5 publication(s) trouvée(s)
Article scientifique
Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry
Rapid adaptation to novel environments is crucial for survival, and this ability is impaired in many neuropsychiatric disorders. Understanding neural …
Article scientifique
Nicotinamide attenuates the decrease in dendritic spine density in hippocampal primary neurons from 5xFAD mice, an Alzheimer’s disease animal model
Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by memory loss and the presence of amyloid plaques and …
Article scientifique
Enhancement of dendritic persistent Na+ currents by mGluR5 leads to an advancement of spike timing with an increase in temporal precision
Timing and temporal precision of action potential generation are thought to be important for encoding of information in the brain. …
Article scientifique
Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models
Alzheimer's disease (AD) is characterized by neurotoxicity mediated by the accumulation of beta amyloid (Aβ) oligomers, causing neuronal loss and …
Article scientifique
Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition
Alzheimer’s disease (AD) is a neurodegenerative disorder associated with deficits in cognition and synaptic plasticity. While accumulation of amyloid β …