11 publication(s) trouvée(s)
Article scientifique
Longitudinal analysis within one hospital in sub-Saharan Africa over 20 years reveals repeated replacements of dominant clones of Klebsiella pneumoniae and stresses the importance to include temporal patterns for vaccine design considerations
BACKGROUND: Infections caused by multidrug-resistant gram-negative bacteria present a severe threat to global public health. The WHO defines drug-resistant Klebsiella …
Article scientifique
Untargeted metabolomic profiling reveals molecular signatures associated with type 2 diabetes in Nigerians
BACKGROUND: Type 2 diabetes (T2D) has reached epidemic proportions globally, including in Africa. However, molecular studies to understand the pathophysiology …
Article scientifique
Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans
BACKGROUND: African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of stroke in these populations …
Article scientifique
Building blocks for better biorepositories in Africa
BACKGROUND: Biorepositories archive and distribute well-characterized biospecimens for research to support the development of medical diagnostics and therapeutics. Knowledge of …
Article scientifique
Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions
Early identification of genetic risk factors for complex diseases can enable timely interventions and prevent serious outcomes, including mortality. While …
Article scientifique
Genome-wide interrogation of structural variation reveals novel African-specific prostate cancer oncogenic drivers
BACKGROUND: African ancestry is a significant risk factor for advanced prostate cancer (PCa). Mortality rates in sub-Saharan Africa are 2.5-fold …
Article scientifique
Rapid molecular diagnostics of tuberculosis resistance by targeted stool sequencing
BACKGROUND: Stool is an important diagnostic specimen for tuberculosis in populations who struggle to provide sputum, such as children or …
Article scientifique
MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era
BACKGROUND: Multidrug-resistant (MDR) Mycobacterium tuberculosis complex strains not detected by commercial molecular drug susceptibility testing (mDST) assays due to the …
Article scientifique
Bugs, drugs, and HIV: the role of the vaginal microbiome in HIV risk and antiretroviral efficacy for HIV prevention
Advances in molecular tools to characterize the microbiome have led to the discovery of unique roles for microbes in human …
Article scientifique
New var reconstruction algorithm exposes high var sequence diversity in a single geographic location in Mali
BACKGROUND: Encoded by the var gene family, highly variable Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) proteins mediate tissue-specific cytoadherence of …
Article scientifique
Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal
BACKGROUND: As public health interventions drive parasite populations to elimination, genetic epidemiology models that incorporate population genomics can be powerful …