20 publication(s) trouvée(s)
Article scientifique
The KT Jeang retrovirology prize 2023: Thumbi Ndung’u
Thumbi Ndung’u grew up on a coffee farm in rural Kenya, where he received his primary and high school education …
Article scientifique
Reduced CCR5 expression among Uganda HIV controllers
BACKGROUND: Several mechanisms including reduced CCR5 expression, protective HLA, viral restriction factors, broadly neutralizing antibodies, and more efficient T-cell responses, …
Article scientifique
HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity
BACKGROUND: Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The role of Nef-mediated down-regulation of the host restriction factor …
Article scientifique
A large population sample of African HIV genomes from the 1980s reveals a reduction in subtype D over time associated with propensity for CXCR4 tropism
We present 109 near full-length HIV genomes amplified from blood serum samples obtained during early 1986 from across Uganda, which …
Article scientifique
Bone marrow stromal antigen 2 (BST-2) genetic variants influence expression levels and disease outcome in HIV-1 chronically infected patients
Abstract Background Bone marrow stromal antigen 2 (BST-2) also known as Tetherin (CD317/HM1.24), is a host restriction factor that blocks …
Article scientifique
Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda
Abstract Background Our understanding of the peripheral human immunodeficiency virus type 1 (HIV-1) reservoir is strongly biased towards subtype B …
Article scientifique
Addressing an HIV cure in LMIC
HIV-1 persists in infected individuals despite years of antiretroviral therapy (ART), due to the formation of a stable and long-lived …
Article scientifique
Subtype-specific differences in Gag-protease replication capacity of HIV-1 isolates from East and West Africa
BACKGROUND: The HIV-1 epidemic in sub-Saharan Africa is heterogeneous with diverse unevenly distributed subtypes and regional differences in prevalence. Subtype-specific …
Article scientifique
Increased HIV-1 pretreatment drug resistance with consistent clade homogeneity among ART-naive HIV-1 infected individuals in Ethiopia
BACKGROUND: The development of pretreatment drug resistance (PDR) is becoming an obstacle to the success of antiretroviral therapy (ART). Besides, …
Article scientifique
Variations in Trim5α and Cyclophilin A genes among HIV-1 elite controllers and non controllers in Uganda: a laboratory-based cross-sectional study
BACKGROUND: Tripartite Motif Containing 5 alpha (TRIM5α), a restriction factor produced ubiquitously in cells and tissues of the body plays …
Article scientifique
Comparison of pathological clotting using haematological, functional and morphological investigations in HIV-positive and HIV-negative patients with deep vein thrombosis
BACKGROUND: Patients infected with the human immunodeficiency virus (HIV) are more prone to systemic inflammation and pathological clotting, and many …
Article scientifique
Cardiovascular disease risk in an urban African population: a cross-sectional analysis on the role of HIV and antiretroviral treatment
BACKGROUND: Life expectancy is increasing in the HIV-positive population and age-related non-communicable diseases, such as cardiovascular disease, (CVD) are seen …
Article scientifique
Engineering and characterising a novel, highly potent bispecific antibody iMab-CAP256 that targets HIV-1
The existing repertoire of HIV-1 patient derived broadly neutralising antibodies (bNAbs) that target the HIV-1 envelope glycoprotein (Env) present numerous …
Article scientifique
A trip down memory lane with Retrovirology
Fifteen years ago, Retrovirology was amongst the first open-access journals to be established through Biomed Central, instigated by our late …
Article scientifique
Lipid levels, insulin resistance and cardiovascular risk over 96 weeks of antiretroviral therapy: a randomised controlled trial comparing low-dose stavudine and tenofovir
BACKGROUND: HIV infection and antiretroviral treatment are associated with changes in lipid levels, insulin resistance and risk of cardiovascular disease …
Article scientifique
Pre-exposure prophylaxis (PrEP) in an era of stalled HIV prevention: Can it change the game?
Pre-exposure prophylaxis (PrEP) for HIV prevention has evolved significantly over the years where clinical trials have now demonstrated the efficacy …
Article scientifique
The HIV-1 transmission bottleneck
It is well established that most new systemic infections of HIV-1 can be traced back to one or a limited …
Article scientifique
Evidence against a role for jaagsiekte sheep retrovirus in human lung cancer
BACKGROUND: Jaagsiekte sheep retrovirus (JSRV) causes a contagious lung cancer in sheep and goats that can be transmitted by aerosols …
Article scientifique
Breast milk and in utero transmission of HIV-1 select for envelope variants with unique molecular signatures
BACKGROUND: Mother-to-child transmission of human immunodeficiency virus-type 1 (HIV-1) poses a serious health threat in developing countries, and adequate interventions …
Article scientifique
Multiple HIV-1/M + HIV-1/O dual infections and new HIV-1/MO inter-group recombinant forms detected in Cameroon
BACKGROUND: Due to the prevalence of HIV-1 group M and the endemicity of HIV-1 group O infections in Cameroon, patients …