22 publication(s) trouvée(s)
Article scientifique
Recurrent evolution of cryptic triploids in cultivated enset increases yield
Abstract The high incidence of polyploidy in crops could be explained if domestication involved the selection of polyploids (cytotypes with …
Article scientifique
Polygenic risk scores and Parkinson’s disease in South Africa advancing ancestry informed disease prediction
Parkinson's disease (PD) is a complex neurodegenerative disorder with environmental and genetic influences. Using genotyping array data of 661 South …
Article scientifique
Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments
The apolipoprotein ε4 (APOE ε4) isoform directly alters cholesterol and immune biology and is associated with an increased risk of …
Article scientifique
Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria
Blood group O is associated with protection against severe malaria and reduced size and stability of P. falciparum-host red blood …
Article scientifique
Neutrophil extracellular trap formation and gene programs distinguish TST/IGRA sensitization outcomes among Mycobacterium tuberculosis exposed persons living with HIV
Persons living with HIV (PLWH) have an increased risk for tuberculosis (TB). After prolonged and repeated exposure, some PLWH never …
Article scientifique
Tuberculosis severity associates with variants and eQTLs related to vascular biology and infection-induced inflammation
BACKGROUND: Tuberculosis (TB) remains a major public health problem globally, even compared to COVID-19. Genome-wide studies have failed to discover …
Article scientifique
The duplicated P450s CYP6P9a/b drive carbamates and pyrethroids cross-resistance in the major African malaria vector Anopheles funestus
Cross-resistance to insecticides in multiple resistant malaria vectors is hampering resistance management. Understanding its underlying molecular basis is critical to …
Article scientifique
Multi-insecticide resistant malaria vectors in the field remain susceptible to malathion, despite the presence of Ace1 point mutations
Insecticide resistance in Anopheles mosquitoes is seriously threatening the success of insecticide-based malaria vector control. Surveillance of insecticide resistance in …
Article scientifique
Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria
Individuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. Immunity to disease is thought to reflect the acquisition …
Article scientifique
Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populations
The natural history of tuberculosis (TB) is characterized by a large inter-individual outcome variability after exposure to Mycobacterium tuberculosis. Specifically, …
Article scientifique
Immune fingerprinting through repertoire similarity
Immune repertoires provide a unique fingerprint reflecting the immune history of individuals, with potential applications in precision medicine. However, the …
Article scientifique
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus
Vector population control using insecticides is a key element of current strategies to prevent malaria transmission in Africa. The introduction …
Article scientifique
A frog with three sex chromosomes that co-mingle together in nature: Xenopus tropicalis has a degenerate W and a Y that evolved from a Z chromosome
In many species, sexual differentiation is a vital prelude to reproduction, and disruption of this process can have severe fitness …
Article scientifique
Exome-wide association study reveals largely distinct gene sets underlying specific resistance to dengue virus types 1 and 3 in Aedes aegypti
Although specific interactions between host and pathogen genotypes have been well documented in invertebrates, the identification of host genes involved …
Article scientifique
Interaction between host genes and Mycobacterium tuberculosis lineage can affect tuberculosis severity: Evidence for coevolution?
Genetic studies of both the human host and Mycobacterium tuberculosis (MTB) demonstrate independent association with tuberculosis (TB) risk. However, neither …
Article scientifique
Distinct domains of Escherichia coli IgaA connect envelope stress sensing and down-regulation of the Rcs phosphorelay across subcellular compartments
In enterobacteria, the Rcs system (Regulator of capsule synthesis) monitors envelope integrity and induces a stress response when damages occur …
Article scientifique
Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania
Significant selection pressure has been exerted on the genomes of human populations exposed to Plasmodium falciparum infection, resulting in the …
Article scientifique
A chromosome 5q31.1 locus associates with tuberculin skin test reactivity in HIV-positive individuals from tuberculosis hyper-endemic regions in east Africa
One in three people has been infected with Mycobacterium tuberculosis (MTB), and the risk for MTB infection in HIV-infected individuals …
Article scientifique
Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations
Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden …
Article scientifique
Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies
Schinzel-Giedion syndrome (SGS) is a rare developmental disorder characterized by multiple malformations, severe neurological alterations and increased risk of malignancy. …
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