article scientifique
The recombination landscape of the Khoe-San likely represents the upper limits of recombination divergence in humans
BACKGROUND: Recombination maps are important resources for epidemiological and evolutionary analyses; however, there are currently no recombination maps representing any …
Article scientifique
A theory-based practical solution to correct for sex-differential participation bias
Most genomic cohorts are retrospective where the exposures and outcomes are predetermined prior to sample collection. Therefore, a spurious association …
Article scientifique
1200 high-quality metagenome-assembled genomes from the rumen of African cattle and their relevance in the context of sub-optimal feeding
BACKGROUND: The Boran (Bos indicus), indigenous Zebu cattle breed from sub-Saharan Africa, is remarkably well adapted to harsh tropical environments. …
Article scientifique
Correction to: African evolutionary history inferred from whole genome sequence data of 44 indigenous African populations
Following publication of the original article [1], a typographical error in the formula for calculating di in the “Scans for …
Article scientifique
Correction to: Identification of novel Y chromosome encoded transcripts by testis transcriptome analysis of mice with deletions of the Y chromosome long arm
Following publication of the original article [1], the following error was reported: The actin control panel in Fig. 3 of …
Article scientifique
The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy
BACKGROUND: Combination therapy is one of the most effective tools for limiting the emergence of drug resistance in pathogens. Despite …
Article scientifique
The genome landscape of indigenous African cattle
BACKGROUND: The history of African indigenous cattle and their adaptation to environmental and human selection pressure is at the root …
Article scientifique
Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus
BACKGROUND: In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains …
Article scientifique
Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects
BACKGROUND: The CRISPR-Cas9 system is a widely utilized platform for transgenic animal production in various species, although its off-target effects …