18 publication(s) trouvée(s)
Article scientifique
Childhood necrotising pneumonia, empyema and complicated parapneumonic effusion secondary to community acquired pneumonia: report of 158 cases from a tertiary hospital in Egypt
BACKGROUND: Incidence of childhood complicated community acquired pneumonia (cCAP) is increasing worldwide. Necrotising pneumonia (NP), empyema and complicated parapneumonic effusion …
Article scientifique
Causes and MEchanisms foR non-atopic Asthma in Children (CAMERA) study: rationale and protocol
BACKGROUND: The Causes And MEchanisms foR non-atopic Asthma in children (CAMERA) study was designed to investigate risk factors and mechanisms …
Article scientifique
Pleural fluid agitation for improving the microbiologic diagnostic yield in pleural infection: a feasibility study
BACKGROUND: Pleural infection is a commonly encountered respiratory disease but in > 40% the underlying microbiologic etiology is unknown. This …
Article scientifique
Atorvastatin for reduction of 28-day mortality in severe and critical COVID-19 patients: a randomized controlled trial
BACKGROUND: COVID-19 is an abnormal host response to the SARS-CoV-2 infection, which is associated with endothelial dysfunction and multi-organ failure. …
Article scientifique
Challenges in the diagnosis of asthma in children, what are the solutions? A scoping review of 3 countries in sub Saharan Africa
BACKGROUND: Asthma is the commonest chronic respiratory tract disease in children. In low-income countries, challenges exist in asthma diagnosis. In …
Article scientifique
The effects of anti-inflammatory agents as host-directed adjunct treatment of tuberculosis in humans: a systematic review and meta-analysis
BACKGROUND: The potential role of adjunctive anti-inflammatory therapy to enhance tuberculosis (TB) treatment has recently received increasing interest. There is, …
Article scientifique
In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression
BACKGROUND: The pathogenesis of pulmonary arterial hypertension (PAH) involves many signalling pathways. MicroRNAs are potential candidates involved in simultaneously coordinating …
Article scientifique
Effect of average volume-assured pressure support treatment on health-related quality of life in COPD patients with chronic hypercapnic respiratory failure: a randomized trial
The long-term effect of average volume-assured pressure support (AVAPS) on health-related quality of life (HRQOL) in chronic obstructive pulmonary disease …
Article scientifique
The socioeconomic burden of chronic lung disease in low-resource settings across the globe – an observational FRESH AIR study
BACKGROUND: Low-resource settings are disproportionally burdened by chronic lung disease due to early childhood disadvantages and indoor/outdoor air pollution. However, …
Article scientifique
High level of fluorescent oxidation products and worsening of asthma control over time
High Fluorescent oxidation products level (FlOPs), a global oxidative stress biomarker, was associated cross-sectionally with poor asthma outcomes but its …
Article scientifique
Ambient air pollution and respiratory mortality in Xi’an, China: a time-series analysis
Although air pollution is a known fundamental problem in China, few studies have investigated the associations between ambient air pollution …
Article scientifique
Gasometric gradients between blood obtained from the pulmonary artery wedge and pulmonary artery positions in pulmonary arterial hypertension
INTRODUCTION: Little is known on the pulmonary gradients of oxyhemoglobin, carboxyhemoglobin and methemoglobin in pulmonary arterial hypertension (PAH). We sought …
Article scientifique
Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock
BACKGROUND: Sepsis is a multi-system syndrome that remains the leading cause of mortality and critical illness worldwide, with hemodynamic support …
Article scientifique
The impact of HIV on the prevalence of asthma in Uganda: a general population survey
BACKGROUND: HIV and asthma are highly prevalent diseases in Africa but few studies have assessed the impact of HIV on …
Article scientifique
Anti-bacterial antibody and T cell responses in bronchiectasis are differentially associated with lung colonization and disease
As a way to determine markers of infection or disease informing disease management, and to reveal disease-associated immune mechanisms, this …
Article scientifique
Human alveolar macrophages predominately express combined classical M1 and M2 surface markers in steady state
Alveolar macrophages (AM) are critical to the homeostasis of the inflammatory environment in the lung. Differential expression of surface markers …
Article scientifique
Structure and functional impact of seed region variant in MIR-499 gene family in bronchial asthma
Small non-coding RNAs (microRNAs) have been evolved to master numerous cellular processes. Genetic variants within microRNA seed region might influence …
Article scientifique
Association of stem cell factor gene expression with severity and atopic state in patients with bronchial asthma
BACKGROUND: Bronchial asthma is a chronic inflammatory and remodeling disorder of the airways, in which many cells, cellular elements, and …