61 publication(s) trouvée(s)
Article scientifique
Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania
In settings with high tuberculosis (TB) endemicity, distinct genotypes of the Mycobacterium tuberculosis complex (MTBC) often differ in prevalence. However, …
Article scientifique
Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies
Broadly neutralizing antibodies (bNAbs) that target the membrane-proximal external region (MPER) of HIV gp41 envelope, such as 4E10, VRC42.01 and …
Article scientifique
Tuberculosis caused by Mycobacterium africanum: Knowns and unknowns
Tuberculosis (TB), one of the deadliest threats to human health, is mainly caused by 2 highly related and human-adapted bacteria …
Article scientifique
ADCC-mediating non-neutralizing antibodies can exert immune pressure in early HIV-1 infection
Despite antibody-dependent cellular cytotoxicity (ADCC) responses being implicated in protection from HIV-1 infection, there is limited evidence that they control …
Article scientifique
An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults
Natural Killer (NK) cells contribute to HIV control in adults, but HLA-B-mediated T-cell activity has a more substantial impact on …
Article scientifique
Differential pathogenesis of closely related 2018 Nigerian outbreak clade III Lassa virus isolates
Nigeria continues to experience ever increasing annual outbreaks of Lassa fever (LF). The World Health Organization has recently declared Lassa …
Article scientifique
Tackling protozoan parasites of cattle in sub-Saharan Africa
Cattle are an incredibly valuable asset to farmers throughout the world (Fig 1). They provide power, transport, fertiliser, fuel, and …
Article scientifique
T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy
HIV cerebrospinal fluid (CSF) escape, where HIV is suppressed in blood but detectable in CSF, occurs when HIV persists in …
Article scientifique
Emodepside targets SLO-1 channels of Onchocerca ochengi and induces broad anthelmintic effects in a bovine model of onchocerciasis
Onchocerciasis (river blindness), caused by the filarial worm Onchocerca volvulus, is a neglected tropical disease mostly affecting sub-Saharan Africa and …
Article scientifique
Incidence, household transmission, and neutralizing antibody seroprevalence of Coronavirus Disease 2019 in Egypt: Results of a community-based cohort
SARS-CoV-2 virus is transmitted in closed settings to people in contact with COVID-19 patients such as healthcare workers and household …
Article scientifique
Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis patient bioaerosols
Interrupting transmission is an attractive anti-tuberculosis (TB) strategy but it remains underexplored owing to our poor understanding of the events …
Article scientifique
Symmetrical arrangement of positively charged residues around the 5-fold axes of SAT type foot-and-mouth disease virus enhances cell culture of field viruses
Field isolates of foot-and-mouth disease viruses (FMDVs) utilize integrin-mediated cell entry but many, including Southern African Territories (SAT) viruses, are …
Article scientifique
Post-tuberculosis chronic pulmonary aspergillosis: An emerging public health concern
CPA is a progressive respiratory syndrome that largely occur in immunocompetent or subtly immunocompromised individuals with underlying structural lung diseases, …
Article scientifique
Comparative transcriptome analysis of endemic and epidemic Kaposi’s sarcoma (KS) lesions and the secondary role of HIV-1 in KS pathogenesis
In sub-Saharan Africa, endemic Kaposi's sarcoma (EnKS) is still prevalent despite high incidence of epidemic Kaposi's sarcoma (EpKS) resulting from …
Article scientifique
Exploring potential of vaginal Lactobacillus isolates from South African women for enhancing treatment for bacterial vaginosis
Antibiotics continue to be the standard-of-care for bacterial vaginosis (BV), although recurrence rates are high. Vaginal probiotics may improve durability …
Article scientifique
High crossreactivity of human T cell responses between Lassa virus lineages
Lassa virus infects hundreds of thousands of people each year across rural West Africa, resulting in a high number of …
Article scientifique
Molecular dating and viral load growth rates suggested that the eclipse phase lasted about a week in HIV-1 infected adults in East Africa and Thailand
Most HIV-1 infected individuals do not know their infection dates. Precise infection timing is crucial information for studies that document …
Article scientifique
The alternative cap-binding complex is required for antiviral defense in vivo
Cellular response to environmental challenges requires immediate and precise regulation of transcriptional programs. During viral infections, this includes the expression …
Article scientifique
Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion
Prion or PrPSc is the proteinaceous infectious agent causing prion diseases in various mammalian species. Despite decades of research, the …
Article scientifique
Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa
Since the ignition of the HIV-1 group M pandemic in the beginning of the 20th century, group M lineages have …