397 publication(s) trouvée(s)
Article scientifique
Investigating the etiologies of non-malarial febrile illness in Senegal using metagenomic sequencing
The worldwide decline in malaria incidence is revealing the extensive burden of non-malarial febrile illness (NMFI), which remains poorly understood …
Article scientifique
African bushpigs exhibit porous species boundaries and appeared in Madagascar concurrently with human arrival
Abstract Several African mammals exhibit a phylogeographic pattern where closely related taxa are split between West/Central and East/Southern Africa, but …
Article scientifique
Incidence and transmission of respiratory syncytial virus in urban and rural South Africa, 2017-2018
Data on respiratory syncytial virus (RSV) incidence and household transmission are limited. To describe RSV incidence and transmission, we conducted …
Article scientifique
Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa
Abstract In high-income countries, mosaic chromosomal alterations in peripheral blood leukocytes are associated with an elevated risk of adverse health …
Article scientifique
Whole genomes from Angola and Mozambique inform about the origins and dispersals of major African migrations
As the continent of origin for our species, Africa harbours the highest levels of diversity anywhere on Earth. However, many …
Article scientifique
Accelerating African neuroscience to provide an equitable framework using perspectives from West and Southern Africa
Drawing on perspectives from West and Southern Africa, this Comment critically examines the current state of neuroscience progress in Africa, …
Article scientifique
Prostate cancer genetic risk and associated aggressive disease in men of African ancestry
African ancestry is a significant risk factor for prostate cancer and advanced disease. Yet, genetic studies have largely been conducted …
Article scientifique
Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study
Most hypertension-related genome-wide association studies (GWASs) focus on non-African populations, despite hypertension (a major risk factor for cardiovascular disease) being …
Article scientifique
Quantum transport of high-dimensional spatial information with a nonlinear detector
Information exchange between two distant parties, where information is shared without physically transporting it, is a crucial resource in future …
Article scientifique
Evolution and neutralization escape of the SARS-CoV-2 BA.2.86 subvariant
Omicron BA.2.86 subvariant differs from Omicron BA.2 as well as recently circulating variants by over 30 mutations in the spike …
Article scientifique
The genomic epidemiology of shigellosis in South Africa
Shigellosis, a leading cause of diarrhoeal mortality and morbidity globally, predominantly affects children under five years of age living in …
Article scientifique
Cytolytic circumsporozoite-specific memory CD4+ T cell clones are expanded during Plasmodium falciparum infection
Abstract Clinical immunity against Plasmodium falciparum infection develops in residents of malaria endemic regions, manifesting in reduced clinical symptoms during …
Article scientifique
A smooth tubercle bacillus from Ethiopia phylogenetically close to the Mycobacterium tuberculosis complex
The Mycobacterium tuberculosis complex (MTBC) includes several human- and animal-adapted pathogens. It is thought to have originated in East Africa …
Article scientifique
The metabolic, virulence and antimicrobial resistance profiles of colonising Streptococcus pneumoniae shift after PCV13 introduction in urban Malawi
Streptococcus pneumoniae causes substantial mortality among children under 5-years-old worldwide. Polysaccharide conjugate vaccines (PCVs) are highly effective at reducing vaccine …
Article scientifique
Fetal biometry and amniotic fluid volume assessment end-to-end automation using Deep Learning
Fetal biometry and amniotic fluid volume assessments are two essential yet repetitive tasks in fetal ultrasound screening scans, aiding in …
Article scientifique
Adaptive traits of cysts of the snow alga Sanguina nivaloides unveiled by 3D subcellular imaging
Abstract Sanguina nivaloides is the main alga forming red snowfields in high mountains and Polar Regions. It is non-cultivable. Analysis …
Article scientifique
Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems
The COVID-19 pandemic has profoundly impacted health systems globally and robust surveillance has been critical for pandemic control, however not …
Article scientifique
Malaria surveillance reveals parasite relatedness, signatures of selection, and correlates of transmission across Senegal
We here analyze data from the first year of an ongoing nationwide program of genetic surveillance of Plasmodium falciparum parasites …
Article scientifique
Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study
The mortality impact of COVID-19 in Africa remains controversial because most countries lack vital registration. We analysed excess mortality in …
Article scientifique
Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum
Plasmodium falciparum secretes extracellular vesicles (PfEVs) that contain parasite-derived RNA. However, the significance of the secreted RNA remains unexplored. Here, …