221 publication(s) trouvée(s)
Article scientifique
Cross-reaction between mouse and rat immunoglobulin G: does it matter in sandwich ELISA?
BACKGROUND: Sandwich ELISA is an ideal antigen detection and quantification assay. Recently, it was used as the basic concept for …
Article scientifique
Narrative role of vitamin D receptor with osteoporosis and obesity in a sample of Egyptian females: a pilot study
BACKGROUND: Vitamin D receptor (VDR) is known as one of the cellular regulators for several metabolic pathways indicating its pivotal …
Article scientifique
Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients
BACKGROUND: Variants in the signal transducer and activator of transcription 4 (STAT4) gene have an important role in the incident …
Article scientifique
Quaternary diagnostics scheme for mucolipidosis II and detection of novel mutation in GNPTAB gene
BACKGROUND: Mucolipidosis II (ML II α/β) is an inherited lysosomal storage disorder caused by deficiency of GlcNAc-phosphotransferase enzyme and results …
Article scientifique
SARS-CoV-2 host cell entry: an in silico investigation of potential inhibitory roles of terpenoids
BACKGROUND: Targeting viral cell entry proteins is an emerging therapeutic strategy for inhibiting the first stage of SARS-CoV-2 infection. In …
Article scientifique
Characterization of β-glucosidase of Lactobacillus plantarum FSO1 and Candida pelliculosa L18 isolated from traditional fermented green olive
BACKGROUND: Oleuropein, the main bitter phenolic glucoside responsible for green olive bitterness, may be degraded by the β-glucosidase enzyme to …
Article scientifique
Molecular phylogeny and pathogenicity of indigenous Beauveria bassiana against the tomato leafminer, Tuta absoluta Meyrick 1917 (Lepidoptera: Gelechiidae), in Ethiopia
Tuta absoluta Meyrick 1917 (Lepidoptera: Gelechiidae) is an invasive, pesticide resistant, and a major treat of tomato production in the …
Article scientifique
Molecular identification and in vitro evaluation of probiotic functional properties of some Egyptian lactic acid bacteria and yeasts
BACKGROUND: The health-promoting effects along with global economic importance of consuming food products supplemented with probiotic microorganisms encouraged the researchers …
Article scientifique
GABAA receptors: structure, function, pharmacology, and related disorders
γ-Aminobutyric acid sub-type A receptors (GABA A Rs) are the most prominent inhibitory neurotransmitter receptors in the CNS. They are …
Article scientifique
IGF1R, IGFALS, and IGFBP3 gene copy number variations in a group of non-syndromic Egyptian short children
BACKGROUND: Insulin-like growth factor-1 (IGF-1) is required for normal intrauterine and postnatal growth, and this action is mediated through IGF1 …
Article scientifique
Metabolic profiling, in vitro propagation, and genetic assessment of the endangered rare plant Anarrhinum pubescens
BACKGROUND: Anarrhinum pubescens Fresen. (Plantaginaceae) is a rare plant, endemic to the Saint Catherine area, of South Sinai, Egypt. Earlier …
Article scientifique
Molecular identification and antimicrobial activities of some wild Egyptian mushrooms: Bjerkandera adusta as a promising source of bioactive antimicrobial phenolic compounds
BACKGROUND: The discovery of potential, new cost-effective drug resources in the form of bioactive compounds from mushrooms is one way …
Article scientifique
Screening and characterization of hypothetical proteins of Plasmodium falciparum as novel vaccine candidates in the fight against malaria using reverse vaccinology
BACKGROUND: Plasmodium falciparum is the most deadly and leading cause of morbidity and mortality in Africa. About 90% of all …
Article scientifique
Isolation and characterization of marine sponge–associated Streptomyces sp. NMF6 strain producing secondary metabolite(s) possessing antimicrobial, antioxidant, anticancer, and antiviral activities
BACKGROUND: Actinomycetes associated with marine sponge represent a promising source of bioactive compounds. Herein, we report the isolation, identification, and …
Article scientifique
Immunofluorescence studies to dissect the impact of Cockayne syndrome A alterations on the protein interaction and cellular localization
Cockayne syndrome (CS), which was discovered by Alfred Cockayne nearly 75 years ago, is a rare autosomal recessive disorder characterized …
Article scientifique
Evaluation of MLPA as a comprehensive molecular cytogenetic tool to detect cytogenetic markers of chronic lymphocytic leukemia in Egyptian patients
BACKGROUND: Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia. This disease is genetically heterogeneous, and approximately …
Article scientifique
Implications of targeted next-generation sequencing for bladder cancer: report of four cases
BACKGROUND: Bladder cancer is considered heterogeneous diseases with two major subgroups: non-muscle- invasive bladder cancer (NMIBC) and muscle invasive bladder …
Article scientifique
In silico analysis of promoter region and regulatory elements of mitogenome co-expressed trn gene clusters encoding for bio-pesticide in entomopathogenic fungus, Metarhizium anisopliae: strain ME1
BACKGROUND: Pest control strategies almost entirely rely on chemical insecticides, which cause environmental problems such as biosphere deterioration and emergence …
Article scientifique
Scaling-up production of cost-effective and eco-friendly bio-fertilizer and its application on Barley green fodder via IoT hydroponic system
BACKGROUND: Plant-associated microbes (endophytes) have a significant relationship to enhance plant growth and crop productivity by producing proficient bioactive metabolites. …
Article scientifique
PPAR agonists as effective adjuvants for COVID-19 vaccines, by modifying immunogenetics: a review of literature
BACKGROUND: Several coronavirus vaccine have been fast-tracked to halt the pandemic, the usage of immune adjuvants that can boost immunological …