43 publication(s) trouvée(s)
Article scientifique
Reconstruction of historical malaria transmission in Senegal using multiplex serocatalytic models
Abstract The advent of multiplexing technologies, allowing antibodies to hundreds of antigens to be measured in a single test, has …
Article scientifique
Sub-national modelling of surveillance sensitivity to inform declaration of disease elimination: A retrospective validation against the elimination of wild poliovirus in Nigeria
A fundamental question in the global commitment to polio eradication is how long a period of absence would be consistent …
Article scientifique
An age-structured spatially varying coefficient model for high-resolution mapping of vaccination coverage
High-resolution maps of vaccination coverage are valuable for uncovering heterogeneities in coverage to inform vaccine delivery strategies. Coverage maps stratified …
Article scientifique
Non-coding RNA 7SK drives tumor resistance by coupling local oncogenic activation with global transcriptional repression
The conserved non-coding RNA 7SK is a well-established global transcriptional repressor, yet its context-specific functions in cancer and therapy resistance …
Article scientifique
Modelling the relative contribution of infection, routine vaccination and supplementary immunisation activities to measles seroconversion in Kenyan Children
BACKGROUND: Measles outbreaks continue to cause a large burden of disease in Africa including Kenya. We used information from regular …
Article scientifique
serojump: A Bayesian tool for inferring infection timing and antibody kinetics from longitudinal serological data
Understanding acute infectious disease dynamics at individual and population levels is critical for informing public health preparedness and response. Serological …
Article scientifique
Population-level toggling of T cell immune escape at human leukocyte antigen anchor residues in SARS-CoV-2 Spike proteins, in an ethnically diverse population region
There is currently limited understanding of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) adaptation to the human leukocyte antigen (HLA) …
Article scientifique
Uncovering the impact of randomness in HIV hotspot formation: A mathematical modeling study
BACKGROUND: HIV hotspots, regions with higher prevalence than surrounding areas, are observed across Africa, yet their formation and persistence mechanisms …
Article scientifique
Fitting dynamic measles models to subnational case notification data from Ethiopia: Methodological challenges and key considerations
In many settings, ongoing measles transmission is maintained due to pockets of un- or under-vaccinated individuals even if the critical …
Article scientifique
Simulation-based validation of a method to detect changes in SARS-CoV-2 reinfection risk
Given the high global seroprevalence of SARS-CoV-2, understanding the risk of reinfection has become increasingly important. Models developed to track …
Article scientifique
Insights to HIV-1 coreceptor usage by estimating HLA adaptation with Bayesian generalized linear mixed models
The mechanisms triggering the human immunodeficiency virus type I (HIV-1) to switch the coreceptor usage from CCR5 to CXCR4 during …
Article scientifique
A simulation-based method to inform serosurvey design for estimating the force of infection using existing blood samples
The extent to which dengue virus has been circulating globally and especially in Africa is largely unknown. Testing available blood …
Article scientifique
Modelling African horse sickness emergence and transmission in the South African control area using a deterministic metapopulation approach
African horse sickness is an equine orbivirus transmitted by Culicoides Latreille biting midges. In the last 80 years, it has …
Article scientifique
Deep learning approaches to landmark detection in tsetse wing images
Morphometric analysis of wings has been suggested for identifying and controlling isolated populations of tsetse (Glossina spp), vectors of human …
Article scientifique
A mentorship and incubation program using project-based learning to build a professional bioinformatics pipeline in Kenya
The demand for well-trained bioinformaticians to support genomics research continues to rise. Unfortunately, undergraduate training in Kenya does not prepare …
Article scientifique
Infrastructure for bioinformatics applications in Tanzania: Lessons from the Sickle Cell Programme
Sickle cell disease (SCD) is a common genetic disorder in Africa. Some ongoing work in SCD research includes the analysis …
Article scientifique
Spatiotemporal spread of Plasmodium falciparum mutations for resistance to sulfadoxine-pyrimethamine across Africa, 1990–2020
BACKGROUND: Sulfadoxine-pyrimethamine (SP) is recommended in Africa in several antimalarial preventive regimens including Intermittent Preventive Treatment in pregnant women (IPTp), …
Article scientifique
Ten simple rules for developing bioinformatics capacity at an academic institution
Bioinformatics is an applied interdisciplinary field whose primary purpose is to develop and deploy computational techniques to store, organize, and …
Article scientifique
Estimating the contribution of HIV-infected adults to household pneumococcal transmission in South Africa, 2016–2018: A hidden Markov modelling study
Human immunodeficiency virus (HIV) infected adults are at a higher risk of pneumococcal colonisation and disease, even while receiving antiretroviral …
Article scientifique
Bioinformatics in Sudan: Status and challenges case study: The National University-Sudan
The ever increasing applications of bioinformatics in providing effective interpretation of large and complex biological data require expertise in the …
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